Cat. No.: HY-104077

Remdesivir

(Synonyms: GS-5734)

223 Cited Publications

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Based on 223 publication(s) in Google Scholar

Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection.

For research use only. We do not sell to patients.

Purity: 99.95%
CAS No.: 1809249-37-3
Formula: C₂₇H₃₅N₆O₈P
Molecular Weight:602.58

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Remdesivir Chemical Structure

CAS No.: 1809249-37-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (223)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

EC₅₀: 30 nM (murine hepatitis virus, delayed brain tumor cell), 74 nM (SARS-CoV, HAE cell), 74 nM (MERS-CoV, HAE cell)^[1]
EC₅₀: 3.3 μM (SARS-CoV-2), 4.7 μM (SARS-CoV-2 alpha), 32 μM (SARS-CoV-2 beta), 3.7 μM (SARS-CoV-2 gamma) and 9.2 μM (SARS-CoV-2 delta)^[3]

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
16HBE14o-	CC₅₀	41 μM Compound: Remdesivir	Cytotoxicity against human 16HBE14o- after 72 hrs by MTT assay Cytotoxicity against human 16HBE14o- after 72 hrs by MTT assay	[PMID: 34408808]
A549	CC₅₀	43 μM Compound: Remdesivir	Cytotoxicity against human A549 cells overexpressing ACE2 and TMPRSS2 incubated for 48 hrs by MTS assay Cytotoxicity against human A549 cells overexpressing ACE2 and TMPRSS2 incubated for 48 hrs by MTS assay	[PMID: 36097498]
Caco-2	CC₅₀	80 μM Compound: Remdesivir	Cytotoxicity against human Caco2 cells infected with SARS-COV-2 assessed as reduction in cell viability by celltiter-glo luminescent cell viability assay Cytotoxicity against human Caco2 cells infected with SARS-COV-2 assessed as reduction in cell viability by celltiter-glo luminescent cell viability assay	[PMID: 34273661]
Caco-2	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability	[PMID: 38432056]
Caco-2	CC₅₀	2584.38 μM Compound: REMDESIVIR	Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay	10.21203/rs.3.rs-23951/v1
Caco-2	IC₅₀	0.76 μM Compound: REMDESIVIR	Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging	10.21203/rs.3.rs-23951/v1
Calu-3	CC₅₀	97 μM Compound: Remdesivir	Cytotoxicity against human Calu-3 cells infected with SARS-COV-2 by celltiter-glo luminescent cell viability assay Cytotoxicity against human Calu-3 cells infected with SARS-COV-2 by celltiter-glo luminescent cell viability assay	[PMID: 34273661]
Calu-3	CC₅₀	>50 μM Compound: RDV	Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability after 48 hrs by Cell-Tox green based fluorescence assay Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability after 48 hrs by Cell-Tox green based fluorescence assay	[PMID: 34583312]
Calu-3	CC₅₀	>5 μM Compound: Remdesivir	Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability	[PMID: 35290044]
Calu-3	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
Calu-3	CC₅₀	>0.1 μM Compound: 1	Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability	[PMID: 36651644]
Calu-3	CC₅₀	>10 μM Compound: Remdesivir	Cytotoxicity against human Calu-3 cells infected with SARS CoV-2 USA-WA1/2020 clinical isolate assessed as reduction in cell viability incubated for 48 hrs by imaging analysis Cytotoxicity against human Calu-3 cells infected with SARS CoV-2 USA-WA1/2020 clinical isolate assessed as reduction in cell viability incubated for 48 hrs by imaging analysis	[PMID: 37482021]
Calu-3	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against human Calu-3 cells measured after 2 days by MTT assay Cytotoxicity against human Calu-3 cells measured after 2 days by MTT assay	[PMID: 37633203]
Calu-3	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability	[PMID: 38432056]
CCRF-CEM	CC₅₀	11.2 μM Compound: Remdesivir	Cytotoxicity against human CEM cells assessed as reduction in cell viability Cytotoxicity against human CEM cells assessed as reduction in cell viability	[PMID: 38432056]
HCT-8	CC₅₀	53.18 μM Compound: Remdesivir	Cytotoxicity against human HCT-8 cells assessed as redcution in cell viability incubated for 96 hrs by PrestoBlue reagent based assay Cytotoxicity against human HCT-8 cells assessed as redcution in cell viability incubated for 96 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
HEK-293T	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay	[PMID: 34147744]
HEL 299	CC₅₀	>10 μM Compound: Remdesivir	Cytotoxicity against human HEL 299 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter96 Aqueous One Solution cell proliferation assay Cytotoxicity against human HEL 299 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter96 Aqueous One Solution cell proliferation assay	[PMID: 37252100]
