Transketolase-IN-5 

Transketolase-IN-5 is a transketolase inhibitor and a herbicide. Transketolase-IN-5 inhibits growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis^[1].

Transketolase-IN-5 (compound 6ba) (200 mg/L; 7 days) potently inhibits root and stem growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis, with root inhibition rates of 90.2%, 82.2%, and 83.3% respectively^[1].
Transketolase-IN-5 (150 g ai/ha; 7 days) exhibits potent post-emergence herbicidal activity against Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis, with GR₅₀ values ranging from 60.901 to 107.728 g ai/ha^[1].
Transketolase-IN-5 binds to Arabidopsis thaliana transketolase with a binding free energy of 5.520 kcal/mol via multiple strong interactions, including hydrogen bonds, π-π interactions, and a halogen bond, contributing to its potent enzyme inhibitory activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

385.89

C₂₀H₂₄ClN₅O

ClC1=C(N2N=CC(C(NC3CC3)=O)=C2N(CC4CC4)CC5CC5)N=CC=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hu S, et al. Design, Synthesis, and Herbicidal Activity of Pyrazole Amide Derivatives as Potential Transketolase Inhibitors. J Agric Food Chem. 2024;72(7):3334-3341.  [Content Brief]