1. MAPK/ERK Pathway
  2. p38 MAPK

p38 MAPK

p38 MAPK (p38 mitogen-activated protein kinase) is a class of mitogen-activated protein kinases that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, andosmotic shock, and are involved in cell differentiation, apoptosis and autophagy. p38 MAPK is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signaling cascade controlling cellular responses to cytokines and stress. Four p38 MAPK, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12/ERK6), and -δ (MAPK13/SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), ultraviolet light, and growth factors.

p38 MAPK Related Products (30):

Cat. No. Product Name Effect Purity
  • HY-10256
    SB 203580 Inhibitor 99.54%
    SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-10295
    SB 202190 Inhibitor 99.17%
    SB 202190 inhibits p38 and p38β2 with IC50 values of 50 nM and 100 nM. respectively.
  • HY-13241
    LY2228820 Inhibitor 99.94%
    LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM in a cell-free assay, but does not alter p38 MAPK activation.
  • HY-10256A
    SB 203580 hydrochloride Inhibitor 99.71%
    SB 203580 hydrochloride is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-10320
    Doramapimod Inhibitor 99.4%
    Doramapimod is a highly potent p38α inhibitor with an IC50 of 4 nM, also inhibits B-Raf with an IC50 of 83 nM and Abl with an IC50 of 14.6 μM.
  • HY-16715
    Acumapimod Inhibitor 99.14%
    Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.
  • HY-N0674A
    Dehydrocorydaline chloride Activator 99.95%
    Dehydrocorydaline chloride is an alkaloidal that has anti-inflammatory and anti-cancer activities.
  • HY-10405
    Pamapimod Inhibitor 99.86%
    Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor.
  • HY-10402
    Losmapimod Inhibitor 99.08%
    Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
  • HY-12048
    Chelerythrine Chloride Inhibitor 99.82%
    Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C and mitogen-activated protein kinase (MAPK), with IC50 of 660 nM for PKC, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
  • HY-100343
    GNE-495 Inhibitor 98.79%
    GNE-495 is a potent and Selective MAP4K4 Inhibitor with IC50 of 3.7 nM.
  • HY-10328
    VX-745 Inhibitor >98.0%
    VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.
  • HY-10578
    PD 169316 Inhibitor
    PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM).
  • HY-10401
    VX-702 Inhibitor 99.54%
    VX-702 is a highly selective inhibitor of p38α MAPK(IC50=4 -20 nM), 14-fold higher potency against the p38α versus p38β.
  • HY-11068
    SB 239063 Inhibitor 99.49%
    SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α).
  • HY-10456
    TAK-715 Inhibitor 99.97%
    TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
  • HY-18306
    SB 242235 Inhibitor 99.63%
    SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 uM.
  • HY-10403
    PH-797804 Inhibitor
    PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM; 4-fold more selective versus p38β and does not inhibit JNK2.
  • HY-10406
    SCIO-469 Inhibitor 98.07%
    SCIO-469 is a selective ATP-competitive p38 inhibitor with IC50 of 9 nM for p38αin vitro, about 10-fold selectivity for p38α over p38β, and at least 2000-fold selectivity for p38α over an in vitro panel of 20 other kinases, including other MAK kinases.
  • HY-14975
    R1487 Hydrochloride Inhibitor 98.68%
    R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α.