1. Screening Libraries
  2. Anti-Orthopoxvirus Compound Library

Anti-Orthopoxvirus Compound Library

Cat. No.: HY-L127
Library Contents: XLSX PDF SDF

Orthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. The orthopoxvirus genus consists of 12 viruses including variola virus, vaccinia virus (VV), cowpox viruses (CV), monkeypox virus, and camelpox virus. Smallpox has been eradicated worldwide in 1980, but some other orthopoxvirus, such as monkeypox virus, are still threats to human health.

There are not many drugs available for orthopoxvirus treatment. The only product currently available for treatment of complications of Orthopoxvirus infection is vaccinia immunoglobulin (VIG). In 2021, brincidofovir was approved by FDA for the treatment of smallpox and tecovirimat was approved by EMA for the treatment of monkeypox in 2022. A few active compounds including interferon and interferon inducers, and a variety of nucleosides or nucleotides have been reported to have activity against orthopoxvirus.

MCE carefully prepared a unique collection of 31 compounds reported with the anti- orthopoxvirus activity which can be used for drug screening and other research about orthopoxvirus.

MCE Anti-Orthopoxvirus Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 30 compounds supplied in 10 mM solution and 1 compounds supplied in 2 mM solution.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
100 μL/well Solution Get quote In-stock
2 × 100 μL/well Solution Get quote In-stock

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Description
& Advantages

•   A unique collection of 31 bioactive compounds with anti-orthopoxvirus for high throughput screening (HTS) and high content screening (HCS).

•   Targets include variola virus, monkeypox, cowpox viruses, etc.

•   A useful tool for the research about orthopoxvirus.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Detailed compound information with structure, IC50, and brief introduction.

•   Validated NMR and HPLC to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 31 bioactive anti-Orthopoxvirus compounds supplied as pre-dissolved Solutions or Solid.
Solution: 30 compounds supplied in 10 mM solution, 1 compounds supplied in 2 mM solution.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Composition

Anti-Orthopoxvirus Compound Library

Source: MedChem Express

Documentation

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    Product Name:
    Anti-Orthopoxvirus Compound Library
    Cat. No.:
    HY-L127
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Storage Tubes with Rack