1. GPCR/G Protein Neuronal Signaling
  2. Opioid Receptor
  3. Tyr-Gly-Gly-Phe-Met-OH

Tyr-Gly-Gly-Phe-Met-OH  (Synonyms: Met-Enkephalin; Methionine enkephalin; Metenkefalin)

Cat. No.: HY-P0073 Purity: 99.57%
COA Handling Instructions

Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Tyr-Gly-Gly-Phe-Met-OH Chemical Structure

Tyr-Gly-Gly-Phe-Met-OH Chemical Structure

CAS No. : 58569-55-4

Size Price Stock Quantity
10 mM * 1 mL in Water USD 66 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
5 mg USD 38 In-stock
10 mg USD 60 In-stock
25 mg USD 102 In-stock
50 mg USD 168 In-stock
100 mg USD 264 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Tyr-Gly-Gly-Phe-Met-OH

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.

IC50 & Target

Opioid Receptor[1].

In Vitro

Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight








Sequence Shortening



Room temperature in continental US; may vary elsewhere.


Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 40 mg/mL (69.73 mM)

H2O : 6.67 mg/mL (11.63 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7432 mL 8.7160 mL 17.4319 mL
5 mM 0.3486 mL 1.7432 mL 3.4864 mL
10 mM 0.1743 mL 0.8716 mL 1.7432 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
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Tyr-Gly-Gly-Phe-Met-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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