1. Signaling Pathways
  2. Immunology/Inflammation
  3. COX
  4. COX-1 Inhibitors

COX-1 Inhibitors

COX

COX-1

COX-2

COX-3

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Sorry. There is currently no product that acts on isoform COX-1 together.

Please try each isoform separately.

COX-1 Specific Inhibitors
Product Name COX-1 COX-2 COX-1 Selectivity Purity
Aspirin
COX-1, IC50: 27.75 μM
COX-2, IC50: 1.17 mM
Selective Inhibitor >99.0%
Imrecoxib
Human COX-1, IC50: 115 nM
Human COX-2, IC50: 18 nM
Selective Inhibitor >99.0%
Ibuprofen
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
Selective Inhibitor 99.99%
(-)-Epicatechin gallate
COX-1, IC50: 7.5 μM
  Selective Inhibitor 98.57%
Catechin
COX-1, IC50: 1.4 μM
  Selective Inhibitor >99.0%
SC-560
COX-1, IC50: 9 nM
COX-2, IC50: 6.3 μM
Selective Inhibitor 99.58%
Ketoprofen
COX-1, IC50: 2 nM (in human blood monocytes)
COX-2, IC50: 26 nM (in human blood monocytes)
Selective Inhibitor 99.80%
(-)-Epicatechin
COX-1, IC50: 3.2 μM
  Selective Inhibitor 99.00%
S-(+)-Ketoprofen
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
Selective Inhibitor 99.95%
Oxaprozin
COX-1, IC50: 2.2 μM
COX-2, IC50: 36 μM
Selective Inhibitor 99.63%
Mefenamic acid
hCOX-1, IC50: 40 nM
hCOX-2, IC50: 3 μM
Selective Inhibitor 99.99%
TFAP
COX-1, IC50: 0.8 μM
  Selective Inhibitor 99.97%
(+)-Catechin hydrate
COX-1, IC50: 1.4 μM
  Selective Inhibitor 99.22%
Acemetacin
COX-1, IC50: 85 μM (in human intact cell)
  Selective Inhibitor 99.97%
Nitroaspirin
COX-1
  Selective Inhibitor
Tenidap
COX-1, IC50: 0.03 μM
COX-2, IC50: 1.2 μM
Selective Inhibitor
α-Spinasterol
COX-1, IC50: 16.17 μM
COX-2, IC50: 7.76 μM
Selective Inhibitor
Celecoxib
COX-1, IC50: 15 μM
COX-2, IC50: 40 nM
Pan Inhibitor 99.50%
Acetaminophen
COX-1, IC50: 113.7 μM
COX-2, IC50: 25.8 μM
Pan Inhibitor 99.69%
Indomethacin
Human COX-1, IC50: 18 nM (in CHO cells)
Human COX-2, IC50: 26 nM (in CHO cells)
Pan Inhibitor >98.0%
Diclofenac
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
Pan Inhibitor 99.98%
Meloxicam
COX-1, IC50: 36.6 μM
COX-2, IC50: 0.49 μM
Pan Inhibitor 98.07%
Carprofen
COX-1, IC50: 22.3 μM
COX-2, IC50: 3.9 μM
Pan Inhibitor 99.76%
Naproxen
COX-1, IC50: 9.55 μM
COX-2, IC50: 5.65 μM
Pan Inhibitor 99.66%
Rutaecarpine
COX-1, IC50: 8.7 μM (in BMMC)
COX-2, IC50: 0.28 μM (in BMMC)
Pan Inhibitor 99.11%
Piroxicam
COX-1, IC50: 47 μM (in human monocytes)
COX-2, IC50: 25 μM (in human monocytes)
Pan Inhibitor 99.73%
Diclofenac Sodium
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
Pan Inhibitor >98.0%
Ketorolac tromethamine salt
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
Pan Inhibitor 99.94%
Valdecoxib
COX-1, IC50: 140 μM
COX-2, IC50: 5 nM
Pan Inhibitor 99.91%
Naproxen sodium
COX-1, IC50: 9.55 μM (in intact cells )
COX-2, IC50: 5.65 μM (in intact cells )
Pan Inhibitor 99.98%
Aceclofenac
COX-1, IC50: 7.3 μM
COX-2, IC50: 3 μM
Pan Inhibitor 99.80%
Etoricoxib
COX-1, IC50: 116 μM (in human whole blood)
COX-2, IC50: 1.1 μM (in human whole blood)
Pan Inhibitor 99.92%
Tenoxicam
COX-1
COX-2
Pan Inhibitor 99.83%
(-)-Catechin gallate
COX-1
COX-2
Pan Inhibitor 99.98%
Phenylbutazone
COX-1, IC50: 3.7 μM
COX-2, IC50: 1.1 μM
Pan Inhibitor 98.86%
Firocoxib
COX-1, IC50: 7.5 μM
COX-2, IC50: 0.13 μM
Pan Inhibitor 99.50%
Loxoprofen
COX-1, IC50: 6.5 μM (in human whole blood)
COX-2, IC50: 13.5 μM (in human whole blood)
Pan Inhibitor 98.82%
Etodolac
COX-1, IC50: ∼50000 nM (in CHO cells)
COX-2, IC50: 41 nM (in CHO cells)
Pan Inhibitor 99.10%
Lornoxicam
COX-1, IC50: 5 nM (in cells)
COX-2, IC50: 45 nM (in cells)
Pan Inhibitor 98.31%
Flunixin meglumine
COX-1, IC50: 17 nM
COX-2, IC50: 0.4 nM
Pan Inhibitor 99.65%
Nepafenac
COX-1, IC50: 64.3 μM
  Pan Inhibitor 95.14%
Diclofenac diethylamine
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
Pan Inhibitor 99.93%
Roburic acid
COX-1, IC50: 5 μM
COX-2, IC50: 9 μM
Pan Inhibitor
(E)-Ethyl p-methoxycinnamate
COX-1, IC50: 1.12 μM
COX-2, IC50: 0.83 μM
Pan Inhibitor
N-trans-Feruloyltyramine
COX-1
COX-2
Pan Inhibitor
Zaltoprofen
COX-1, IC50: 149 μM
COX-2, IC50: 111 μM
Pan Inhibitor 99.09%
S-2474
COX-1, IC50: 27 μM
COX-2, IC50: 11 nM
Pan Inhibitor
Ketorolac
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
Pan Inhibitor