2. Immunology/Inflammation
  3. Nuclear Factor of activated T Cells (NFAT)
  4. 11R-VIVIT

11R-VIVIT  (Synonyms: Cell permeable NFAT inhibitor)

Cat. No.: HY-P1430
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11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

11R-VIVIT Chemical Structure

11R-VIVIT Chemical Structure

CAS No. : 592517-80-1

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11R-VIVIT Related Antibodies

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Description

11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy[1].

IC50 & Target

NFAT[1]
In Vitro

11R-VIVIT (100 nM) shows a significant reduction of NFAT2 expression in high glucose treated podocytes compared to podocytes treated with normal glucose. 11R-VIVIT attenuates high glucose induced filtration barrier dysfunction of podocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

11R-VIVIT Related Antibodies
In Vivo

11R-VIVIT significantly abrogates the increased urinary albumin excretion rates, attenuates glomerular basement membrane (GBM) thickening and podocyte foot process effacement, partially restores podocyte number, inhibits NFAT2 activation and uPAR expression in glomerular podocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

3573.15

Formula

C147H259N67O36S
CAS No.
Sequence Shortening

RRRRRRRRRRRGGGMAGPHPVIVITGPHEE
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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11R-VIVIT Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

11R-VIVIT592517-80-1Cell permeable NFAT inhibitorNuclear Factor of activated T Cells (NFAT)cell-permeablenuclearactivatedglucosefiltrationbarrierdysfunctionpodocytesInhibitorinhibitorinhibit

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