1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Serine/Threonine Kinase Proteins
  4. G protein-coupled receptor kinases (GRKs)

G protein-coupled receptor kinases (GRKs)

Cat. No. Product Name / Synonyms Species Source
  • HY-P75799
    GRK6 Protein, Human (sf9, His-GST)

    G protein-coupled receptor kinase 6; GRK6; GPRK6

    Human Sf9 insect cells
    GRK6 selectively phosphorylates activated G protein-coupled receptors, triggering beta-arrestin-mediated desensitization, internalization, and signaling events. It is implicated in desensitizing D2-like dopamine receptors in the striatum and chemokine receptor CXCR4, crucial for CXCL12-induced cell chemotaxis. Additionally, GRK6 phosphorylates rhodopsin (RHO) and the non-GPCR LRP6 during Wnt signaling, as observed in vitro. GRK6 Protein, Human (sf9, His-GST) is the recombinant human-derived GRK6 protein, expressed by Sf9 insect cells , with N-GST, N-His labeled tag. The total length of GRK6 Protein, Human (sf9, His-GST) is 589 a.a., with molecular weight of ~85 kDa.
Cat. No. Product Name Effect Purity