EFNB2A Protein, zebrafish (HEK293, Fc)

The EFNB2A protein is a cell surface ligand of the Eph receptor that critically regulates migration, repulsion, and adhesion in neuronal, vascular, and epithelial development. EFNB2A Protein, zebrafish (HEK293, Fc) is the recombinant EFNB2A protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EFNB2A Protein, zebrafish (HEK293, Fc) is 222 a.a., with molecular weight of ~48.9 kDa.

EFNB2A, a cell surface transmembrane ligand for Eph receptors, plays a crucial role in neuronal, vascular, and epithelial development by binding promiscuously to Eph receptors on adjacent cells. This interaction initiates contact-dependent bidirectional signaling into neighboring cells, with forward signaling occurring downstream of the receptor and reverse signaling downstream of the ephrin ligand. EFNB2A, together with EphB4, may hold significance in heart morphogenesis and angiogenesis by regulating cell adhesion and migration. The protein's binding to the receptor tyrosine kinase EphB4 highlights its involvement in these essential developmental processes.

Others

HEK293

C-hFc

O73874 (M1-A222)

30219  [NCBI]

Approximately 48.9 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.