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11R-VIVIT 

Cat. No.: HY-P1430
Handling Instructions

11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

11R-VIVIT Chemical Structure

11R-VIVIT Chemical Structure

CAS No. : 592517-80-1

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Description

11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy[1].

IC50 & Target

NFAT[1]

In Vitro

11R-VIVIT (100 nM) shows a significant reduction of NFAT2 expression in high glucose treated podocytes compared to podocytes treated with normal glucose. 11R-VIVIT attenuates high glucose induced filtration barrier dysfunction of podocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

11R-VIVIT significantly abrogates the increased urinary albumin excretion rates, attenuates glomerular basement membrane (GBM) thickening and podocyte foot process effacement, partially restores podocyte number, inhibits NFAT2 activation and uPAR expression in glomerular podocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

3573.15

Formula

C₁₄₇H₂₅₉N₆₇O₃₆S

CAS No.
Sequence Shortening

RRRRRRRRRRRGGGMAGPHPVIVITGPHEE

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
11R-VIVIT
Cat. No.:
HY-P1430
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