IL-5 Receptor
IL-5 receptor (IL-5R) belongs to the type I cytokine receptor family and is a heterodimer consisting of two polypeptide chains, an α subunit that binds IL-5 and confers specificity to the receptor cytokine, and a β subunit that contains the signal transduction domain. Among them, the IL-5Rα chain is expressed only by eosinophils, some basophils and murine B1 cells or B-cell precursors. The β chain does not bind IL-5, is not specific for this cytokine, and is expressed on almost all leukocytes. At the same time, the β-chain of the IL-5 receptor is also utilized by the IL-3 and GM-CSF receptors, hence the term βc or common β-chain. When IL-5R binds to its ligand IL-5, it activates a series of signal transduction cascades that stimulate the induction of rapid tyrosine phosphorylation of cellular proteins, including βc, SH2/SH3-containing proteins such as Vav and Shc, Btk and Btk-related molecules, JAK1/JAK2 and STAT1/STAT5, PI3K, and activation of downstream MAP kinase signaling molecules. For example, IL-5 binding to mouse B cells and IL-5R on mouse and human eosinophils activates JAK1/2 and STAT1/5. The Ras extracellular signal-regulated kinase (ERK) pathway is also associated with IL-5 signaling to maintain cell survival, proliferation, and differentiation of eosinophils[1][2].
- [1]. Takatsu K, et al. Interleukin-5 and IL-5 receptor in health and diseases. Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(8):463-85. [Content Brief]
- [2]. N Geijsen, et al. Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family. Cytokine Growth Factor Rev. 2001 Mar;12(1):19-25. [Content Brief]
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IL-5 Receptor Recombinant Proteins (7)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
