1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. Melatonin Receptor

Melatonin Receptor

Melatonin Receptor is a G protein-coupled receptor (GPCR) which binds melatonin. Three types of melatonin receptor have been cloned. The MT1 and MT2 receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 has been identified in amphibia and birds. The MT1 subtype's expression in the pars tuberalis of the pituitary gland and suprachiamatic nuclei of the hypothalamus is indicative of melatonin's circadian and reproductive functional involvement. The MT2 subtype's expression in the retina is suggestive of melatonin's effect on the mammalian retina occurring through this receptor. Research suggests that melatonin acts to inhibit the Ca2+-dependent release of dopamine. Melatonin's action in the retina is believed to affect several light-dependent functions, including phagocytosis and photopigment disc shedding.

Melatonin Receptor Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-B0075
    Melatonin Activator 98.95%
    Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties.
  • HY-A0014
    Ramelteon Agonist 99.92%
    Ramelteon is a highly potent and selective melatonin receptor agonist with Ki values of 14 and 112 pM for human melatonin1 and melatonin2.
  • HY-14803
    Tasimelteon Agonist 99.58%
    Tasimelteon is a melatonin MT1 and MT2 receptor agonist.
  • HY-103005
    Ramelteon metabolite M-II Activator
    Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist.
Isoform Specific Products

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