1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Ephrin/Eph Family
  4. Ephrins

Ephrins are a family of ligands that bind to the Eph receptors, the largest family of receptor tyrosine kinases. Ephrins and the Eph family are membrane-bound molecules that mediate short-range axon guidance via cell-cell contacts. The ephrins fall into two broad classes, the ephrinAs (ephrins A1-A6), which are attached to the cell membrane by a glycosyl phosphatidylinositol (GPI) moiety, and the ephrinBs (ephrins B1-B3), which span the cellular membrane and possess a cytoplasmic signaling domain. The ephrins and its receptors, Eph receptor, are both expressed on the surface of cells. Unlike ligands for other receptor tyrosine kinases, the Ephrins are unable act as soluble mediators, but rather must be membrane-bound in order to activate their receptors (membrane linkage seemingly serves to cluster the ligands, and this clustering is required for their activity).

Cat. No. Product Name / Synonyms Species Source
  • HY-P70164
    Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His)

    rHuEphrin-A1, His; Ephrin-A1; EPH-Related Receptor Tyrosine Kinase Ligand 1; LERK-1; Immediate Early Response Protein B61; Tumor Necrosis Factor Alpha-Induced Protein 4; TNF Alpha-Induced Protein 4; EFNA1; EPLG1; LERK1; TNFAIP4

    Human HEK293
    Ephrin-A1/EFNA1 Protein is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family (EphA2). EFNA1 exerts its function largely through interactions with EphA2. EFNA1 exists in a soluble form as well as a glycophosphatidylinositol (GPI) membrane attached form. EFNA1 acts as a membrane-bound, GPI-anchored protein capable of mediating juxtacrine signalling and requiring membrane attachment or clustering/oligomerization. EFNA1 is a novel TNF-inducible protein. EFNA1 efficiently binds to the EphA8 receptor expressed in NIH3T3 fibroblasts. EFNA1 stimulates PI3K activity via direct interaction of EphA2 with the p85 subunit of PI3K. EFNA1 can both inhibit and stimulate oncogenesis, depending on the cellular context. Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His) is the recombinant human-derived Ephrin-A1/EFNA1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His) is 164 a.a., with molecular weight of 25-30 kDa.
  • HY-P70377
    Ephrin-B2/EFNB2 Protein, Human (HEK293, His)

    rHuEphrin-B2/EFNB2, His; Ephrin-B2; EPH-Related Receptor Tyrosine Kinase Ligand 5; LERK-5; HTK Ligand; HTK-L; EFNB2; EPLG5; HTKL; LERK5

    Human HEK293
    Ephrin-B2/EFNB2 is a key transmembrane ligand of Eph receptors that coordinates migration, repulsion, and adhesion in developing neurons, blood vessels, and epithelia. It induces bidirectional signaling, binding to EPHA4, EPHA3 and EPHB4, which is critical for cardiac morphogenesis and angiogenesis. Ephrin-B2/EFNB2 Protein, Human (HEK293, His) is the recombinant human-derived Ephrin-B2/EFNB2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-B2/EFNB2 Protein, Human (HEK293, His) is 202 a.a., with molecular weight of 30-40 kDa.
  • HY-P73009
    Ephrin-A3/EFNA3 Protein, Mouse (HEK293, His)

    Ephrin-A3; EFL-2; EHK1-L; LERK-3; EFNA3; EFL2; EPLG3

    Mouse HEK293
    Ephrin-A3/EFNA3 Protein, a GPI-bound ligand, interacts with Eph receptors, playing a critical role in neuronal, vascular, and epithelial development. It binds adjacent Eph receptors, initiating bidirectional signaling. Ephrin-A3/EFNA3 also activates EPHA8, contributing to its regulatory functions in migration, repulsion, and adhesion. Ephrin-A3/EFNA3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Ephrin-A3/EFNA3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin-A3/EFNA3 Protein, Mouse (HEK293, His) is 183 a.a., with molecular weight of ~38 kDa.
  • HY-P75228
    Ephrin B3 Protein, Mouse (HEK293, His)

    EFNB3; EPH-related receptor tyrosine kinase ligand 8; Ephrin B3; LERK-8; ELK-L3

    Mouse HEK293
    Ephrin B3 protein, a transmembrane ligand, binds adjacent Eph receptors, triggering bidirectional signaling. It induces axon collapse in vitro and may influence axon guidance and orientation. Ephrin B3 interacts with GRIP1 and GRIP2, suggesting regulatory roles in development and cellular functions. Ephrin B3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Ephrin B3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin B3 Protein, Mouse (HEK293, His) is 200 a.a., with molecular weight of ~23.5 kDa.
  • HY-P77356
    EFNB2A Protein, zebrafish (HEK293, His)

