Salt Form-Free Base Dose Conversion Calculator

If the effective dose (mg/kg) referenced in your animal study is based on the free base, you will need to convert it to the salt-form dose for administration:

Actual Dose Administered (mg/kg) = Target Free Base Dose (mg/kg) × (MWSalt Form ÷ MWFree Base)
error

Actual Dose Administered Actual Dose Administered
=
Target Free Base Dose * Target Free Base Dose *
×
MWSalt Form * MWSalt Form *
g/mol
÷
MWFree Base * MWFree Base *
g/mol
An example of how to use the Salt Form-Free Base Dose Conversion Calculator:

The effective free-base dose of SKF-96365 in an animal study is 10 mg/kg. You need to administer SKF-96365 hydrochloride instead.

  1. Enter 10 in the Target Free Base Dose field (mg/kg).
  2. Enter the molecular weight of the salt form, e.g. MWSalt Form = 402.91.
  3. Enter the molecular weight of the free base, e.g. MWFree Base = 366.45.
  4. Click Calculate.
  5. The Actual Dose Administered is approximately 11.0 mg/kg.