Signaling Pathway

PKA

PKA

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Protein kinase A (PKA) is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase . Protein kinase A has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.

PKA Inhibitors & Modulators (9)

Product Name Catalog No. Brief Description
Afuresertib

HY-15727

Afuresertib (GSK2110183) is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM).

AZD5363

HY-15431

AZD5363, a novel pyrrolopyrimidine-derived compound, inhibits all AKT isoforms (IC50 <10 nM).

Bucladesine calcium salt

HY-B0764A

Bucladesine calcium salt(DC2797 calcium salt) is a membrane permeable selective activator of PKA.

Bucladesine sodium salt

HY-B0764

Bucladesine is a membrane permeable selective activator of PKA.

CCG215022

HY-18991

CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.

H 89

HY-15979

H 89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM;  weak inhibition on PKG, PKC, CK1, CK2 and others kinases.

H-89 dihydrochloride

HY-15979A

H 89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM;  weak inhibition on PKG, PKC, CK1, CK2 and others kinases.

Staurosporine

HY-15141

Staurosporine is a prototypical potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.

Synaptamide

HY-100197

Synaptamide is a potent mediator for neurogenic differentiation of NSCs acting through PKA/CREB activation.