JAM-A/CD321 Protein, Mouse (HEK293, Fc)

The JAM-A/CD321 protein is critical for the formation of epithelial tight junctions and is present at primitive cell junctions where it recruits PARD3. This association may hinder PARD3-JAM1 interaction and thus tight junction assembly. JAM-A/CD321 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived JAM-A/CD321 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of JAM-A/CD321 Protein, Mouse (HEK293, Fc) is 242 a.a., with molecular weight of ~57 kDa.

JAM-A/CD321 protein plays a crucial role in the formation of epithelial tight junctions and is present early in primordial cell junctions, where it recruits PARD3. The association of the PARD6-PARD3 complex may hinder the interaction between PARD3 and JAM1, thereby preventing the assembly of tight junctions. Furthermore, JAM-A is involved in regulating monocyte transmigration, contributing to the integrity of the epithelial barrier. Acting as a ligand for integrin alpha-L/beta-2, it participates in the transmigration of memory T-cells and neutrophils. Additionally, JAM-A is implicated in platelet activation and interacts with the ninth PDZ domain of MPDZ. Its interaction with the first PDZ domain of PARD3 may be disrupted by the association between PARD3 and PARD6B. Furthermore, JAM-A interacts with ITGAL (via I-domain), further highlighting its multifaceted involvement in cellular processes.

Mouse

HEK293

C-hFc

O88792 (M1-A242)

16456  [NCBI]

Approximately 57 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.