IL-38
Interleukin-38 (IL-38, formerly IL-1F10) is the most recently characterized anti-inflammatory cytokine of the IL-1 family, sharing structural homology with IL-1 receptor antagonist and IL-36RA. It is expressed in skin, tonsils, spleen, thymus and proliferating B cells, and is upregulated in psoriatic lesional skin. IL-38 binds interleukin-36 receptor (IL-1RL2) as well as IL-1R1 and IL-1Rrp2 in certain contexts, functioning as a partial antagonist or agonist that limits IL-36- and IL-1-driven inflammation: it suppresses the production of IL-6, IL-8, IL-17 and IL-22 from stimulated macrophages, dendritic cells and Th17 cells. IL-38 can be processed by elastase and cathepsin G to variants with enhanced potency. Clinically, IL-38 levels inversely correlate with disease activity in rheumatoid arthritis, ankylosing spondylitis, psoriasis and systemic lupus erythematosus, and gain-of-function protection is suggested by genetic associations, making IL-38 a promising anti-inflammatory biologic candidate.
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IL-38 Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Fòrmula: Human
- Peso molecular: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
