1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Adrenergic Receptor
    Renin
    5-HT Receptor
  3. Bopindolol (malonate)

Bopindolol (malonate) (Synonyms: (±)-Bopindolol (malonate))

Cat. No.: HY-B1562B
Handling Instructions

Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a prodrug of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research.

For research use only. We do not sell to patients.

Bopindolol (malonate) Chemical Structure

Bopindolol (malonate) Chemical Structure

CAS No. : 82857-38-3

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Description

Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a prodrug of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research[1][2][3][4].

IC50 & Target

Adrenergic receptor, Renin, 5-HT receptors[1][4]

In Vivo

Bopindolol (intravenous injection; 8, 16 and 32 μg/kg) causes a dose-dependent inhibition of isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs[1].
Bopindolol (0.3, 1 and 3 mg/kg; IP; single dosage) produces dose dependent decreases in diastolic blood pressure and in heart rate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (260-300 g)[2]
Dosage: 0.3, 1 and 3 mg/kg
Administration: IP; single dosage
Result: Produced dose dependent decreases in diastolic blood pressure, and the decrease of about 8 mmHg at 3 mg/kg.
Decreased the heart rate in a dose-dependent manner.
Molecular Weight

484.54

Formula

C26H32N2O7

CAS No.
SMILES

CC(N1)=CC2=C1C=CC=C2OCC(OC(C3=CC=CC=C3)=O)CNC(C)(C)C.O=C(O)CC(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Bopindolol (malonate)
Cat. No.:
HY-B1562B
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