1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

Tyr-Gly-Gly-Phe-Met-OH (Synonyms: Met-Enkephalin; Methionine enkephalin)

Cat. No.: HY-P0073 Purity: 99.89%
Handling Instructions

Tyr-Gly-Gly-Phe-Met-OH (Methionine enkephalin) is synthetic opioid peptides.

For research use only. We do not sell to patients.
Tyr-Gly-Gly-Phe-Met-OH Chemical Structure

Tyr-Gly-Gly-Phe-Met-OH Chemical Structure

CAS No. : 58569-55-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
10 mg USD 60 In-stock
25 mg USD 102 In-stock
50 mg USD 168 In-stock
100 mg USD 264 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Tyr-Gly-Gly-Phe-Met-OH (Methionine enkephalin) is synthetic opioid peptides. Target: Opioid Receptor Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. Clinical trial studies in cancer patients have shown that MENK activates immune cells directly and by inhibiting regulatory T-cells (Tregs). MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems. Due to the apparent role of MENK in cancer therapy we reviewed herein, the research undertaken with MENK in recent years; which has advanced our understanding of the role MENK has in cancer progression and its relationship to immunity, supporting MENK as a new strategy for cancer immunotherapy. MENK is well-known as a long-lasting analgesic, and has an important role in modulating pain sensitivity.

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.7432 mL 8.7160 mL 17.4319 mL
5 mM 0.3486 mL 1.7432 mL 3.4864 mL
10 mM 0.1743 mL 0.8716 mL 1.7432 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight







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Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 40 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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