1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Renin

Renin

Renin is a central hormone in the control of blood pressure and various other physiological functions. Renin is a hormone and an enzyme which chops the end off angiotensinogen, a circulating plasma peptide, thus creating thedecapeptide, angiotensin I. Angiotensin I is acted on by angiotensin converting enzyme (ACE), which chops another bit off to make the octapeptide, angiotensin II. Angiotensin II acts on the adrenal cortex to stimulate the release of aldosterone and aldosterone stimulates Na+ retention.

Renin is rate limiting in the production of angiotensin II (Ang II), a hormone that ultimately integrates cardiovascular and renal function in the control of blood pressure as well as salt and volume homeostasis. For instance, renin seems to be of vast importance for maintaining arterial blood pressure in the face of variations in salt intake: in mice, constant blood pressure is found during alterations in sodium intake, and this relies on controlling the activity of the renin-angiotensin system (RAS).

Renin Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-12176
    Aliskiren Inhibitor 99.16%
    Aliskiren(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM.
  • HY-12177
    Aliskiren hemifumarate Inhibitor 98.98%
    Aliskiren hemifumarate(CGP 60536 hemifumarate) is a direct renin inhibitor with IC50 of 1.5 nM.
  • HY-50769
    VTP-27999 TFA Inhibitor
    VTP-27999 TFA is an alkyl amine Renin inhibitor; VTP-27999 TFA is useful for Hypertension and End-Organ Diseases.
  • HY-N2115
    Araloside A Inhibitor
    Araloside A (Chikusetsusaponin IV) is a component of Panax japonicus, with low-renin-inhibitory activity, with an IC50 of 77.4 μM.
Isoform Specific Products

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