1. Cell Cycle/DNA Damage
  2. RAD51
  3. RI(dl)-2 TFA

RI(dl)-2 TFA 

Cat. No.: HY-126972A Purity: ≥98.0%
Handling Instructions

RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM).

For research use only. We do not sell to patients.

RI(dl)-2 TFA Chemical Structure

RI(dl)-2 TFA Chemical Structure

Size Price Stock
Solution
10 mM * 1 mL in DMSO USD 605 Ask For Quote & Lead Time
Solid
5 mg USD 550 Ask For Quote & Lead Time

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Description

RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM)[1].

IC50 & Target

IC50: 11.1 μM (RAD51-mediated D-loop formation)[1]

In Vitro

RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, which are incapable of D-loop activity and simultaneously shielded from related (e.g., RAD52-mediated) pathways that promote single-strand annealing (SSA)[1].
RI(dl)-2 does not modulate the affinity of RAD51 to ssDNA or the stability of preformed RAD51-ssDNA complexes when challenged with high concentrations of salt[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

435.59

Formula

C19H17N3.(1.3)C2HF3O2

SMILES

CCNC1=CC=C(C2=NC3=C(N4C2=CC=C4)C=CC=C3)C=C1.OC(C(F)(F)F)=O.[1.3]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References

Purity: ≥98.0%

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RI(dl)-2 TFA
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HY-126972A
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