- Recombinant Proteins
- Cytokines and Growth Factors CD Antigens
- Interleukin & Receptors Macrophage CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins
- IL-4 Receptor IL-13 Receptor
- IL-4R alpha/CD124
IL-4R alpha/CD124
Interleukin-4 receptor alpha (CD124) is the ligand-binding alpha chain shared by the receptors for IL-4 and IL-13, cytokines that orchestrate type 2 immunity, IgE class switching, and alternative macrophage activation. Signaling proceeds through two alternative partner chains: pairing with the common gamma chain forms the type I IL-4 receptor, whereas association with IL-13R alpha 1 forms the type II receptor that responds to both cytokines. Downstream JAK-STAT6 signaling drives allergic inflammation, and CD124 is strongly expressed on endothelial cells in atopic tissues. Dupilumab binds IL-4R alpha itself, making CD124 a clinically validated intervention point in atopic dermatitis and asthma.
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IL-4R alpha/CD124 Recombinant Proteins (15)
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- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
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