HeLa	CC₅₀	>20 μM Compound: 3; GS-5734	Cytotoxicity against human HeLa after 4 to 5 days by Cell-Titer Glo viability assay Cytotoxicity against human HeLa after 4 to 5 days by Cell-Titer Glo viability assay	[PMID: 28792763]
HeLa	EC₅₀	0.14 μM Compound: 3; GS-5734	Antiviral activity against Ebolavirus infected in human HeLa cells after 48 hrs by immuno-staining assay Antiviral activity against Ebolavirus infected in human HeLa cells after 48 hrs by immuno-staining assay	[PMID: 28792763]
HEp-2	IC₅₀	0.11 μM Compound: 1; GS-5734	Drug metabolism in human HEp-2 cells assessed as 1-NTP metabolite concentration at EC50 over 48 hrs by LC-MS/MS analysis Drug metabolism in human HEp-2 cells assessed as 1-NTP metabolite concentration at EC50 over 48 hrs by LC-MS/MS analysis	[PMID: 33835812]
Hepatocyte	CC₅₀	2.5 μM Compound: 1; RDV	Cytotoxicity against human primary hepatocytes assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against human primary hepatocytes assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
HepG2	CC₅₀	52.62 μM Compound: Remdesivir	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
HepG2	CC₅₀	11.1 μM Compound: 1; RDV	Cytotoxicity against human HepG2 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against human HepG2 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
Huh-7	CC₅₀	>20 μM Compound: 3; GS-5734	Cytotoxicity against human HuH7 after 4 to 5 days by Cell-Titer Glo viability assay Cytotoxicity against human HuH7 after 4 to 5 days by Cell-Titer Glo viability assay	[PMID: 28792763]
Huh-7	CC₅₀	>10 μM Compound: GS-5734; 8b	Cytotoxicity against human Huh-7 cells by celltiter-glo Assay Cytotoxicity against human Huh-7 cells by celltiter-glo Assay	[PMID: 32563812]
Huh-7	CC₅₀	>10 μM Compound: RDV; GS-5734	Cytotoxicity against human Huh-7 cells by CellTiter-Glo assay Cytotoxicity against human Huh-7 cells by CellTiter-Glo assay	[PMID: 32845145]
Huh-7	CC₅₀	>10 μM Compound: RDV; GS-5734	Cytotoxicity against human Huh7 cells incubated for 6 days by cellTiter-Glo assay Cytotoxicity against human Huh7 cells incubated for 6 days by cellTiter-Glo assay	[PMID: 32845145]
Huh-7	CC₅₀	10.37 μM Compound: Remdesivir	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 24 hrs by Celltiter-glo luminescent cell viability assay Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 24 hrs by Celltiter-glo luminescent cell viability assay	[PMID: 34242027]
Huh-7	CC₅₀	77 μM Compound: Remdesivir	Cytotoxicity against human Huh-7 cells infected with SARS-COV-2 assessed as reduction in cell viability by celltiter-glo luminescent cell viability assay Cytotoxicity against human Huh-7 cells infected with SARS-COV-2 assessed as reduction in cell viability by celltiter-glo luminescent cell viability assay	[PMID: 34273661]
Huh-7	CC₅₀	>50 μM Compound: RDV	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo analysis Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo analysis	[PMID: 34583312]
Huh-7	CC₅₀	>10 μM Compound: Remdesivir	Cytotoxicity against human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter96 Aqueous One Solution cell proliferation assay Cytotoxicity against human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter96 Aqueous One Solution cell proliferation assay	[PMID: 37252100]
Huh-7	CC₅₀	1.4 μM Compound: Remdesivir	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability	[PMID: 38432056]
Huh-7	CC₅₀	90 μM Compound: Remdesivir	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 39028935]
Macrophage	CC₅₀	>20 μM Compound: 3; GS-5734	Cytotoxicity against human primary macrophages after 4 to 5 days by Cell-Titer Glo viability assay Cytotoxicity against human primary macrophages after 4 to 5 days by Cell-Titer Glo viability assay	[PMID: 28792763]
MRC5	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by Celltiter-glo luminescent cell viability assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by Celltiter-glo luminescent cell viability assay	[PMID: 34242027]
MRC5	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
MT4	CC₅₀	1.7 μM Compound: 1; RDV	Cytotoxicity against human MT4 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against human MT4 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
