2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-10 Receptor
  6. IL-10R beta

IL-10R beta

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IL-10 receptor complex consists of a heterodimer of four transmembrane chains, two of which form IL-10R alpha and two of which form IL-10R beta. IL-10R beta, originally known as the orphan receptor CRF2-4, is an essential accessory subunit for the active interleukin 10 receptor complex[1].
IL-10R beta can bind to IL-10 via the JAK-STAT pathway, and activation of the IL-10 receptor complex leads to phosphorylation of the receptor-associated proteins TYK and JAK-1, and ultimately to activation of the transcription factors STAT3, STAT1, and STAT5, which regulate the expression of IL-10-responsive genes, including c-myc, bcl-2, and bcl-xL, initiating signal transduction[2].
IL-10R beta is expressed on most cell types and is also a shared cell surface receptor required for the activation of five class II cytokines (IL-10, IL-22, IL-26, IL-28 and IFNL1), which play a key role in host defense, immune regulation. Among them, the IFNLR1/IL10R beta dimer is the receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity[3].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P74837
    IL-10R beta Protein, Mouse (HEK293, His)

    Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b

    		Mouse HEK293
    IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Mouse (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (W223-Y251) with a His tag at the C-terminus.
  • HY-P72599
    IL-10R beta Protein, Human (HEK293, His)

    Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b

    		Human HEK293
    IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses.IL-10R beta Protein, Human (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (W221-F242) with a 6*His tag at the C-terminus.
  • HY-P76414
    IL-10R beta Protein, Rat (HEK293, Fc)

    Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b

    		Rat HEK293
    IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses.IL-10R beta Protein, Rat (HEK293, Fc) is expressed by HEK 293 cells and consists of 351 amino acids (M1-V351) with a Fc tag at the C-terminus.
  • HY-P74839
    IL-10R beta Protein, Human (HEK293, His-hFc)

    Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b

    		Human HEK293
    IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Human (HEK293, His-hFc) is expressed by HEK 293 cells and has a transmembrane region (W221-F242) with a His and -hFc tag at the C-terminus.
  • HY-P74838
    IL-10R beta Protein, Mouse (HEK293, hFc)

    Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b

    		Mouse HEK293
    IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Mouse (HEK293, hFc) is expressed by HEK 293 cells and has a transmembrane region (W223-Y251) with a hFc tag at the C-terminus.
Cat. No. Product Name Effect Purity