1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

Opioid Receptor

Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor Related Products (35):

Cat. No. Product Name Effect Purity
  • HY-75766
    Methylnaltrexone Bromide Antagonist 98.59%
    Methylnaltrexone (Bromide) is a peripheral-acting opioid receptor antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation.
  • HY-17417
    Naloxone hydrochloride Antagonist 99.86%
    Naloxone hydrochloride is a potent opioid receptor antagonist that counters the effects of opioid overdose.
  • HY-10487
    JDTic dihydrochloride Antagonist
    JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.
  • HY-12745A
    Nalfurafine hydrochloride Agonist 98.27%
    Nalfurafine hydrochloride is a κ-opioid agonist and an anti-itch drug approved in Japan.
  • HY-13274
    JTC-801 Antagonist 99.73%
    JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ.
  • HY-101416
    Vanilpyruvic acid
    Vanilpyruvic acid is a catecholamine metabolite and precursor to vanillactic acid.
  • HY-15536A
    Cebranopadol ((1α,4α)stereoisomer)
    Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol. Cebranopadol exhibits potent agonist activity on ORL-1.
  • HY-G0021
    N-Desmethylclozapine Agonist 98.66%
    N-Desmethylclozapine is a dengue virus inhibitor, and an agonist of δ-opioid receptor.
  • HY-13044
    ADL-5859 Agonist
    ADL5859 is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel.
  • HY-76711
    Naltrexone Antagonist 99.94%
    Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
  • HY-15536
    Cebranopadol Agonist
    Cebranopadol is an analgesic NOP and opioid receptor agonist with Kis/EC50s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP)receptor, respectively.
  • HY-A0118A
    Naloxegol oxalate Antagonist 99.73%
    Naloxegol oxalate is a CYP3A4 enzyme inhibitor, is a peripherally-selective opioid antagonist, for the treatment of opioid-induced constipation.
  • HY-P0073
    Tyr-Gly-Gly-Phe-Met-OH Activator 99.89%
    Tyr-Gly-Gly-Phe-Met-OH (Methionine enkephalin) is synthetic opioid peptides.
  • HY-N0164
    Matrine Agonist 99.8%
    Matrine(Sophocarpidine; α-Matrine) is an alkaloid found in plants from the Sophora genus.
  • HY-13222
    BAN ORL 24 Antagonist
    BAN ORL 24 is a potent and selective NOP receptor antagonist. (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively).
  • HY-76710
    Naltrexone Hydrochloride Antagonist 99.98%
    Naltrexone hydrochlorideis an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
  • HY-76657A
    Alvimopan dihydrate Antagonist
    Alvimopan dihydrate(LY 246736; ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.
  • HY-B0418A
    Loperamide hydrochloride Agonist 99.39%
    Loperamide HCl is an opioid-receptor agonist used as long-acting synthetic antidiarrheals.
  • HY-B0380A
    Trimebutine maleate Agonist >98.0%
    Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects.
  • HY-P0098
    [D-Ala2]leucine-enkephalin Agonist 99.75%
    [D-Ala2]leucine-enkephalin a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin analog used to study the signaling pathway of delta opioid receptors.