PBMC	CC₅₀	>20 μM Compound: 1; RDV	Cytotoxicity against quiescent human PBMC cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against quiescent human PBMC cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
PBMC	CC₅₀	14.8 μM Compound: 1; RDV	Cytotoxicity against stimulated human PBMC cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against stimulated human PBMC cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
PBMC	CC₅₀	2 μM Compound: Remdesivir	Cytotoxicity against human PBMC cells assessed as inhibition of cell proliferation incubated for 2 to 4 days by CellTiter 96 non-radioactive cell proliferation assay Cytotoxicity against human PBMC cells assessed as inhibition of cell proliferation incubated for 2 to 4 days by CellTiter 96 non-radioactive cell proliferation assay	[PMID: 38242544]
PBMC	CC₅₀	4.9 μM Compound: Remdesivir	Cytotoxicity against human PBMC cells assessed as reduction in cell viability Cytotoxicity against human PBMC cells assessed as reduction in cell viability	[PMID: 38432056]
PC-3	CC₅₀	1.4 μM Compound: 1; RDV	Cytotoxicity against human PC-3 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against human PC-3 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
Vero	CC₅₀	>25 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero cells infected with SARS-CoV-2 betaCoV/KOR/KCDC03/2020 assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay Cytotoxicity against African green monkey Vero cells infected with SARS-CoV-2 betaCoV/KOR/KCDC03/2020 assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay	[PMID: 33160024]
Vero	CC₅₀	>40 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth by coulter counter analysis Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth by coulter counter analysis	[PMID: 33479570]
Vero	CC₅₀	>40 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by coulter counter method Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by coulter counter method	[PMID: 34571172]
Vero	EC₅₀	0.61 μM Compound: Remdesivir	Antiviral activity against Severe acute respiratory syndrome coronavirus 2 UC-1075 infected in African green monkey Vero cells assessed as reduction in plaque formation measured after 5 days by microscopic analysis Antiviral activity against Severe acute respiratory syndrome coronavirus 2 UC-1075 infected in African green monkey Vero cells assessed as reduction in plaque formation measured after 5 days by microscopic analysis	[PMID: 34571172]
Vero	CC₅₀	70.6 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth by Coulter counter analysis Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth by Coulter counter analysis	[PMID: 36332548]
Vero	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
Vero	CC₅₀	>100 μM Compound: RDV	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 36764470]
Vero	CC₅₀	>25 μM Compound: Remdesivir	Cytotoxicity against african green monkey Vero cells Cytotoxicity against african green monkey Vero cells	[PMID: 36870624]
Vero	CC₅₀	>10 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero cells incubated for 5 days by neutral red uptake assay Cytotoxicity against African green monkey Vero cells incubated for 5 days by neutral red uptake assay	[PMID: 37482021]
Vero	CC₅₀	>40 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth by coulter counter method Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth by coulter counter method	[PMID: 38232463]
Vero	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell proliferation incubated for 2 to 4 days by CellTiter 96 non-radioactive cell proliferation assay Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell proliferation incubated for 2 to 4 days by CellTiter 96 non-radioactive cell proliferation assay	[PMID: 38242544]
Vero	EC₅₀	2.3 μM Compound: Remdesivir	Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in african green monkey Vero cells assessed as reduction in viral replication by qRT-PCR analysis Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in african green monkey Vero cells assessed as reduction in viral replication by qRT-PCR analysis	[PMID: 38242544]
Vero	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability	[PMID: 38432056]
Vero	CC₅₀	>25 μM Compound: Remdesivir	Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr	10.1101/2020.03.20.999730
Vero	IC₅₀	11.41 μM Compound: Remdesivir	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr	10.1101/2020.03.20.999730
