Tyr-Gly-Gly-Phe-Met-OH
Based on 4 publication(s) in Google Scholar
Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 58569-55-4
- Formula: C27H35N5O7S
- Molecular Weight:573.66
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
![[Leu5]-Enkephalin](https://file.medchemexpress.com/product_pic/hy-p0288.gif)
HY-P0288
[Leu5]-Enkephalin
-
![[Leu5]-Enkephalin, amide](https://file.medchemexpress.com/product_pic/hy-p1470.gif)
HY-P1470
[Leu5]-Enkephalin, amide
-
HY-P1337
Dynorphin B (1-13)
-
HY-P0179
β-Casomorphin, bovine
-
HY-P1596
Gluten Exorphin C
-
HY-13715
Norepinephrine
-
HY-P1331
BAM-22P
-
HY-P0210
DAMGO
-
HY-P1087
Adrenorphin
-
![[D-Ala2]leucine-enkephalin](https://file.medchemexpress.com/product_pic/hy-p0098.gif)
HY-P0098
[D-Ala2]leucine-enkephalin
-
HY-P1333
Dynorphin A
-
HY-P0197
Neurokinin A
Publications Citing Use of MedChemExpress (MCE) Tyr-Gly-Gly-Phe-Met-OH
MoreAll Opioid Receptor Isoforms
More
Biological Activity
Opioid Receptor[1].
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
1.03 nM
Compound: [Met5]-enkephalin
|
Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay
Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay
|
[PMID: 22197670] |
| HEK293 | EC50 |
1.03 nM
Compound: Met-enk
|
Agonist activity at human recombinant delta opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay
Agonist activity at human recombinant delta opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay
|
[PMID: 19362480] |
| HEK293 | IC50 |
13 nM
Compound: Met-Enk
|
Agonist activity at mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay
Agonist activity at mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay
|
[PMID: 26465170] |
| HEK293 | IC50 |
6.4 nM
Compound: Met-Enk
|
Agonist activity at delta receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay
Agonist activity at delta receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay
|
[PMID: 26465170] |
Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 58569-55-4
-
Appearance Solid
-
Molecular Weight 573.66
-
Formula C27H35N5O7S
-
Color White to off-white
-
Synonyms
Met-Enkephalin; Methionine enkephalin; Metenkefalin
-
Sequence
Tyr-Gly-Gly-Phe-Met
-
Sequence Shortening
YGGFM
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
-
Journal Impact Factor
-
Most Recent
-
Nature
2024 Jul;631(8021):686-693. PMID: 38961287 -
Proc Natl Acad Sci U S A
Methionine-specific nonreversible bioconjugation: Advancing precision protein modification. [Abstract]2026 Feb 17;123(7):e2519038123. PMID: 41665996 -
J Leukoc Biol
Anti-inflammatory and metabolic reprogramming effects of MENK produce antitumor response in CT26 tumor-bearing mice. [Abstract]2020 Jul;108(1):215-228. PMID: 31994797 -
Solvent & Solubility
DMSO : ≥ 40 mg/mL (69.73 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5 mg/mL (8.72 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.7432 mL | 8.7160 mL | 17.4319 mL | 43.5798 mL |
| 5 mM | 0.3486 mL | 1.7432 mL | 3.4864 mL | 8.7160 mL | |
| DMSO | 10 mM | 0.1743 mL | 0.8716 mL | 1.7432 mL | 4.3580 mL |
| 15 mM | 0.1162 mL | 0.5811 mL | 1.1621 mL | 2.9053 mL | |
| 20 mM | 0.0872 mL | 0.4358 mL | 0.8716 mL | 2.1790 mL | |
| 25 mM | 0.0697 mL | 0.3486 mL | 0.6973 mL | 1.7432 mL | |
| 30 mM | 0.0581 mL | 0.2905 mL | 0.5811 mL | 1.4527 mL | |
| 40 mM | 0.0436 mL | 0.2179 mL | 0.4358 mL | 1.0895 mL | |
| 50 mM | 0.0349 mL | 0.1743 mL | 0.3486 mL | 0.8716 mL | |
| 60 mM | 0.0291 mL | 0.1453 mL | 0.2905 mL | 0.7263 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tyr-Gly-Gly-Phe-Met-OH Related Classifications
HY-P0073 Related Classifications
Powered by Bioz