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Bucladesine hemicalcium

(Synonyms: Dibutyryl cAMP hemicalcium; DBcAMP hemicalcium)
49 Cited Publications
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Based on 49 publication(s) in Google Scholar

Bucladesine (Dibutyryl cAMP; DBcAMP) hemicalcium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation.

For research use only. We do not sell to patients.

  • Purity: 98.58%
  • CAS No.: 938448-87-4
  • Formula: C18H24N5O8P·1/2Na
  • Molecular Weight:489.43
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Bucladesine hemicalcium Chemical Structure
    Bucladesine hemicalcium Chemical Structure
  • Experimental Validation Results for Bucladesine hemicalcium
  • Experimental Validation Results for Bucladesine hemicalcium
  • Experimental Validation Results for Bucladesine hemicalcium
  • Experimental Validation Results for Bucladesine hemicalcium
  • Experimental Validation Results for Bucladesine hemicalcium
CAS No.: 938448-87-4
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  • Bucladesine hemicalcium Chemical Structure
    Bucladesine hemicalcium Chemical Structure
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    Bucladesine hemicalcium purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2024 Aug 19;20(11):4476-4495. [Abstract]

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     The protein expression of p-AMPK (S173), p-AMPK (T172) and AMPK of HT-29 cells treated with 5-HT, either alone or in combination with H-89 (1 μM) and dbcAMP (1 μM).

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    Bucladesine hemicalcium purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Sep 15:243:113982. [Abstract]

    Customer Validation
     H295R cells were treated with 30 μM BHPF in the absence or presence of 10 μM forskolin (FSK) or 100 μM dbcAMP for 48 h and evaluated by Western blotting.

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    Bucladesine hemicalcium purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:932:175231. [Abstract]

    Customer Validation
     B16F10 cells was pretreated or not with 3 μM Bucladesine sodium for 1 h before pterostilbene was applied for 24 h, 48h or 72 h at 3 μM. The CREB and p-CREB protein expression levels were detected by WB.

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    Bucladesine hemicalcium purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:932:175231. [Abstract]

    Customer Validation
     Cell viability of H295R cells exposed to 0–40 μM BHPF in the presence of 100 μM dbcAMP for 48 h.

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    Bucladesine hemicalcium purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2022 Oct 15:932:175231. [Abstract]

    Customer Validation
     Micrographs presenting the incorporation of EdU in H295R cells exposed to BHPF or combined with 100 μM dbcAMP for 48 h. Red: the EdU positive cells; blue: the cell nuclei (Hoechst).

  • Bucladesine hemicalcium