IL-10 Receptor
The interleukin 10 receptor (IL-10R) is a type II cytokine receptor consisting of a tetramer of 2 alpha and 2 beta subunits. The α subunit, also known as IL-10RI, is a ligand-binding subunit, while the β subunit, also known as IL-10RII, is a co-subunit required for signal transduction. IL-10 receptor expression is mainly characterized in cells of the hematopoietic spectrum, such as dendritic cells, B cells, T cells, NK cells, neutrophils, monocytes, and macrophages. When IL-10R binds to its ligand IL-10, it induces phosphorylation of Jak1 and Tyk2 and activates the transcription factor STAT3. activated STAT3 monomers dimerize and enter the nucleus to induce gene expression. IL-10R-mediated signaling pathways play an important role in immune tolerance, T cell and DC development, and B cell growth and differentiation[1][2].
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IL-10 Receptor Recombinant Proteins (13)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
