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  3. 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (Synonyms: DOPE)

Cat. No.: HY-112005
Handling Instructions

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA.

For research use only. We do not sell to patients.

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Chemical Structure

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Chemical Structure

CAS No. : 4004-05-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
100 mg USD 120 In-stock
Estimated Time of Arrival: December 31
250 mg USD 245 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA[1].

IC50 & Target

IC50: helper lipid for liposome[1]

In Vitro

In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent)[1].
With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity[1].
LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells[1].
LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs[1].

Molecular Weight

744.03

Formula

C₄₁H₇₈NO₈P

CAS No.

4004-05-1

SMILES

O=P(OC[[email protected]](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (336.01 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3440 mL 6.7202 mL 13.4403 mL
5 mM 0.2688 mL 1.3440 mL 2.6881 mL
10 mM 0.1344 mL 0.6720 mL 1.3440 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamineDOPEOthersPEemulsifiertransfectionDNAliposomecationicsiRNAphospholipidknock-downInhibitorinhibitorinhibit

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Product name:
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
Cat. No.:
HY-112005
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