Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir

  • Signal Transduct Target Ther. 2021 Feb 4;6(1):51. doi: 10.1038/s41392-021-00468-9.
Yu Bai   #  1  2 ,  Fei Ye   #  3 ,  Yong Feng   #  1  2 ,  Hanyi Liao  1  2 ,  Hao Song  4 ,  Jianxun Qi  1  2 ,  George Fu Gao  1  2  5 ,  Wenjie Tan  6 ,  Lifeng Fu  7  8 ,  Yi Shi  9  10  11
Affiliations
  • 1. Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • 2. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
  • 3. NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, 102206, China.
  • 4. Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China.
  • 5. Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, Beijing, 100101, China.
  • 6. Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China. [email protected].
  • 7. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. [email protected].
  • 8. Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. [email protected].
  • 9. Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China. [email protected].
  • 10. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. [email protected].
  • 11. Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. [email protected].
  • # Contributed equally.
PMID: 33542181 DOI: 10.1038/s41392-021-00468-9
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