2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Liposome

Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

Liposome Related Products (155):

Cat. No. Product Name Effect Purity
  • HY-112251
    D-Lin-MC3-DMA
    		≥98.0%
    D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
  • HY-138170
    ALC-0315
    		≥98.0%
    ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
  • HY-134541
    SM-102
    		≥98.0%
    SM-102 is an ionizable amino lipid that can be used for the formation of lipid nanoparticles (LNPs). SM-102 has the potential for development of lipid nanoparticles for delivery of mRNA-based vaccines.
  • HY-N0322
    Cholesterol
    		98.53%
    Cholesterol is the major sterol in mammals and is makes up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.
  • HY-112754A
    DOTAP chloride
    		≥98.0%
    DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid.
  • HY-46759
    Genevant CL1
    		≥98.0%
    Genevant CL1 is a lipid that can be used for mRNA lipid nanoparticle (LNP) vaccine delivery.
  • HY-151507
    306Oi10
    306Oi10 is a branched-chain ionizable lipidoid that can be used for constructing lipid nanoparticles (LNPs) for the delivery of messenger RNA.
  • HY-141892A
    DSPE-PEG Carboxylic acid sodium (MW 2000)
    DSPE-PEG Carboxylic acid sodium (MW 2000) is a PEG-lipid that can be used to form micelles as nanoparticles for drug delivery. DSPE-PEG Carboxylic acid sodium (MW 2000) increases the blood circulation time of liposomes.
  • HY-138300
    ALC-0159
    		≥98.0%
    ALC-0159, a polyethylene glycol (PEG) lipid conjugate, could be used as vaccine excipient.
  • HY-112758
    DLin-KC2-DMA
    		≥98.0%
    DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies.
  • HY-112764
    DMG-PEG 2000
    		≥98.0%
    DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
  • HY-112005
    DOPE
    		≥98.0%
    DOPE (dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA.
  • HY-145405
    C12-200
    		≥98.0%
    C12-200 is a benchmark ionizable cationic lipidoid along with helper lipids. C12-200 is commonly used for mRNA delivery.
  • HY-112757
    DLinDMA
    		98.12%
    DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery.
  • HY-125853
    Phosphatidylcholines,soya
    		98.20%
    Phosphatidylcholines,soya is a phosphatidylcholine from soybean used in the preparation of liposomes. Phosphatidylcholines,soya can be used as a vehicle in animal drug administration.
  • HY-N0322A
    Cholesterol (Water Soluble)
    Cholesterol Water Soluble can be used for the research of the effects of cholesterol on the potassium currents in inner hair cells (IHCs). Cholesterol is an integral component of the cell membrane and regulates the activity of ion channels in the lipid bilayer.
  • HY-W040193
    1,2-Distearoyl-sn-glycero-3-phosphorylcholine
    		≥98.0%
    1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
  • HY-113424A
    1,2-Dioleoyl-sn-glycero-3-phosphocholine
    		≥98.0%
    1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) is a phospholipid and is commonly used alone, or with other components, in the generation of micelles, liposomes, and other types of artificial membranes.
  • HY-130751
    DODAP
    		≥98.0%
    DODAP is a cationic lipid. The ionizable lipid DODAP is a lipid component of the liposome. DODAP can be used to encapsulate siRNA, immunostimulatory chemotherapeutic agents for in vitro and in vivo delivery and so on.
  • HY-125924
    DSPE-PEG(2000)-Amine
    		≥98.0%
    DSPE-PEG(2000)-Amine, an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.