2. Cell Cycle/DNA Damage
  3. RAD51
  4. RI(dl)-2 TFA

RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM).

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RI(dl)-2 TFA Chemical Structure

RI(dl)-2 TFA Chemical Structure

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Solution
10 mM * 1 mL in DMSO USD 275 In-stock
Solid
1 mg USD 85 In-stock
5 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

RI(dl)-2 TFA Related Antibodies

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Description

RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM)[1].

IC50 & Target

IC50: 11.1 μM (RAD51-mediated D-loop formation)[1]
In Vitro

RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, which are incapable of D-loop activity and simultaneously shielded from related (e.g., RAD52-mediated) pathways that promote single-strand annealing (SSA)[1].
RI(dl)-2 does not modulate the affinity of RAD51 to ssDNA or the stability of preformed RAD51-ssDNA complexes when challenged with high concentrations of salt[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RI(dl)-2 TFA Related Antibodies
Molecular Weight

435.59

Formula

C19H17N3.(1.3)C2HF3O2
Appearance

Solid

Color

Purple to purplish red

SMILES

CCNC1=CC=C(C2=NC3=C(N4C2=CC=C4)C=CC=C3)C=C1.OC(C(F)(F)F)=O.[1.3]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 98.02%

COA (246 KB) LCMS (100 KB)

Handling Instructions (2659 KB)
References
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RI(dl)-2 TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RI(dl)-2RAD51D-loopssDNAhomologousrecombinationsingle-strandannealingInhibitorinhibitorinhibit

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