Vero C1008	EC₅₀	0.62 μM Compound: Remdesivir	Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs	[PMID: 32511357]
Vero C1008	CC₅₀	>100 μM Compound: GS-5734; 8b	Cytotoxicity against African green monkey Vero E6 cells Cytotoxicity against African green monkey Vero E6 cells	[PMID: 32563812]
Vero C1008	CC₅₀	100 μM Compound: RDV; GS-5734	Cytotoxicity against African green monkey Vero E6 cells by the CCK8 assay Cytotoxicity against African green monkey Vero E6 cells by the CCK8 assay	[PMID: 32845145]
Vero C1008	EC₅₀	0.069 μM Compound: 52	Antiviral activity against SARS-CoV infected in Vero E6 cells assessed as reduction in viral replication measured after 48 hrs by qRT-PCR assay Antiviral activity against SARS-CoV infected in Vero E6 cells assessed as reduction in viral replication measured after 48 hrs by qRT-PCR assay	[PMID: 33486200]
Vero C1008	EC₅₀	0.074 μM Compound: 52	Antiviral activity against MERS-CoV infected in Vero E6 cells assessed as reduction in viral replication measured after 48 hrs by qRT-PCR assay Antiviral activity against MERS-CoV infected in Vero E6 cells assessed as reduction in viral replication measured after 48 hrs by qRT-PCR assay	[PMID: 33486200]
Vero C1008	EC₅₀	0.77 μM Compound: 52	Antiviral activity against SARS-CoV-2 infected in Vero E6 cells assessed as reduction in viral replication measured after 48 hrs by qRT-PCR assay Antiviral activity against SARS-CoV-2 infected in Vero E6 cells assessed as reduction in viral replication measured after 48 hrs by qRT-PCR assay	[PMID: 33486200]
Vero C1008	EC₅₀	3.01 μM Compound: Remdesivir	Antiviral activity against SARS coronavirus 2 infected in Vero E6 cells assessed as plague reduction measured after 1 hr Antiviral activity against SARS coronavirus 2 infected in Vero E6 cells assessed as plague reduction measured after 1 hr	[PMID: 33639344]
Vero C1008	CC₅₀	166 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero E6 cells infected with SARS-COV-2 by celltiter-glo luminescent cell viability assay Cytotoxicity against African green monkey Vero E6 cells infected with SARS-COV-2 by celltiter-glo luminescent cell viability assay	[PMID: 34273661]
Vero C1008	CC₅₀	72 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero E6 cells after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero E6 cells after 72 hrs by MTT assay	[PMID: 34408808]
Vero C1008	CC₅₀	373 μM Compound: RMV	Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 72 hrs by MTT assay	[PMID: 34534839]
Vero C1008	CC₅₀	>200 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34749200]
Vero C1008	CC₅₀	>10 μM Compound: GS-5734	Cytotoxicity against african green monkey Vero E6 cells by MTS assay Cytotoxicity against african green monkey Vero E6 cells by MTS assay	[PMID: 36455356]
Vero C1008	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against african green monkey Vero E6 cells assessed as reduction in cell viability after 26 hrs by MTS assay Cytotoxicity against african green monkey Vero E6 cells assessed as reduction in cell viability after 26 hrs by MTS assay	[PMID: 36475694]
Vero C1008	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against african green monkey Vero E6 cells assessed as inhibition of cell growth by CCK-8 assay Cytotoxicity against african green monkey Vero E6 cells assessed as inhibition of cell growth by CCK-8 assay	[PMID: 36965227]
Vero C1008	EC₅₀	770 nM Compound: GS-5734	Antiviral activity against SARS-COV-2 infected in African green monkey Vero E6 cells Antiviral activity against SARS-COV-2 infected in African green monkey Vero E6 cells	[PMID: 37229831]
Vero C1008	CC₅₀	608.3 μM Compound: Cpd III	Cytotoxicity against African green monkey Vero E6 cells measured after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero E6 cells measured after 72 hrs by MTT assay	[PMID: 37252103]
Vero C1008	CC₅₀	168 nM Compound: Remdesivir	Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 72 hrs by crystal violet staining based analysis Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 72 hrs by crystal violet staining based analysis	[PMID: 39004019]
Vero C1008	CC₅₀	>100 μM Compound: Remdesivir	Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 39028935]
Vero C1008	EC₅₀	1.65 μM Compound: Remdesivir	Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days	10.1101/2020.04.03.023846
Vero C1008	EC₅₀	0.62 μM Compound: Remdesivir	Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs	10.1101/2020.04.16.044016

