1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Bopindolol

Bopindolol (Synonyms: (±)-Bopindolol)

Cat. No.: HY-B1562
Handling Instructions

Bopindolol is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol is a prodrug of pindolol and can be used for essential and renovascular hypertension research.

For research use only. We do not sell to patients.

Bopindolol Chemical Structure

Bopindolol Chemical Structure

CAS No. : 62658-63-3

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Description

Bopindolol is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol is a prodrug of pindolol and can be used for essential and renovascular hypertension research[1][2].

IC50 & Target[1]

β2 adrenoceptor

 

Beta-1 adrenergic receptor

 

Beta-3 adrenergic receptor

 

In Vivo

Bopindolol (intravenous injection; l8, 16 and 32 μg/kg) causes a dose-dependent inhibition of isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs[1].
Bopindolol (intraperitoneal injection; 3.0 mg/kg) reduced the diastolic blood pressure (DBP) in pithed rats. And pindolol (1.0 mg/kg) produced similar decreases in DBP of about 8 mmHg. it also produces a dose-dependent decrease in heart rate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

380.48

Formula

C₂₃H₂₈N₂O₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Bopindolol
Cat. No.:
HY-B1562
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