SMAD3
SMAD3 is the second TGF-β/activin-responsive R-SMAD, phosphorylated by ALK5/ALK4/ALK7 and partnering with SMAD4 to regulate transcription, but functionally distinct from SMAD2: SMAD3 possesses an intact MH1 domain enabling direct high-affinity DNA binding to CAGA boxes, and participates in both developmental and postnatal contexts. In mature tissues SMAD3 dominates TGF-β responses such as induction of extracellular matrix genes (COL1A1, CTGF), epithelial-mesenchymal transition master genes (SNAI1), cytostasis and apoptosis, and the differentiation of fibroblasts and Th17/Treg lineages; Smad3-null mice develop lethal metastatic colorectal cancer in cooperation with APC loss, enhanced inflammation and accelerated wound healing, revealing dual tumor-suppressive and pro-metastatic roles. SMAD3 also binds SMAD-binding elements with transcriptional coactivators (p300/CBP) and repressors (Ski, SnoN). SMAD3 signaling is a central driver of organ fibrosis in kidney, lung and liver, motivating antisense and small-molecule anti-SMAD3 strategies in fibrotic and autoimmune disease.
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SMAD3 Recombinant Proteins (3)
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Inhibitors & Agonists (314)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
