1. Oligonucleotides
  2. Phospholipids
  3. DOPE

DOPE (Synonyms: dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine)

Cat. No.: HY-112005 Purity: ≥98.0%
Handling Instructions

DOPE (dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA.

For research use only. We do not sell to patients.

DOPE Chemical Structure

DOPE Chemical Structure

CAS No. : 4004-05-1

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Based on 1 publication(s) in Google Scholar

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Description

DOPE (dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA[1].

IC50 & Target

IC50: helper lipid for liposome[1]

In Vitro

In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent)[1].
With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity[1].
LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells[1].
LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

744.03

Formula

C41H78NO8P

CAS No.
SMILES

O=P(OC[[email protected]](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 40 mg/mL (53.76 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3440 mL 6.7202 mL 13.4403 mL
5 mM 0.2688 mL 1.3440 mL 2.6881 mL
10 mM 0.1344 mL 0.6720 mL 1.3440 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (2.69 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: 2 mg/mL (2.69 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2 mg/mL (2.69 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: ≥98.0%

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DOPE
Cat. No.:
HY-112005
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