1. MAPK/ERK Pathway
  2. p38 MAPK

p38 MAPK

The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP). It is well known that p38 is involved in inflammation, apoptosis, cardiomyocyte hypertrophy and cell differentiation.

The p38 MAPK family is composed of four proteins: p38α (encoded by the gene Mapk14), p38β (Mapk11), p38γ (Mapk12), and p38δ (Mapk13). Their coding genes have a distinct tissue distribution and they appear differentially expressed, being Mapk14 the most highly expressed. p38 MAPKs are substrates for three MAP2K (MKK6, MKK3, and MKK4). The contribution of each of these MAP2K to p38 MAPKs activation depends on the stimulus and the cell type. The MAP3Ks that lead to p38 MAPKs activation are ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1.

p38 MAPK Related Products (33):

Cat. No. Product Name Effect Purity
  • HY-10256
    SB 203580 Inhibitor 99.54%
    SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-10295
    SB 202190 Inhibitor 99.88%
    SB 202190 inhibits p38 and p38β2 with IC50 values of 50 nM and 100 nM. respectively.
  • HY-10256A
    SB 203580 hydrochloride Inhibitor 99.71%
    SB 203580 hydrochloride is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-10320
    Doramapimod Inhibitor 99.72%
    Doramapimod is a highly potent p38α inhibitor with an IC50 of 4 nM, also inhibits B-Raf with an IC50 of 83 nM and Abl with an IC50 of 14.6 μM.
  • HY-13241
    LY2228820 Inhibitor 99.94%
    LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM in a cell-free assay, but does not alter p38 MAPK activation.
  • HY-18874
    p38-α MAPK-IN-1 Inhibitor 99.92%
    p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.
  • HY-10402
    Losmapimod Inhibitor
    Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
  • HY-12048
    Chelerythrine Chloride Inhibitor >98.0%
    Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C and mitogen-activated protein kinase (MAPK), with IC50 of 660 nM for PKC, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
  • HY-10578
    PD 169316 Inhibitor
    PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM.
  • HY-P0117
    Tat-NR2B9c Inhibitor 98.22%
    Tat-NR2B9c is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1; also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy.
  • HY-10406
    SCIO-469 Inhibitor 98.07%
    SCIO-469 is a selective ATP-competitive p38 inhibitor with IC50 of 9 nM for p38αin vitro, about 10-fold selectivity for p38α over p38β, and at least 2000-fold selectivity for p38α over an in vitro panel of 20 other kinases, including other MAK kinases.
  • HY-10328
    VX-745 Inhibitor 98.74%
    VX-745 is a potent and selective inhibitor of p38α, and possesses anti-inflammatory activity.
  • HY-11068
    SB 239063 Inhibitor 99.53%
    SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α).
  • HY-10401
    VX-702 Inhibitor 99.54%
    VX-702 is a highly selective inhibitor of p38α MAPK(IC50=4 -20 nM), 14-fold higher potency against the p38α versus p38β.
  • HY-10456
    TAK-715 Inhibitor 99.93%
    TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
  • HY-15027
    5-Aminosalicylic acid Inhibitor >98.0%
    5-Aminosalicylic acid is an anti-inflammatory compound.
  • HY-14975
    R1487 Hydrochloride Inhibitor 98.68%
    R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α.
  • HY-14305A
    BMS-582949 hydrochloride Inhibitor 98.83%
    BMS-582949 hydrochloride is a novel highly selective p38α MAPK inhibitor, inhibits p38α with IC50 of 13 nM.
  • HY-18306
    SB 242235 Inhibitor 99.63%
    SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 uM.
  • HY-10403
    PH-797804 Inhibitor 98.20%
    PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM; 4-fold more selective versus p38β and does not inhibit JNK2.