1. Anti-infection
  2. SARS-CoV
  3. Remdesivir

Remdesivir (Synonyms: GS-5734)

Cat. No.: HY-104077 Purity: 99.74%
Handling Instructions

Remdesivir (GS-5734) is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of 2019-nCoV (COVID-19) infection in vitro.

For research use only. We do not sell to patients.

Remdesivir Chemical Structure

Remdesivir Chemical Structure

CAS No. : 1809249-37-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 729 In-stock
Estimated Time of Arrival: December 31
1 mg USD 220 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

Remdesivir (GS-5734) is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of 2019-nCoV (COVID-19) infection in vitro.

IC50 & Target

EC50: 30 nM (murine hepatitis virus, delayed brain tumor cell), 74 nM (SARS-CoV, HAE cell), 74 nM (MERS-CoV, HAE cell)[1]

In Vitro

Remdesivir (GS-5734) is a potent antiviral agent. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h[1].

Clinical Trial
Molecular Weight

602.58

Formula

C₂₇H₃₅N₆O₈P

CAS No.

1809249-37-3

SMILES

C[[email protected]](N[[email protected]@](OC1=CC=CC=C1)(OC[[email protected]]2O[[email protected]@](C#N)(C3=CC=C4C(N)=NC=NN43)[[email protected]](O)[[email protected]@H]2O)=O)C(OCC(CC)CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (207.44 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6595 mL 8.2977 mL 16.5953 mL
5 mM 0.3319 mL 1.6595 mL 3.3191 mL
10 mM 0.1660 mL 0.8298 mL 1.6595 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (3.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (3.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (3.60 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.74%

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Keywords:

RemdesivirGS-5734GS5734GS 5734SARS-CoVSARS coronavirusantiviralMERS-CoV2019-nCoVCOVID-19infectionInhibitorinhibitorinhibit

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Remdesivir
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