GPR49
GPR49, better known as LGR5 (leucine-rich repeat-containing G-protein coupled receptor 5), is a Class A GPCR famous as a marker of actively cycling adult stem cells. Expressed in intestinal crypt base columnar cells, hair follicle bulge stem cells and other renewing tissues, LGR5 potentiates Wnt/β-catenin signaling by binding R-spondin ligands together with its relatives LGR4 and LGR6, thereby preventing RNF43/ZNRF3-mediated removal of Frizzled from the membrane. Its promoter activity faithfully labels stem cells and their progeny, which made lineage-tracing studies decisive in establishing the clonal origin of the intestinal epithelium. LGR5 is also a well-documented marker of colorectal cancer stem cells and a target for antibody-drug conjugate development.
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GPR49 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
