1. Immunology/Inflammation
  2. Aryl Hydrocarbon Receptor

Aryl Hydrocarbon Receptor

Aryl Hydrocarbon Receptor (AhR or AHR or ahr or ahR) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic (aryl) hydrocarbons, and regulates xenobiotic-metabolizing enzymes such as cytochrome P450s, most notably cyp 1A1.

Aryl Hydrocarbon Receptor is a member of the family of basic helix-loop-helix transcription factors. AhR binds several exogenous ligands including natural plant flavonoids, polyphenolics and indoles, as well as synthetic polycyclic aromatic hydrocarbons and dioxin-like compounds. AhR is a cytosolic transcription factor that is normally inactive, binding to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription.

Aryl Hydrocarbon Receptor Related Products (12):

Cat. No. Product Name Effect Purity
  • HY-15484
    Pifithrin-α hydrobromide Agonist 98.28%
    Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis.
  • HY-15001
    StemRegenin 1 Antagonist 99.50%
    StemRegenin 1 是一种有效的芳香烃受体 (AhR) 拮抗剂,IC50 为 127 nM。
  • HY-12451
    FICZ Agonist 98.19%
    FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM.
  • HY-19317
    ITE Agonist >98.0%
    ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity.
  • HY-104026
    L-Kynurenine Agonist 99.40%
    L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
  • HY-112629
    PDM2 Antagonist 98.88%
    PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM.
  • HY-112627
    CAY 10465 Agonist 98.48%
    CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
  • HY-109044
    Tapinarof Agonist 99.74%
    Tapinarof is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM.
  • HY-N0178
    Diosmin Agonist >98.0%
    Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).
  • HY-N0170
    Indole-3-carbinol Agonist >98.0%
    Indole-3-carbinol suppresses NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist.
  • HY-100242
    Mivotilate Activator >98.0%
    Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.
  • HY-111441
    1,4-Chrysenequinone Activator
    1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).
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