    Ephrin-B2a; efnb2

    Others HEK293
    The EFNB2A protein is a cell surface ligand of the Eph receptor that critically regulates migration, repulsion, and adhesion in neuronal, vascular, and epithelial development. EFNB2A Protein, zebrafish (HEK293, His) is the recombinant EFNB2A protein, expressed by HEK293 , with C-His labeled tag. The total length of EFNB2A Protein, zebrafish (HEK293, His) is 198 a.a., with molecular weight of ~30-40 kDa.
  • HY-P700609
    Ephrin-B1/EFNB1 Protein, Human (HEK293, C-hFc)

    Ephrin-B1; EFL-3; ELK-L; LERK-2; Ephrin-B1 CTF; EFNB1; EFL3; EPLG2; LERK2

    Human HEK293
    Ephrin-B1/EFNB1 Protein, a type I membrane protein, acts as a ligand for Eph-related receptor tyrosine kinases, potentially influencing cell adhesion and contributing to nervous system development. With ubiquitous expression, it is notably present in fat, placenta, and various tissues, showcasing its broad impact on diverse cellular and physiological contexts. Ephrin-B1/EFNB1 Protein, Human (HEK293, C-hFc) is the recombinant human-derived Ephrin-B1/EFNB1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin-B1/EFNB1 Protein, Human (HEK293, C-hFc) is 210 a.a., with molecular weight of approximately 58.76 kDa.
  • HY-P73017
    Ephrin-B2/EFNB2 Protein, Mouse (HEK293, Fc)

    Ephrin-B2; LERK-5; HTK-L; EFNB2; EPLG5

    Mouse HEK293
    Ephrin-B2/EFNB2 Protein is a transmembrane ligand for Eph receptors, mediating bidirectional signaling and binding to EPHA4, EPHA3, and EPHB4. It regulates cell adhesion, migration, heart morphogenesis, angiogenesis, and axon orientation. It also interacts with PDZRN3. Ephrin-B2/EFNB2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Ephrin-B2/EFNB2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin-B2/EFNB2 Protein, Mouse (HEK293, Fc) is 204 a.a., with molecular weight of 55-63 kDa.
  • HY-P70373
    Ephrin-A1/EFNA1 Protein, Mouse (HEK293, Fc-His)

    rMuEphrin-A1/EFNA1, Fc-His; EPH-related receptor tyrosine kinase ligand 1; Immediate early response protein B61; Epgl1; Epl1; Lerk1

    Mouse HEK293
    The Ephrin-A1/EFNA1 protein is a GPI-binding ligand critical for migration, repulsion, and adhesion in developing neurons, blood vessels, and epithelia. It binds to nearby Eph receptors, initiating bidirectional signaling. Ephrin-A1/EFNA1 Protein, Mouse (HEK293, Fc-His) is the recombinant mouse-derived Ephrin-A1/EFNA1 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag. The total length of Ephrin-A1/EFNA1 Protein, Mouse (HEK293, Fc-His) is 164 a.a., with molecular weight of ~45-65 kDa.
  • HY-P70378
    Ephrin-B2/EFNB2 Protein, Mouse (HEK293, Fc-His)

    rMuEphrin-B2/EFNB2, Fc-His; Ephrin-B2; ELF-2; EPH-related receptor tyrosine kinase ligand 5; HTK ligand; Elf2; Epl5; Eplg5; Htkl; Lerk5.

    Mouse HEK293
    Ephrin-B2/EFNB2 Protein is a transmembrane ligand for Eph receptors, mediating bidirectional signaling and binding to EPHA4, EPHA3, and EPHB4. It regulates cell adhesion, migration, heart morphogenesis, angiogenesis, and axon orientation. It also interacts with PDZRN3. Ephrin-B2/EFNB2 Protein, Mouse (HEK293, Fc-His) is the recombinant mouse-derived Ephrin-B2/EFNB2 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag. The total length of Ephrin-B2/EFNB2 Protein, Mouse (HEK293, Fc-His) is 199 a.a., with molecular weight of 65-80 kDa.
  • HY-P70379
    Ephrin-A5/EFNA5 Protein, Human (HEK293, Fc)

    rHuEphrin-A5/EFNA5, Fc; Ephrin-A5; EPLG7; LERK7; EFNA5; LERK-7; EPH-related receptor tyrosine kinase ligand 7; AL-1

