1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

Opioid Receptor

Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor Related Products (43):

Cat. No. Product Name Effect Purity
  • HY-75766
    Methylnaltrexone Bromide Antagonist 98.59%
    Methylnaltrexone (Bromide) is a peripheral-acting opioid receptor antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation.
  • HY-12745A
    Nalfurafine hydrochloride Agonist 98.27%
    Nalfurafine hydrochloride is a κ-opioid agonist and an anti-itch drug approved in Japan.
  • HY-76710
    Naltrexone Hydrochloride Antagonist 99.91%
    Naltrexone hydrochlorideis an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
  • HY-101386
    PZM21 Agonist 98.54%
    PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM.
  • HY-13044
    ADL-5859 Agonist 98.81%
    ADL5859 is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel.
  • HY-15122A
    Sinomenine hydrochloride Activator >98.0%
    Sinomenine hydrochloride is a blocker of the NF-κB activation and also an activator of μ-opioid receptor.
  • HY-100122
    Bevenopran Antagonist
    Bevenopran is a peripheral μ-opioid receptor antagonist.
  • HY-107384
    Asimadoline Agonist 99.36%
    Asimadoline is a potent κ opioid receptor agonist with IC50s of 5.6 and 1.2 nM for guinea pig and human recombinant κ opioid receptor, respectively.
  • HY-P0073
    Tyr-Gly-Gly-Phe-Met-OH Activator 99.89%
    Tyr-Gly-Gly-Phe-Met-OH (Methionine enkephalin) is synthetic opioid peptides.
  • HY-10487
    JDTic dihydrochloride Antagonist 98.18%
    JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.
  • HY-B0418A
    Loperamide hydrochloride Agonist 99.39%
    Loperamide HCl is an opioid-receptor agonist used as long-acting synthetic antidiarrheals.
  • HY-13274
    JTC-801 Antagonist 99.20%
    JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2 nM.
  • HY-15536
    Cebranopadol Agonist 98.24%
    Cebranopadol is an analgesic NOP and opioid receptor agonist with Kis/EC50s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP) receptor, respectively.
  • HY-G0021
    N-Desmethylclozapine Agonist 98.66%
    N-Desmethylclozapine is a dengue virus inhibitor, and an agonist of δ-opioid receptor.
  • HY-101718
    LY-2456302 Antagonist 99.24%
    LY-2456302 is a potent and centrally-penetrant kappa opioid receptor antagonist with a Ki of 0.807 nM.
  • HY-N0164
    Matrine Agonist >98.0%
    Matrine(Sophocarpidine; α-Matrine) is an alkaloid found in plants from the Sophora genus.
  • HY-101177
    Naltrindole hydrochloride Antagonist 99.68%
    Naltrindole hydrochloride is a highly potent and selective non-peptide δ opioid receptor antagonist with a Ki of 0.02 nM.
  • HY-13222
    BAN ORL 24 Antagonist
    BAN ORL 24 is a potent and selective NOP receptor antagonist. (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively).
  • HY-P0183
    Nociceptin Agonist 99.79%
    Nociceptin, a heptadecapeptide, is the endogenous ligand of the nociceptin receptor, acting as a potent anti-analgesic.
  • HY-P1013
    Deltorphin 2 Agonist 98.20%
    Deltorphin 2 is a selective peptide agonist for the δ opioid receptor.