1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. RAD51

RAD51

RAD51 protein family assist in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA and yeast Rad51. In humans, RAD51 is a 339-amino acid protein that plays a major role in homologous recombination of DNA during double strand break repair. RAD51 is involved in the search for homology and strand pairing stages of the process. RAD51 can interact with the ssDNA-binding protein RPA, BRCA2, PALB2 and RAD52. Recent studies using fluorescent labeled Rad5 has indicated that Rad51 fragments elongate via multiple nucleation events followed by growth, with the total fragment terminating when it reaches about 2 μm in length.

RAD51 Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-13202
    T0070907 Inhibitor 99.98%
    T0070907 is a potent PPARγ antagonist with a Ki of 1 nM.
  • HY-19793
    RS-1 Activator 99.55%
    RS-1 is a RAD51 activator, and also increases CRISPR/Cas9-mediated knock-in efficiencies.
  • HY-101462
    RAD51 Inhibitor B02 Inhibitor 99.87%
    RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.
  • HY-10206
    Amuvatinib Inhibitor 99.36%
    Amuvatinib (MP470) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib (MP470) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair. Antineoplastic activity.
  • HY-103710
    IBR2 Inhibitor 98.14%
    IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis.
  • HY-126972A
    RI(dl)-2 TFA Inhibitor
    RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM).
  • HY-15317
    RI-1 Inhibitor 99.83%
    RI-1 is a RAD51 inhibitor, with IC50s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells.
  • HY-16904
    RI-2 Inhibitor 99.22%
    RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells.
Isoform Specific Products

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