    Human HEK293
    Ephrin-A5/EFNA5 Protein, a cell surface GPI-bound ligand, crucially interacts with Eph receptors, inducing bidirectional signaling and regulating adhesion, organization, and development in neurons, vasculature, and epithelium. It forms complexes with EPHA3, EPHA8, and ADAM10, impacting internalization and function, while also mediating communication in pancreatic islet cells and influencing brain development. Ephrin-A5/EFNA5 Protein, Human (HEK293, Fc) is the recombinant human-derived Ephrin-A5/EFNA5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin-A5/EFNA5 Protein, Human (HEK293, Fc) is 183 a.a., with molecular weight of 55-60 kDa.
  • HY-P70402
    Ephrin-B1/EFNB1 Protein, Human (HEK293, His)

    rHuEphrin-B1/EFNB1, His; Ephrin-B1; EFL-3; ELK ligand; EPH-related receptor tyrosine kinase ligand 2; LERK-2

    Human HEK293
    Ephrin-B1/EFNB1 Protein, a transmembrane ligand, interacts with Eph receptors, facilitating bidirectional signaling. It binds EPHB1/ELK and EPHB2/3, inducing axon collapse and growth cone orientation. EFNB1 also interacts with GRIP1/2, TLE1, and enhances ZHX2's transcriptional repression activity. These interactions highlight EFNB1's role in diverse developmental processes. Ephrin-B1/EFNB1 Protein, Human (HEK293, His) is the recombinant human-derived Ephrin-B1/EFNB1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-B1/EFNB1 Protein, Human (HEK293, His) is 205 a.a., with molecular weight of ~34.0 kDa.
  • HY-P72662
    Ephrin-A1/EFNA1 Protein, Human (HEK293, Fc)

    Ephrin-A1; LERK-1; EFNA1; EPLG1; TNFAIP4

    Human HEK293
    The Ephrin-A1/EFNA1 protein is a GPI-binding ligand that interacts with Eph receptors and is critical for migration and adhesion. It recruits VAV2, VAV3, and PI3 kinase p85 subunits through EPHA2 phosphorylation, activating RAC1 GTPase for endothelial cell migration. Ephrin-A1/EFNA1 Protein, Human (HEK293, Fc) is the recombinant human-derived Ephrin-A1/EFNA1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin-A1/EFNA1 Protein, Human (HEK293, Fc) is 164 a.a., with molecular weight of 55-60 kDa.
  • HY-P73006
    Ephrin-A3/EFNA3 Protein, Human (HEK293)

    Ephrin-A3; EFL-2; EHK1-L; LERK-3; EFNA3; EFL2; EPLG3

    Human HEK293
    Ephrin-A3/EFNA3 proteins are cell surface GPI-binding ligands of Eph receptors and play a key role in regulating key cellular processes such as migration, repulsion, and adhesion during neuronal, vascular, and epithelial development. As a promiscuous binder, Ephrin-A3 binds to Eph receptors on neighboring cells, initiating contact-dependent bidirectional signaling to neighboring cells. Ephrin-A3/EFNA3 Protein, Human (HEK293) is the recombinant human-derived Ephrin-A3/EFNA3 protein, expressed by HEK293 , with tag free. The total length of Ephrin-A3/EFNA3 Protein, Human (HEK293) is 191 a.a., with molecular weight of 35-40 kDa.
  • HY-P73011
    Ephrin-A4/EFNA4 Protein, Mouse (HEK293, His)

    Ephrin-A4; LERK-4; EFNA4; EPLG4

    Mouse HEK293
    Ephrin-A4/EFNA4 proteins are cell surface GPI-binding ligands of Eph receptors that serve as critical mediators in a variety of cellular processes critical for migration, repulsion, and adhesion during neuronal, vascular, and epithelial development. As a promiscuous binder, Ephrin-A4 binds to Eph receptors on neighboring cells, stimulating contact-dependent bidirectional signaling to neighboring cells. Ephrin-A4/EFNA4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Ephrin-A4/EFNA4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin-A4/EFNA4 Protein, Mouse (HEK293, His) is 151 a.a., with molecular weight of ~25 kDa.
  • HY-P73014
    Ephrin-A5/EFNA5 Protein, Rat (HEK293, His)

    Ephrin-A5; AL-1; EPH-related receptor tyrosine kinase ligand 7; LERK-7; EFNA5; EPLG7

