INSR/CD220
The insulin receptor (CD220) is a disulfide-linked heterotetramer of two extracellular alpha subunits and two transmembrane beta subunits with intrinsic tyrosine kinase activity. Ligand binding to the alpha subunits triggers autophosphorylation of the beta subunits and recruitment of IRS and Shc adaptors, launching the PI3K-AKT metabolic arm and the MAPK mitogenic arm. Alternative splicing at exon 11 generates an A isoform predominant in fetal and cancer cells and a B isoform of mature metabolic tissues. Loss-of-function mutations cause severe insulin resistance syndromes, the receptor is downregulated in type 2 diabetes, and anti-insulin receptor antibodies can produce both hypoglycemia and extreme resistance.
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INSR/CD220 Recombinant Proteins (7)
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Inhibitors & Agonists (205)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
