1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Renin

Renin

Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. The classical site of renin expression and secretion is the renal juxtaglomerular cell, where its expression is tightly regulated by physiological cues.

Prorenin and renin bound to the (pro)renin receptor not only increase the catalytic conversion of angiotensinogen to angiotensin I (Ang I), but also upregulate the expression of profibrotic genes. Renin plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin inhibitors represent an alternative to angiotensin-converting enzyme inhibitors (ACEI) for the treatment of hypertension.

Renin Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-12177
    Aliskiren hemifumarate Inhibitor 98.98%
    Aliskiren hemifumarate(CGP 60536 hemifumarate) is a direct renin inhibitor with IC50 of 1.5 nM.
  • HY-12176
    Aliskiren Inhibitor 99.16%
    Aliskiren(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM.
  • HY-76652
    VTP-27999 Hydrochloride Inhibitor 98.10%
    VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
  • HY-50769
    VTP-27999 TFA Inhibitor
    VTP-27999 TFA is an alkyl amine Renin inhibitor; VTP-27999 TFA is useful for Hypertension and End-Organ Diseases.
  • HY-50768
    VTP-27999 Inhibitor
    VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
  • HY-P1572
    Handle region peptide, rat Antagonist
    Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.
  • HY-N2115
    Araloside A Inhibitor
    Araloside A (Chikusetsusaponin IV) is a component of Panax japonicus, with low-renin-inhibitory activity, with an IC50 of 77.4 μM.
  • HY-12176AS
    Aliskiren D6 Hydrochloride Inhibitor
    Aliskiren D6 Hydrochloride (CGP 60536 D6 Hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor with IC50 of 1.5 nM.
  • HY-U00262
    ACT 178882 Inhibitor
    ACT 178882 is a new Renin inhibitor with an IC50 of 1.4 nM.
Isoform Specific Products

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