    Rat HEK293
    The Ephrin-A5/EFNA5 protein is an important cell surface ligand that plays an important role in neuronal, vascular, and epithelial development. It binds to Eph receptors, initiating bidirectional signaling and regulating intercellular adhesion, cytoskeletal organization, and lens transparency. Ephrin-A5/EFNA5 Protein, Rat (HEK293, His) is the recombinant rat-derived Ephrin-A5/EFNA5 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin-A5/EFNA5 Protein, Rat (HEK293, His) is 182 a.a., with molecular weight of ~27 kDa.
  • HY-P73020
    Ephrin-B2/EFNB2 Protein, Rat (HEK293, His)

    Ephrin-B2; LERK-5; HTK-L; EFNB2; EPLG5

    Rat HEK293
    Ephrin-B2 (EFNB2) is a member of the ephrin family. Ephrin-B2/EFNB2 Protein, Rat (HEK293, His) is the recombinant rat-derived Ephrin-B2/EFNB2 protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of Ephrin-B2/EFNB2 Protein, Rat (HEK293, His) is 201 a.a., with molecular weight of 33-39 kDa.
  • HY-P73025
    Ephrin-A1/EFNA1 Protein, Rat (HEK293, His)

    Ephrin-A1; LERK-1; TNF alpha-induced protein 4; EFNA1; EPLG1; TNFAIP4

    Rat HEK293
    The Ephrin-A1/EFNA1 protein is a cell surface GPI-binding ligand of the Eph receptor and is involved in migration, repulsion, and adhesion during development. Ephrin-A1/EFNA1 Protein, Rat (HEK293, His) is the recombinant rat-derived Ephrin-A1/EFNA1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin-A1/EFNA1 Protein, Rat (HEK293, His) is 164 a.a., with molecular weight of ~23 kDa.
  • HY-P73027
    Ephrin-B1/EFNB1 Protein, Mouse (HEK293, Fc)

    Ephrin-B1; EFL-3; ELK-L; LERK-2; Ephrin-B1 CTF; EFNB1; EFL3; EPLG2; LERK2

    Mouse HEK293
    Ephrin-B1 (EFNB1) protein binds to Eph family receptors, enabling signaling between receptor-expressing cells and cells with EFNB1. It is crucial for neuronal axon growth and expressed in various tissues like the adult lung and colon, highlighting its widespread presence and importance in mediating cellular interactions. Ephrin-B1/EFNB1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Ephrin-B1/EFNB1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin-B1/EFNB1 Protein, Mouse (HEK293, Fc) is 200 a.a., with molecular weight of 55-75 kDa.
  • HY-P75230
    Ephrin-B2/EFNB2 Protein, Canine (HEK293, His)

    Ephrin-B2; LERK-5; HTK-L; EFNB2; EPLG5

    Canine HEK293
    Ephrin-B2/EFNB2 Protein, a member of the ephrin family, serves as a transmembrane ligand, interacting with its Eph receptor to initiate bidirectional signaling. Crucial in developmental processes like tissue boundary formation, axon guidance, angiogenesis, and synaptic plasticity, Ephrin-B2/EFNB2 is implicated in conditions like cancer, cardiovascular diseases, and neurological disorders, making it a potential therapeutic target. Ephrin-B2/EFNB2 Protein, Canine (HEK293, His) is the recombinant canine-derived Ephrin-B2/EFNB2 protein, expressed by HEK293, with C-His labeled tag. The total length of Ephrin-B2/EFNB2 Protein, Canine (HEK293, His) is 202 a.a., with molecular weight of ~25-35 kDa.
  • HY-P75755
    Ephrin A5 Protein, Canine (HEK293, Fc)

    Ephrin-A5; AL-1; EPH-related receptor tyrosine kinase ligand 7; LERK-7; EFNA5; EPLG7

    Canine HEK293
    Ephrin-A5/EFNA5 Protein is a member of the ephrin family of proteins, which are transmembrane proteins that act as both ligands and receptors. It interacts with Eph receptors on adjacent cells through bidirectional signaling, which triggers a series of intracellular events that regulate various cellular processes, including cell adhesion, repulsion, and migration. Ephrin-A5/EFNA5 Protein plays a crucial role in the development of neurons, blood vessels, epithelia, embryonic development, and fertility. Ephrin A5 Protein, Canine (HEK293, Fc) is the recombinant canine-derived Ephrin A5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin A5 Protein, Canine (HEK293, Fc) is 183 a.a., with molecular weight of ~59 kDa.
Cat. No. Product Name Effect Purity