2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Transketolase

Transketolase

Transketolase

Transketolase is a key rate-limiting enzyme in the non-oxidative branch of the pentose phosphate pathway (PPP). Transketolase is critical for energy transduction and for generating ribose for nucleic acid synthesis. Transketolase can convert ribulose 5-phosphate back into glucose 6-phosphate to generate more NADPH, and the reaction is thiamine-dependent. Transketolase has three isomer: TKT, TKTL1 and TKTL2. TKT is expressed in all investigated organisms, and is up-regulated in multiple cancer types[1][2].

Transketolase Related Products (14):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16339
    N3PT
    		Inhibitor 98.63%
    N3PT (N3-pyridyl thiamine) is a potent and selective transketolase inhibitor. N3PT is pyrophosphorylated and then binds to transketolase with an Kd value of 22 nM (Apo-TK, transketolase lacking bound thiamine).
    N3PT
  • HY-112889B
    Oxythiamine diphosphate ammonium
    		Inhibitor 98.42%
    Oxythiamin diphosphate ammonium is a potent transketolase (TK) inhibitor.
    Oxythiamine diphosphate ammonium
  • HY-E70075
    α-Glycerophosphate Dehydrogenase-Triosephosphate
    α-Glycerophosphate Dehydrogenase-Triosephosphate (GDH-TIM) is an enzyme mixture composed of glycerol phosphate dehydrogenase (GDH) and triphosphate isomerase (TIM). α-Glycerophosphate Dehydrogenase-Triosephosphate can be used to determine the activity of transketolase (TK) in hemolytic substances of red blood cells to evaluate vitamin B deficiency.
    α-Glycerophosphate Dehydrogenase-Triosephosphate
  • HY-139731
    Transketolase-IN-1
    		Inhibitor 99.06%
    Transketolase-IN-1 is a transketolase inhibitor and a herbicide. Transketolase-IN-1 inhibits weed growth and exhibits safety for maize and wheat at specified application rates. Transketolase-IN-1 can be used for the research of weed control in wheat and maize fields.
    Transketolase-IN-1
  • HY-151604
    Transketolase-IN-3
    		Inhibitor 98.94%
    Transketolase-IN-3 is a potent transketolase (TK) inhibitor. Transketolase-IN-3 has herbicidal activity and has inhibitory effects against Digitaria sanguinalis (DS) and Amaranthus retroflexus (AR). Transketolase-IN-3 can be used for the research of herbicides.
    Transketolase-IN-3
  • HY-151600
    Transketolase-IN-2
    		Inhibitor 99.83%
    Transketolase-IN-2 (compound 4w) is a potent Transketolase inhibitor. Transketolase-IN-2 shows strong inhibition of Digitaria sanguinalis and Amaranthus retroflexus (over 90% at 200 mg/L and about 80% at 100 mg/L). Transketolase-IN-2 can be used in studies of weed control.
    Transketolase-IN-2
  • HY-153090
    Transketolase-IN-4
    		Inhibitor 99.26%
    Transketolase-IN-4 is a potent inhibitor of transketolase with an IC50 value of 3.9 μM. Transketolase-IN-4 inhibits the proliferation of tumor cells including SW620, LS174T and MIA PaCa-2. Transketolase-IN-4 can be used for tumor research.
    Transketolase-IN-4
  • HY-112889
    Oxythiamine diphosphate
    Oxythiamin diphosphate is a potent transketolase (TK) inhibitor.
    Oxythiamine diphosphate
  • HY-128606
    Thiamine diphosphate analog 1
    		Activator
    Thiamine diphosphate analog 1 is an analog of thiamine diphosphate. Thiamine diphosphate is the active metabolite of vitamin B1 in organisms. Thiamine diphosphate targets ThDP-dependent enzymes such as transketolase and pyruvate dehydrogenase complex, acting as an essential coenzyme to exert an activating effect. Thiamine diphosphate assists in catalytic reactions in free form and initiates the catalytic cycles of various glucose-metabolizing enzymes. Thiamine diphosphate serves as a diagnostic biomarker and protective factor for Alzheimer's disease. Thiamine diphosphate can be used in research related to metabolism and Alzheimer's disease.
    Thiamine diphosphate analog 1
  • HY-170784
    TKL-IN-1
    		Inhibitor
    TKL-IN-1 (compound 7r) is a transketolase inhibitor and can be used as a herbicide. TKL-IN-1 can inhibit the growth of Digitaria sanguinalis (Ds) and Amaranthus retroflexus (Ar).
    TKL-IN-1
  • HY-163311
    Transketolase-IN-6
    		Inhibitor
    Transketolase-IN-6 is a potent transketolase inhibitor and a herbicide. Transketolase-IN-6 inhibits root growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis. Transketolase-IN-6 shows low phytotoxicity to wheat, maize, soybean, and cotton. Transketolase-IN-6 can be used for the research of herbicidal agent development.
    Transketolase-IN-6
  • HY-163310
    Transketolase-IN-5
    		Inhibitor
    Transketolase-IN-5 is a transketolase inhibitor and a herbicide. Transketolase-IN-5 inhibits growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis.
    Transketolase-IN-5
  • HY-169168
    Herbicidal agent 6
    		Inhibitor
    Herbicidal agent 6 (D15) is a Transketolase (TKL) inhibitor with herbicidal activity.
    Herbicidal agent 6
  • HY-180202
    Transketolase-IN-7
    		Inhibitor
    Transketolase-IN-7 (compound 4m) is a potent herbicide that exhibits inhibitory activity against C. rotundus with an IC50 of 6.66 mg/L. Transketolase-IN-7 is a transketolase (TK) inhibitor that interacts with the TK enzyme by forming hydrogen bonds. Transketolase-IN-7 can be used for research of plant herbicides.
    Transketolase-IN-7