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Immunoglobulin-like cell adhesion molecules (IgSF CAMs) are cell adhesion molecules that belong to immunoglobulin superfamily. They are a collection of integral membrane glycoproteins that possess at least one Ig-like domain in their extracellular region, capable of heterophilic and/or homophilic binding to integrins and/or among themselves. Intercellular adhesion molecules (ICAMs), vascular cell adhesion molecules (VCAMs), MAdCAM-1 and activated leukocyte cell adhesion molecule (ALCAM), which are important in leukocyte trafficking events, also belong to IgSF CAMs. IgSF CAMs regulate important processes such as cell proliferation, differentiation and morphogenesis by initiating intracellular signaling cascades at cell-cell contact sites.
Poliovirus Receptor; Nectin-Like Protein 5; NECL-5; CD155; PVR; PVS
Human
HEK293
PVR/CD155 Protein, Human (HEK293, His) is a recombinant Human PVR expressed in HEK 293 cells with a His tag at the N-terminus. PVR, Human plays a role in cancer cell invasion and migration.
CD31/PECAM-1 Protein, a pivotal cell adhesion molecule, is essential for leukocyte transendothelial migration (TEM) in most inflammatory conditions. PECAM1 modulates bradykinin receptor BDKRB2 activation and regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Signaling through PECAM-1 leads to the activation of neutrophils, monocytes and leukocytes. CD31/PECAM-1 Protein, Human is the recombinant human-derived CD31/PECAM-1 protein, expressed by HEK293 , with tag free. The total length of CD31/PECAM-1 Protein, Human is 574 a.a., with molecular weight of ~115 kDa.
The ICAM-3/CD50 protein acts as a ligand for the leukocyte adhesion protein LFA-1 and integrin α-D/β-2, suggesting involvement in cell adhesion. ICAM-3 cooperates with integrin α-L/β-2 to facilitate phagocytosis of apoptotic neutrophils, suggesting a role in immune response regulation and apoptotic cell clearance. ICAM-3/CD50 Protein, Human (HEK293, His) is the recombinant human-derived ICAM-3/CD50 protein, expressed by HEK293 , with C-His labeled tag. The total length of ICAM-3/CD50 Protein, Human (HEK293, His) is 456 a.a., with molecular weight of 100-120 kDa.
Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (HEK293) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293 , with tag free. The total length of Nectin-2/CD112 Protein, Human (HEK293) is 329 a.a., with molecular weight of 45-55 kDa.
Signal-regulatory protein alpha; CD172a; SIRP alpha; SIRPA; MFR; SHPS1; SIRP
Human
HEK293
SIRP alpha V4/CD172a Protein, an immunoglobulin-like cell surface receptor for CD47, acts as a docking protein, facilitating the translocation of PTPN6, PTPN11, and other partners to the plasma membrane. It supports adhesion of cerebellar neurons, promotes neurite outgrowth, and facilitates glial cell attachment. Engaging in negative regulation, it modulates receptor tyrosine kinase-coupled responses, phagocytosis, mast cell activation, and dendritic cell activation. CD47 binding prevents dendritic cell maturation, inhibits cytokine production, and limits new world arenavirusinfection. SIRP alpha V4/CD172a also participates in ROS signaling, interacting with THBS1 and various proteins. SIRP alpha/CD172a Protein, Human (G75A, HEK293, His) is the recombinant human-derived SIRP alpha/CD172a protein, expressed by HEK293 , with C-His labeled tag and G75A mutation. The total length of SIRP alpha/CD172a Protein, Human (G75A, HEK293, His) is 340 a.a., with molecular weight of 45-55 kDa.
The CADM1/IGSF4A protein is an important mediator of cell-cell adhesion. It forms homodimers and interacts with CADM3 and NECTIN3. CADM1/IGSF4A Protein, Human (HEK293, His) is the recombinant human-derived CADM1/IGSF4A protein, expressed by HEK293 , with C-His labeled tag. The total length of CADM1/IGSF4A Protein, Human (HEK293, His) is 330 a.a., with molecular weight of 60-95 kDa.
CEACAM8/CD66b protein is a cell surface glycoprotein that promotes calcium-independent heterophil cell adhesion to other carcinoembryonic antigen-related cell adhesion molecules, particularly CEACAM6, in activated neutrophils Especially obvious. CEACAM8/CD66b Protein, Human (285a.a, HEK293, His) is the recombinant human-derived CEACAM8/CD66b protein, expressed by HEK293 , with C-His labeled tag. The total length of CEACAM8/CD66b Protein, Human (285a.a, HEK293, His) is 285 a.a., with molecular weight of 60-70 kDa.
CD112 Protein, Human (HEK293, His) is a recombinant human CD112 expressed in HEK 293 cells with a His tag at the N-terminus. Recombinant Human CD112 can be used as cell surface ligands for the human DNAM-1 (CD226) activating molecule.
The CEACAM6 protein is a cell surface glycoprotein that promotes calcium- and fibronectin-independent cell-cell adhesion and mediates homo- and heterosexual interactions with other carcinoembryonic antigen-related cell adhesion molecules. CEACAM6 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CEACAM6 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CEACAM6 Protein, Human (Biotinylated, HEK293, His-Avi) is 286 a.a., with molecular weight of 55-75 kDa.