In Vitro

Remdesivir inhibits MHV replication with an IC₅₀ of 1.1 μM in infected delayed brain tumor (DBT) cells with MHV^[1].
Remdesivir (2 μM, 2 h preinfection and 2 h postinfection) shows maximal inhibition in infected cells with MHV^[1].
Remdesivir (1-10 μM, 24-72 h) decreases SARS-CoV and MERS-CoV viral titer in HAE cells^[1].
Remdesivir inhibits 2019-nCoV with an EC₅₀ of 0.77 μM and CC₅₀ >100 μM^[2].
Remdesivir shows antiviral activity with EC₅₀ values of 3.3 μM, 4.7 μM, 32 μM, 3.7 μM and 9.2 μM for SARS-CoV-2 and its variants alpha, beta, gamma and delta, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Remdesivir (0.01-100 μM) reduces lung viral titers in mice models of WT and F480L + V557L SARS-CoV^[1].
Remdesivir (10 mg/kg, i.v.) shows 100% protection against Ebola virus infection in nonhuman primate (NHP) models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1809249-37-3
Appearance Solid
Molecular Weight 602.58
Formula C₂₇H₃₅N₆O₈P
Color Off-white to yellow
SMILES

C[C@H](N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@](C#N)(C3=CC=C4C(N)=NC=NN43)[C@H](O)[C@@H]2O)=O)C(OCC(CC)CC)=O
Synonyms

GS-5734
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (223)

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N Engl J Med

Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB. [Abstract]

2023 Jan 5;388(1):89-91. PMID: 36476720
Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Signal Transduct Target Ther

Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir. [Abstract]

2021 Feb 4;6(1):51. PMID: 33542181
Signal Transduct Target Ther

An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19. [Abstract]

2021 Apr 24;6(1):165. PMID: 33895786
Nature

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. [Abstract]

2021 May;593(7859):418-423 PMID: 33727703
Nature

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform. [Abstract]

2020 Jun;582(7813):561-565. PMID: 32365353

Remdesivir purchased from MedChemExpress. Usage Cited in: Nature. 2020 Jun;582(7813):561-565. [Abstract]

Remdesivir treatment showing the use of synSARS-CoV-2-GFP. Vero E6 cells were infected with synSARS-CoV-2-GFP (MOI = 0.01) and treated with 0.2 μM, 2 μM or without Remdesivir. DMSO was used as treatment in cells that were not incubated with Remdesivir. Mock, uninfected cells. At 48 h after infection, cells were analysed by fluorescence microscopy to detect GFP expression (left) and cell-culture supernatants were collected and titrated by TCID50 assay (right).
Science

Replication and single-cycle delivery of SARS-CoV-2 replicons. [Abstract]

2021 Nov 26;374(6571):1099-1106. PMID: 34648371

Remdesivir purchased from MedChemExpress. Usage Cited in: Science. 2021 Nov 26;374(6571):1099-1106. [Abstract]

Time course measurements of cell viability of Huh-7.5 cells electroporated with WT or Nsp1 K164A/H165A double mutant (Nsp1mut) Gluc replicon RNA. Cells were seeded with 100 nM Remdesivir or vehicle and were washed in phosphate-buffered saline 24 hours before each respective time-point collection. Mock-electroporated cells were used as controls for post-electroporation cell viability. The dashed line indicates the limit of detection. N = 4. Error bars indicate SD.
Science

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2020 Jun 26;368(6498):1499-1504. PMID: 32358203
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Remdesivir purchased from MedChemExpress. Usage Cited in: Cell Res. 2020 Mar;30(3):269-271. [Abstract]

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Remdesivir purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

Immunofluorescence of intracellular viral N protein. Intracellular expression of N protein was assessed by staining of infected Vero E6 cells with the polyclonal anti-N antibody (1:1000 dilution, green). Nuclei were stained with DAPI. CPE was shown in bright field. The results showed that Remdesivir (6.25 µmol/L) significantly inhibited N protein expression.
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Remdesivir purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 Aug;25(8):1223-1234. [Abstract]

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Endoplasmic reticulum stress and NF-kB activation in SARS-CoV-2 infected cells and their response to antiviral therapy. [Abstract]

2022 Jan;74(1):93-100. PMID: 34390301
mSphere

Development of a New Reverse Genetics System for Ebola Virus. [Abstract]

2021 May 5;6(3):e00235-21. PMID: 33952663
Biosaf Health

Drupacine as a potent SARS-CoV-2 replication inhibitor in vitro. [Abstract]

2024 Sep 3;6(5):270-278. PMID: 40078736
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The mechanism and effects of remdesivir-induced developmental toxicity in zebrafish: Blood flow dysfunction and behavioral alterations. [Abstract]

