Ephrin B2
Ephrin-B2, encoded by EFNB2, is a transmembrane ephrin with a tyrosine-containing cytoplasmic tail and a PDZ-binding motif that support robust reverse signaling. Its hallmark function is vascular identity: ephrin-B2 is expressed specifically on arterial endothelium, where interaction with venous EphB4 draws the artery-vein boundary during angiogenesis, and it is likewise required for lymphatic development. In bone, ephrin-B2 on osteoclasts and EphB4 on osteoblasts form a bidirectional coupling system that balances resorption and formation. Ephrin-B2 also directs neural crest migration, somite segmentation and synaptic plasticity. Dysregulated ephrin-B2 expression has been reported in tumors and in infectious disease models, making it one of the most intensively studied B-class ligands.
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Ephrin B2 Recombinant Proteins (13)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