The PVR/CD155 protein plays a key role in initiating natural killer (NK) cell effector functions by binding to CD96 and CD226 receptors. These interactions form mature immune synapses that trigger adhesion, lytic granule secretion, interferon-γ (IFN-γ), and cytotoxicity of activated NK cells. PVR/CD155 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived PVR/CD155 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of PVR/CD155 Protein, Human (Biotinylated, HEK293, His-Avi) is 323 a.a., with molecular weight of 55-70 kDa.
The SIRP α V4/CD172a protein is an immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein to facilitate the translocation of PTPN6, PTPN11, and other partners to the plasma membrane. It supports the adhesion of cerebellar neurons, promotes neurite growth, and promotes glial cell attachment. SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived SIRP alpha/CD172a protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, Fc-Avi) is 340 a.a., with molecular weight of 78-90 kDa.
Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (329a.a, HEK293, Fc) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Nectin-2/CD112 Protein, Human (329a.a, HEK293, Fc) is 329 a.a., with molecular weight of 70-80 kDa.
The CEACAM6 protein is a cell surface glycoprotein that promotes calcium- and fibronectin-independent cell-cell adhesion and mediates homo- and heterosexual interactions with other carcinoembryonic antigen-related cell adhesion molecules. CEACAM6 Protein, Human (HEK293, His-Avi) is the recombinant human-derived CEACAM6 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CEACAM6 Protein, Human (HEK293, His-Avi) is 286 a.a., with molecular weight of 55-75 kDa.
CEACAM1 protein is involved in various biological processes. It is phosphorylated by the insulin receptor (INSR) in response to insulin stimulation, thereby promoting insulin clearance and regulating hepatic lipogenesis. CEACAM1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CEACAM1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CEACAM1 Protein, Human (Biotinylated, HEK293, His-Avi) is 394 a.a., with molecular weight of 66-115 kDa.
Intercellular Adhesion Molecule 1; ICAM-1; Major Group Rhinovirus Receptor; CD54; ICAM1
Human
HEK293
The ICAM-1/CD54 protein plays a crucial role in cell interactions, acting as a ligand for the leukocyte adhesion protein LFA-1. It promotes leukocyte transendothelial migration by promoting the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. ICAM-1/CD54 Protein, Human (453a.a, HEK293, His) is the recombinant human-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ICAM-1/CD54 Protein, Human (453a.a, HEK293, His) is 453 a.a., with molecular weight of ~88 kDa.
rHuCoxsackievirus and adenovirus receptor/CXADR, His ; Coxsackievirus and Adenovirus Receptor; CAR; hCAR; CVB3-Binding Protein; Coxsackievirus B-Adenovirus Receptor; HCVADR; CXADR; CAR
Human
HEK293
CXADR proteins are components of the epithelial apical junction complex and, as cell adhesion molecules, are critical for the integrity of tight junctions. CXADR Protein, Human (HEK293, His) is the recombinant human-derived CXADR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CXADR Protein, Human (HEK293, His) is 218 a.a., with molecular weight of ~32.0 kDa.
Nectin-1 Protein mediates cell-cell contacts through homophilic or heterophilic trans-dimer formation, engaging in heterophilic interactions with Nectin-3 and Nectin-4. It also promotes neurite outgrowth. In microbial infection, Nectin-1 serves as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV). Nectin-1 Protein, Human (HEK293, His) is the recombinant human-derived Nectin-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Nectin-1 Protein, Human (HEK293, His) is 304 a.a., with molecular weight of 40-60 kDa.
BCAM Protein, acting as a laminin alpha-5 receptor, potentially participates in intracellular signaling, indicated by its resemblance to related proteins. BCAM Protein, Mouse (HEK293, His) is the recombinant mouse-derived BCAM protein, expressed by HEK293 , with C-His labeled tag. The total length of BCAM Protein, Mouse (HEK293, His) is 516 a.a., with molecular weight of 70-90 kDa.
ICAM-1/CD54 protein is a key player in cellular interactions, acting as a ligand for LFA-1. It facilitates endothelial cup assembly during leukocyte migration and regulates immune responses. ICAM-1 also interacts with MUC1, promoting cell aggregation, and participates in immunological synapse formation between antigen-presenting cells and T cells. These interactions showcase ICAM-1's diverse role in cellular adhesion and immune modulation. ICAM-1/CD54 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-His labeled tag. The total length of ICAM-1/CD54 Protein, Mouse (HEK293, His) is 458 a.a., with molecular weight of 80-90 kDa.
The ICAM-1/CD54 protein plays a crucial role in cell interactions, acting as a ligand for the leukocyte adhesion protein LFA-1. It promotes leukocyte transendothelial migration by promoting the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. ICAM-1/CD54 Protein, Human (HEK293, Fc) is the recombinant human-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ICAM-1/CD54 Protein, Human (HEK293, Fc) is 453 a.a., with molecular weight of ~95-135 kDa.
