1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Ephrin/Eph Family
  4. Ephrins

Ephrins are a family of ligands that bind to the Eph receptors, the largest family of receptor tyrosine kinases. Ephrins and the Eph family are membrane-bound molecules that mediate short-range axon guidance via cell-cell contacts. The ephrins fall into two broad classes, the ephrinAs (ephrins A1-A6), which are attached to the cell membrane by a glycosyl phosphatidylinositol (GPI) moiety, and the ephrinBs (ephrins B1-B3), which span the cellular membrane and possess a cytoplasmic signaling domain. The ephrins and its receptors, Eph receptor, are both expressed on the surface of cells. Unlike ligands for other receptor tyrosine kinases, the Ephrins are unable act as soluble mediators, but rather must be membrane-bound in order to activate their receptors (membrane linkage seemingly serves to cluster the ligands, and this clustering is required for their activity).

Cat. No. Product Name / Synonyms Species Source
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