1. MAPK/ERK Pathway
  2. p38 MAPK

p38 MAPK

p38 MAPK (p38 mitogen-activated protein kinase) is a class of mitogen-activated protein kinases that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, andosmotic shock, and are involved in cell differentiation, apoptosis and autophagy. p38 MAPK is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signaling cascade controlling cellular responses to cytokines and stress. Four p38 MAPK, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12/ERK6), and -δ (MAPK13/SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), ultraviolet light, and growth factors.

p38 MAPK Related Products (30):

Cat. No. Product Name Effect Purity
  • HY-10256
    SB 203580 Inhibitor
    SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-10295
    SB 202190 Inhibitor
    SB 202190 inhibits p38 and p38β2 with IC50 values of 50 nM and 100 nM. respectively.
  • HY-13241
    LY2228820 Inhibitor
    LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM in a cell-free assay, but does not alter p38 MAPK activation.
  • HY-10256A
    SB 203580 hydrochloride Inhibitor
    SB 203580 hydrochloride is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-10320
    Doramapimod Inhibitor
    Doramapimod is a highly potent p38α inhibitor with an IC50 of 4 nM, also inhibits B-Raf with an IC50 of 83 nM and Abl with an IC50 of 14.6 μM.
  • HY-16715
    Acumapimod Inhibitor
    Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.
  • HY-10405
    Pamapimod Inhibitor
    Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor.
  • HY-10402
    Losmapimod Inhibitor
    Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
  • HY-12048
    Chelerythrine Chloride Inhibitor
    Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C and mitogen-activated protein kinase (MAPK), with IC50 of 660 nM for PKC, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
  • HY-10578
    PD 169316 Inhibitor
    PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM).
  • HY-10328
    VX-745 Inhibitor
    VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.
  • HY-10401
    VX-702 Inhibitor
    VX-702 is a highly selective inhibitor of p38α MAPK(IC50=4 -20 nM), 14-fold higher potency against the p38α versus p38β.
  • HY-11068
    SB 239063 Inhibitor
    SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α).
  • HY-10456
    TAK-715 Inhibitor
    TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
  • HY-18306
    SB 242235 Inhibitor
    SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 uM.
  • HY-10406
    SCIO-469 Inhibitor
    SCIO-469 is a selective ATP-competitive p38 inhibitor with IC50 of 9 nM for p38αin vitro, about 10-fold selectivity for p38α over p38β, and at least 2000-fold selectivity for p38α over an in vitro panel of 20 other kinases, including other MAK kinases.
  • HY-14975
    R1487 Hydrochloride Inhibitor
    R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α.
  • HY-12839
    p38 MAPK-IN-1 Inhibitor
    p38 MAPK-IN-1 is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM, shows sustained levels, low clearance and good bioavailability.
  • HY-12511
    SKF-86002 Inhibitor
    SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).
  • HY-15300
    Skepinone-L Inhibitor
    Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.