1. Signaling Pathways
  2. Immunology/Inflammation
  3. Nuclear Factor of activated T Cells (NFAT)

Nuclear Factor of activated T Cells (NFAT)

Nuclear factor of activated T cells (NFAT) proteins are a family of Ca2+/calcineurin-dependent transcription factors that were initially identified as inducible nuclear factors that could bind the interleukin-2 (IL-2) promoter in activated T cells. However, when all of the proteins of the NFAT family had been isolated and molecularly characterized, it became clear that their expression was not limited to T cells. Recent work has uncovered new regulatory roles for NFAT proteins in diverse organs, including the central nervous system, blood vessels, heart, kidney, bone, skeletal muscle and haematopoietic stem cells. For examples, cells in the vessel wall display a diverse array of Ca2+ signaling modalities, which are subject to change during disease. The fact that NFAT proteins are able to decode and translate these signals into changes in gene expression makes them potential regulators of vascular pathogenesis.

Nuclear Factor of activated T Cells (NFAT) Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-117987
    CPS-11
    Activator
    CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines.
  • HY-147369
    NFATc1-IN-1
    Inhibitor
    NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC50 of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research.