Signaling Pathway

DNA/RNA Synthesis

DNA/RNA Synthesis

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DNA/RNA Synthesis Inhibitors & Modulators (29)

Product Name Catalog No. Brief Description
Acelarin

HY-100885

Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine.

alpha-Amanitin

HY-19610

alpha-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II.

Beaucage reagent

HY-100951

Beaucage reagent is found to be potent in causing DNA cleavage.

Bleomycin sulfate

HY-17565

Bleomycin (Blenoxane) is a glycopeptide antibiotic; used as an anticancer agent; Bleomycin acts by induction of DNA strand breaks.

BMH-21

HY-12484

BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription; does not cause phosphorylation of H2AX.

BRD7116

HY-18714

BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity.

Capecitabine

HY-B0016

Capecitabine is an anti-cancer chemotherapy drug.

Chebulinic acid

HY-N2033

Chebulinic acid is a potent natural inhibitor of M.

COH29

HY-19931

COH29 is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity with IC50 value of 8 μM in KB cell.

CX-5461

HY-13323

CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.

Cycloheximide

HY-12320

Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM.

Gemcitabine

HY-17026

Gemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.

Gemcitabine Hydrochloride

HY-B0003

GemcitabineHcl (LY 188011 Hcl) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.

Guanine

HY-Y1055

Guanine is one of the fundamental components of nucleic acids (DNARNA).

Hydroxyurea

HY-B0313

Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

L189

HY-15588

L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM.

L67

HY-15586

L67 is a novel, competitive human DNA ligase inhibitor, inhibits DNA ligases I and III with IC50 of 10 μM and 10 μM.

LMI070

HY-19620

LMI070 (NVS-SM1) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.

ML216

HY-12342

ML216(CID-49852229) is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively.

Nedaplatin

HY-13700

Nedaplatin is a derivative of cisplatin and DNA damage agent.