11R-VIVIT
Based on 9 publication(s) in Google Scholar
11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.61%
- No. CAS: 592517-80-1
- Fòrmula: C147H259N67O36S
- Peso molecular:3573.15
-
Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 11R-VIVIT
More- Cell Rep Med. 2025 Feb 18;6(2):101922. [Abstract]
- Acta Pharmacol Sin. 2022 Aug;43(8):2081-2093. [Abstract]
- CNS Neurosci Ther. 2025 Feb;31(2):e70222. [Abstract]
- Inflammopharmacology. 2023 Oct;31(5):2431-2443. [Abstract]
- Int J Mol Sci. 2026 Jun 22;27(12):5635. [Abstract]
- Am J Respir Cell Mol Biol. 2023 Mar;68(3):256-266. [Abstract]
- Elife. 2022 Aug 22;11:e79957. [Abstract]
- bioRxiv. May 18, 2022.
- Research Square Preprint. 2021 Oct.
Actividad biológica
Descripciòn
IC50 & Target
NFAT[1]
In Vitro
11R-VIVIT (100 nM) shows a significant reduction of NFAT2 expression in high glucose treated podocytes compared to podocytes treated with normal glucose. 11R-VIVIT attenuates high glucose induced filtration barrier dysfunction of podocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 592517-80-1
-
Appearance Solid
-
Peso molecular 3573.15
-
Fòrmula C147H259N67O36S
-
Color White to off-white
-
Synonyms
Cell permeable NFAT inhibitor
-
Sequence Shortening
RRRRRRRRRRRGGGMAGPHPVIVITGPHEE
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (9)
-
Journal Impact Factor
-
Most Recent
-
Cell Rep Med
MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1. [Abstract]2025 Feb 18;6(2):101922. PMID: 39842432 -
Acta Pharmacol Sin
NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury. [Abstract]2022 Aug;43(8):2081-2093. PMID: 34937917 -
CNS Neurosci Ther
NFAT1 Signaling Contributes to Bone Cancer Pain by Regulating IL-18 Expression in Spinal Microglia. [Abstract]2025 Feb;31(2):e70222. PMID: 39957627 -
Inflammopharmacology
2023 Oct;31(5):2431-2443. PMID: 37450074 -
Int J Mol Sci
Activated Macrophages Promote TNF-α-Associated Tumor Cell Necroptosis in Pituitary Apoplexy Through the PIEZO1-NFATC2/REL Axis. [Abstract]2026 Jun 22;27(12):5635. PMID: 42353349 -
Am J Respir Cell Mol Biol
Neuromedin U Induces Pulmonary ILC2 Activation via the NMUR1 Pathway During Acute RSV Infection. [Abstract]2023 Mar;68(3):256-266. PMID: 36227802 -
Elife
2022 Aug 22;11:e79957. PMID: 35993548 -
-
Solvente y solubilidad
In Vitro:
H2O : ≥ 50 mg/mL (13.99 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (269 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.2799 mL | 1.3993 mL | 2.7987 mL | 6.9966 mL |
| 5 mM | 0.0560 mL | 0.2799 mL | 0.5597 mL | 1.3993 mL | |
| 10 mM | 0.0280 mL | 0.1399 mL | 0.2799 mL | 0.6997 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
11R-VIVIT Related Classifications
HY-P1430 Related Classifications
Powered by Bioz