1. Immunology/Inflammation
  2. Aryl Hydrocarbon Receptor
  3. CH-223191

CH-223191 

Cat. No.: HY-12684 Purity: 98.16%
Handling Instructions

CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 blocks the binding of TCDD to AhR with an IC50 of 0.03 µM.

For research use only. We do not sell to patients.

CH-223191 Chemical Structure

CH-223191 Chemical Structure

CAS No. : 301326-22-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 122 In-stock
Estimated Time of Arrival: December 31
50 mg USD 382 In-stock
Estimated Time of Arrival: December 31
100 mg USD 622 In-stock
Estimated Time of Arrival: December 31
200 mg USD 1056 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products

    CH-223191 purchased from MCE. Usage Cited in: Toxicology. 2016 May 20;355-356:31-38.

    Western analysis of β-catenin protein level in zebrafish embryos exposed to EOM in the presence or absence of CH/CHIR (n = 3). Different letters indicate significant differences. Moreover, both CH and CHIR attenuate the EOM-induced changes in the protein level of b-catenin and in EROD activity.

    CH-223191 purchased from MCE. Usage Cited in: Chemosphere. 2018 Oct 23;216:372-378.

    AhR mediates EOM-inhibited cardiac differentiation by downregulating β-catenin expression in P19 cells. mRNA expression changes of β-catenin by Q-PCR. The concentrations of CH (CH223191, AhR antagonist) and CHIR (CHIR99021, Wnt activator) are 0.25 and 0.5 μM respectively.

    CH-223191 purchased from MCE. Usage Cited in: Chemosphere. 2018 Oct 23;216:372-378.

    AhR mediates EOM-inhibited cardiac differentiation by downregulating β-catenin expression in P19 cells. Percentage of cTnT positive cells at differentiation day 14. The concentrations of CH (CH223191, AhR antagonist) and CHIR (CHIR99021, Wnt activator) are 0.25 and 0.5 μM respectively.

    CH-223191 purchased from MCE. Usage Cited in: Chemosphere. 2018 Oct 23;216:372-378.

    AhR mediates EOM-inhibited cardiac differentiation by downregulating β-catenin expression in P19 cells. Percentage of cTnT positive cells at differentiation day 14. The concentrations of CH (CH223191, AhR antagonist) and CHIR (CHIR99021, Wnt activator) are 0.25 and 0.5 μM respectively.

    CH-223191 purchased from MCE. Usage Cited in: Chemosphere. 2018 Oct 23;216:372-378.

    Proliferation of P19 cells exposed to EOM in the presence or absence of CH. Represent images of EdU staining (red) and the quantification results.
    • Biological Activity

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    Description

    CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 blocks the binding of TCDD to AhR with an IC50 of 0.03 µM.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 35 mg/mL (104.98 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9995 mL 14.9974 mL 29.9949 mL
    5 mM 0.5999 mL 2.9995 mL 5.9990 mL
    10 mM 0.2999 mL 1.4997 mL 2.9995 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    333.39

    Formula

    C₁₉H₁₉N₅O

    CAS No.

    301326-22-7

    SMILES

    O=C(C1=CC=NN1C)NC2=CC=C(/N=N/C3=CC=CC=C3C)C=C2C

    Shipping

    Room temperature in continental US; may vary elsewhere

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    Product Name:
    CH-223191
    Cat. No.:
    HY-12684
    Quantity:

    CH-223191

    Cat. No.: HY-12684