2022 Oct;42(10):1688-1700. PMID: 35560222
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Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS-441524 in patients with COVID-19: A limited case series. [Abstract]

2022 Mar;15(3):732-740. PMID: 34761554
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Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database. [Abstract]

2022 Feb;15(2):501-513. PMID: 34719115
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Development and validation of a simple, selective, and sensitive LC-MS/MS assay for the quantification of remdesivir in human plasma. [Abstract]

2021 May 1:1171:122641. PMID: 33756448
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Characterization of minigenome systems for Hantaan and Seoul hantaviruses. [Abstract]

2026 Jan:363:199678. PMID: 41419169
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Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection. [Abstract]

2025 Feb 5;20(2):e0316952. PMID: 39908288
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Synergistic drug combinations designed to fully suppress SARS-CoV-2 in the lung of COVID-19 patients. [Abstract]

2022 Nov 10;17(11):e0276751. PMID: 36355808
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RETRACTED ARTICLE: Discovery of (E)- N-(4-cyanobenzylidene)-6-fluoro-3-hydroxypyrazine-2-carboxamide (cyanorona-20): the first potent and specific anti-COVID-19 drug. [Abstract]

2021;75(9):4669-4685. PMID: 34025012
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Remdesivir and Human Milk: A Case Study. [Abstract]

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Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (165.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6595 mL

8.2977 mL

16.5953 mL

5 mM

0.3319 mL

1.6595 mL

3.3191 mL

10 mM

0.1660 mL

0.8298 mL

1.6595 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (4.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.17 mg/mL (3.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.17 mg/mL (3.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (558 KB)
- English - EN (558 KB)
- Français - FR (558 KB)
- Deutsch - DE (558 KB)
- Norwegian - NO (558 KB)
- Español - ES (558 KB)
- Swedish - SV (558 KB)
- Italian - IT (558 KB)
- Korean - KR (558 KB)
- Portuguese - PT (558 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18. [Content Brief]

[2]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. [Content Brief]

[3]. Hu H, et al. Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity. J Med Chem. 2022 Sep 22;65(18):12044-12054. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6595 mL	8.2977 mL	16.5953 mL	41.4883 mL
	5 mM	0.3319 mL	1.6595 mL	3.3191 mL	8.2977 mL
	10 mM	0.1660 mL	0.8298 mL	1.6595 mL	4.1488 mL
	15 mM	0.1106 mL	0.5532 mL	1.1064 mL	2.7659 mL
	20 mM	0.0830 mL	0.4149 mL	0.8298 mL	2.0744 mL
	25 mM	0.0664 mL	0.3319 mL	0.6638 mL	1.6595 mL
	30 mM	0.0553 mL	0.2766 mL	0.5532 mL	1.3829 mL
	40 mM	0.0415 mL	0.2074 mL	0.4149 mL	1.0372 mL
	50 mM	0.0332 mL	0.1660 mL	0.3319 mL	0.8298 mL
	60 mM	0.0277 mL	0.1383 mL	0.2766 mL	0.6915 mL
	80 mM	0.0207 mL	0.1037 mL	0.2074 mL	0.5186 mL
	100 mM	0.0166 mL	0.0830 mL	0.1660 mL	0.4149 mL

Keywords

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Remdesivir

Anti-Infection Compound Library

Cell Cycle/DNA Damage Compound Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

Antiviral Compound Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Covalent Screening Library

Anti-COVID-19 Compound Library

FDA Approved & Pharmacopeial Drug Library

Drug-Induced Liver Injury (DILI) Compound Library

Rare Diseases Drug Library

EMA-Approved Drug Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Non-steroidal Anti-Inflammatory Compound Library

Heterocyclic Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Classic FDA-Approved Drug Library

Publications Citing Use of MedChemExpress (MCE) Remdesivir

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Publications (223)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Remdesivir

Anti-Infection Compound Library

Cell Cycle/DNA Damage Compound Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

Antiviral Compound Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Covalent Screening Library

Anti-COVID-19 Compound Library

FDA Approved & Pharmacopeial Drug Library

Drug-Induced Liver Injury (DILI) Compound Library

Rare Diseases Drug Library

EMA-Approved Drug Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Non-steroidal Anti-Inflammatory Compound Library

Heterocyclic Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Classic FDA-Approved Drug Library

Publications Citing Use of MedChemExpress (MCE) Remdesivir

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Publications (223)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Remdesivir Related Classifications

Cat. No.: HY-104077