1. GPCR/G Protein
    Neuronal Signaling
  2. Melatonin Receptor
  3. S26131

S26131 

Cat. No.: HY-122136 Purity: 99.30%
Handling Instructions

S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. S26131 behaves as an MT1 and MT2 antagonist.

For research use only. We do not sell to patients.

S26131 Chemical Structure

S26131 Chemical Structure

CAS No. : 296280-56-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 245 In-stock
Estimated Time of Arrival: December 31
50 mg USD 445 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. S26131 behaves as an MT1 and MT2 antagonist[1].

In Vitro

S26131 behaves as an antagonist on MT1 and MT2 receptors with KB values of 5.32 and 143 nM, respectively[1].

Molecular Weight

498.61

Formula

C₃₁H₃₄N₂O₄

CAS No.

296280-56-3

SMILES

CC(NCCC1=C2C=C(C=CC2=CC=C1)OCCCOC3=CC=C4C=CC=C(C4=C3)CCNC(C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0056 mL 10.0279 mL 20.0558 mL
5 mM 0.4011 mL 2.0056 mL 4.0112 mL
10 mM 0.2006 mL 1.0028 mL 2.0056 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

S26131S 26131S-26131Melatonin ReceptormelatoninergicligandMT2selectivelyantagonistInhibitorinhibitorinhibit

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S26131
Cat. No.:
HY-122136
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