Complement Factor H Related 4
Complement factor H-related protein 4 (CFHR4) is the largest FHR family member and occurs as two splice isoforms, CFHR4A and CFHR4B, which differ in domain composition. Unlike other FHR proteins, CFHR4A binds C1q, and CFHR4 has been found deposited on microbial surfaces and in the choroidal neovascular lesions of age-related macular degeneration, where it can locally enhance complement activation. The gene sits within the CFHR cluster at chromosome 1q32 whose copy-number variation shapes disease risk. Recombinant CFHR4 supports studies of isoform-specific binding, C1q interaction, and complement deregulation in ocular disease.
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Complement Factor H Related 4 Recombinant Proteins (1)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
