Contactin-2
Contactin-2, originally named TAG-1 (transient axonal glycoprotein-1), is a GPI-anchored Ig-superfamily protein expressed on developing axons, at juxtaparanodal regions of myelinated fibers and on subsets of T cells. It mediates homophilic adhesion and interacts with the receptor protein tyrosine phosphatase beta/zeta and with contactin-1-associated complexes, influencing axon growth and glial signaling. In the immune system, TAG-1 acts as a costimulatory molecule for T cells. Autoantibodies targeting contactin-2 have been detected in patients with autoimmune encephalitis and neuropathy, making recombinant contactin-2 a key antigen for neuroimmunology diagnostics and for studies of paranodal organization.
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Contactin-2 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
