1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

Tyr-Gly-Gly-Phe-Met-OH (Synonyms: Met-Enkephalin; Methionine enkephalin)

Cat. No.: HY-P0073 Purity: 99.89%
Data Sheet SDS Handling Instructions

Tyr-Gly-Gly-Phe-Met-OH (Methionine enkephalin) is synthetic opioid peptides.

For research use only. We do not sell to patients.
Tyr-Gly-Gly-Phe-Met-OH Chemical Structure

Tyr-Gly-Gly-Phe-Met-OH Chemical Structure

CAS No. : 58569-55-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
10 mg $50 In-stock
25 mg $85 In-stock
50 mg $140 In-stock
100 mg $220 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Tyr-Gly-Gly-Phe-Met-OH (Methionine enkephalin) is synthetic opioid peptides. Target: Opioid Receptor Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. Clinical trial studies in cancer patients have shown that MENK activates immune cells directly and by inhibiting regulatory T-cells (Tregs). MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems. Due to the apparent role of MENK in cancer therapy we reviewed herein, the research undertaken with MENK in recent years; which has advanced our understanding of the role MENK has in cancer progression and its relationship to immunity, supporting MENK as a new strategy for cancer immunotherapy. MENK is well-known as a long-lasting analgesic, and has an important role in modulating pain sensitivity.

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.7432 mL 8.7160 mL 17.4319 mL
5 mM 0.3486 mL 1.7432 mL 3.4864 mL
10 mM 0.1743 mL 0.8716 mL 1.7432 mL
References
M.Wt

573.66

Formula

C₂₇H₃₅N₅O₇S

CAS No.

58569-55-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 40 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Tyr-Gly-Gly-Phe-Met-OH
Cat. No.:
HY-P0073
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