JAM-A/CD321
JAM-A (CD321), encoded by F11R, is a member of the junctional adhesion molecule family that localizes to tight junctions of endothelial and epithelial cells through its PDZ-binding cytoplasmic motif. On the luminal surface it serves as a counter-receptor for the leukocyte integrin LFA-1, guiding neutrophils and monocytes across the endothelial barrier during inflammation, and it also supports platelet interactions via self-association on platelet surfaces. JAM-A doubles as a virus receptor, since reovirus type 1 uses it for entry, and it participates in tight junction assembly and barrier permeability regulation. Epithelial overexpression of JAM-A has been linked to breast cancer progression, extending its relevance beyond leukocyte trafficking.
-
JAM-A/CD321 Recombinant Proteins (5)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
