1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. TGF-beta Superfamily
  4. Smad Family

SMAD proteins are a unique group of related intracellular proteins responsible for transducing the signal induced by transforming growth factor-β (TGF-β) superfamily into the nucleus. Signals are initiated upon binding of TGF-β superfamily members to cell-surface serine/threonine kinase receptors and are then propagated by Smads. Activation of Smads results in their translocation from the cytoplasm into the nucleus, where they activate or repress transcription together with transcription factors so as to regulate target gene expression. Functional studies have demonstrated that Smads, which range from about 400 to 500 amino acids in length, can be grouped into three subfamilies, the receptor-regulated Smads (R-Smads, i.e. Smads1/2/3/5/8), the common Smads (co-Smads, i.e. Smad4) and the inhibitory Smads (I-Smads, i.e. Smads6/7), each of which plays a distinct role in the pathway. Specifically, ligand binding induces activation of TGF-β receptor complexes, which then directly phosphorylate (P) specific R-Smads. These R-Smads associate with the co-Smads Smad4 and then translocate to the nucleus, where they interact with a variety of DNA-binding partners to regulate gene expression. Conversely, the I-Smads served to dampen TGF-β signaling in a feedback manner through a variety of mechanisms. (Targeting TGF-beta/Smad )

Cat. No. Product Name / Synonyms Species Source
  • HY-P71323
    SMAD3 Protein, Human (Flag-His)

    Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3; SMAD3; MADH3

    Human E. coli
  • HY-P71324
    SMAD4 Protein, Human (His)

    Mothers Against Decapentaplegic Homolog 4; MAD Homolog 4; Mothers Against DPP Homolog 4; Deletion Target in Pancreatic Carcinoma 4; SMAD Family Member 4; SMAD 4; Smad4; hSMAD4; SMAD4; DPC4; MADH4

    Human E. coli
  • HY-P71321
    SMAD1 Protein, Human (GST)

    Mothers Against Decapentaplegic Homolog 1; MAD Homolog 1; Mothers Against DPP Homolog 1; JV4-1; Mad-Related Protein 1; SMAD Family Member 1; Transforming Growth Factor-Beta-Signaling Protein 1; BSP-1; SMAD1; BSP1; MADH1; SMAD 1; Smad1; hSMAD1; MADR1

    Human E. coli
  • HY-P71322
    SMAD2 Protein, Human (Flag-His)

    Mothers against decapentaplegic homolog 2; MAD homolog 2; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; Hsmad2; SMAD2; MADH2; MADR2

    Human E. coli
  • HY-P71536
    SMAD2 Protein, Human (His-SUMO)

    Drosophila, homolog of, MADR2; hMAD-2; HsMAD2; JV18; JV18-1; JV181; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mother against DPP homolog 2; Mothers against decapentaplegic homolog 2; Mothers against decapentaplegic, Drosophila, homolog of, 2; Mothers against DPP homolog 2; OTTHUMP00000163489; Sma and Mad related protein 2; Sma- and Mad-related protein 2 MAD; SMAD 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; SMAD2; SMAD2_HUMAN

    Human E. coli
  • HY-P73636
    SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST)

    Mothers against decapentaplegic homolog 3; mMad3; Smad3; Madh3

    Human; Rat; Mouse Sf9 insect cells
  • HY-P73637
    SMAD2 Protein, Mouse (sf9, His-GST)

    Mothers against decapentaplegic homolog 2; MAD homolog 2; hMAD-2; SMAD2; MADH2; MADR2

    Mouse Sf9 insect cells
  • HY-P74539
    SMAD5 Protein, Mouse (sf9, His-GST)

    Mothers against decapentaplegic homolog 5; Dwarfin-C; SMAD 5

    Mouse Sf9 insect cells
  • HY-P74540
    SMAD5 Protein, Mouse (sf9)

    Mothers against decapentaplegic homolog 5; Dwarfin-C; SMAD 5

    Mouse Sf9 insect cells
Cat. No. Product Name Effect Purity