1. GPCR/G Protein
    Neuronal Signaling
  2. Melatonin Receptor

Melatonin Receptor

Melatonin Receptor is a G protein-coupled receptor (GPCR) which binds melatonin. Three types of melatonin receptor have been cloned. The MT1 and MT2 receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 has been identified in amphibia and birds. The MT1 subtype's expression in the pars tuberalis of the pituitary gland and suprachiamatic nuclei of the hypothalamus is indicative of melatonin's circadian and reproductive functional involvement. The MT2 subtype's expression in the retina is suggestive of melatonin's effect on the mammalian retina occurring through this receptor. Research suggests that melatonin acts to inhibit the Ca2+-dependent release of dopamine. Melatonin's action in the retina is believed to affect several light-dependent functions, including phagocytosis and photopigment disc shedding.

Melatonin Receptor Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-A0014
    Ramelteon Agonist
    Ramelteon (TAK-375; Rozerem)is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 (plusmn) 8.55 pM) and MT2 (20.1 (plusmn) 9.25 pM) receptors and selectivity over the MT3 receptor.
  • HY-B0075
    Melatonin Activator
    Melatonin, a hormone produced in the brain, is a potent melatonin receptor activator, and possesses important antioxidative and anti-inflammatory properties.
  • HY-14803
    Tasimelteon Agonist
    Tasimelteon is a melatonin MT1 and MT2 receptor agonist.