1. Signaling Pathways
  2. Immunology/Inflammation
  3. COX
  4. COX-1 Inhibitors

COX-1 Inhibitors

COX

COX-1

COX-2

COX-3

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Sorry. There is currently no product that acts on isoform COX-1 together.

Please try each isoform separately.

COX-1 Specific Inhibitors
Product Name COX-1 COX COX-2 COX-1 Selectivity Purity
Aspirin
COX-1, IC50: 27.75 μM
 
COX-2, IC50: 1.17 mM
Selective Inhibitor ≥99.0%
Ibuprofen
COX-1, IC50: 13 μM
 
COX-2, IC50: 370 μM
Selective Inhibitor 99.97%
Mofezolac
COX-1, IC50: 1.44 nM
 
COX-2, IC50: 447 nM
Selective Inhibitor 98.83%
Catechin
COX-1, IC50: 1.4 μM
    Selective Inhibitor ≥99.0%
(-)-Epicatechin
COX-1, IC50: 3.2 μM
    Selective Inhibitor 99.0%
SC-560
COX-1, IC50: 9 nM
 
COX-2, IC50: 6.3 μM
Selective Inhibitor 99.80%
Ketoprofen
COX-1, IC50: 2 nM (in human blood monocytes)
 
COX-2, IC50: 26 nM (in human blood monocytes)
Selective Inhibitor 99.93%
(-)-Epicatechin gallate
COX-1, IC50: 7.5 μM
    Selective Inhibitor 98.57%
Imrecoxib
Human COX-1, IC50: 115 nM
 
Human COX-2, IC50: 18 nM
Selective Inhibitor ≥99.0%
(+)-Catechin hydrate
COX-1, IC50: 1.4 μM
    Selective Inhibitor 99.59%
Mefenamic acid
hCOX-1, IC50: 40 nM
 
hCOX-2, IC50: 3 μM
Selective Inhibitor 99.97%
S-(+)-Ketoprofen
COX-1, IC50: 13 μM
 
COX-2, IC50: 370 μM
Selective Inhibitor 99.93%
Acemetacin
COX-1, IC50: 85 μM (in human intact cell)
    Selective Inhibitor 99.97%
PTUPB
COX-1, IC50: 1.26 μM
COX-1, IC50: 100 μM
    Selective Inhibitor 98.82%
Oxaprozin
COX-1, IC50: 2.2 μM
 
COX-2, IC50: 36 μM
Selective Inhibitor 99.76%
Tenidap
COX-1, IC50: 0.03 μM
 
COX-2, IC50: 1.2 μM
Selective Inhibitor ≥99.0%
TFAP
COX-1, IC50: 0.8 μM
    Selective Inhibitor 99.97%
Gnetol
COX-1, IC50: 0.78 μM
    Selective Inhibitor ≥98.0%
α-Spinasterol
COX-1, IC50: 16.17 μM
 
COX-2, IC50: 7.76 μM
Selective Inhibitor 99.15%
Teriflunomide impurity 3
COX-1, IC50: 30 μM
    Selective Inhibitor 99.87%
Nitroaspirin
COX-1
    Selective Inhibitor
Floctafenine
COX-1
 
COX-2
Selective Inhibitor
Acetaminophen
COX-1, IC50: 113.7 μM
 
COX-2, IC50: 25.8 μM
Pan Inhibitor 99.96%
Indomethacin
Human COX-1, IC50: 18 nM (in CHO cells)
 
Human COX-2, IC50: 26 nM (in CHO cells)
Pan Inhibitor 99.97%
Celecoxib
COX-1, IC50: 15 μM
 
COX-2, IC50: 40 nM
Pan Inhibitor 99.59%
Lumiracoxib
COX-1, Ki: 3 μM
 
COX-2, Ki: 0.06 μM
Pan Inhibitor ≥98.0%
Diclofenac
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
 
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
Pan Inhibitor 99.97%
Diclofenac Sodium
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
 
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
Pan Inhibitor 99.93%
Naproxen
COX-1, IC50: 9.55 μM
 
COX-2, IC50: 5.65 μM
Pan Inhibitor ≥98.0%
Carprofen
COX-1, IC50: 22.3 μM
 
COX-2, IC50: 3.9 μM
Pan Inhibitor 99.96%
Rutaecarpine
COX-1, IC50: 8.7 μM (in BMMC)
 
COX-2, IC50: 0.28 μM (in BMMC)
Pan Inhibitor 98.11%
Meloxicam
COX-1, IC50: 36.6 μM
 
COX-2, IC50: 0.49 μM
Pan Inhibitor 99.88%
Flurbiprofen
COX-1
COX
COX-2
Pan Inhibitor 99.92%
Piroxicam
COX-1, IC50: 47 μM (in human monocytes)
 
COX-2, IC50: 25 μM (in human monocytes)
Pan Inhibitor 99.61%
Etoricoxib
COX-1, IC50: 116 μM (in human whole blood)
 
COX-2, IC50: 1.1 μM (in human whole blood)
Pan Inhibitor 99.10%
Ketorolac tromethamine salt
COX-1, IC50: 20 nM
 
COX-2, IC50: 120 nM
Pan Inhibitor 99.94%
(S)-Flurbiprofen
COX-1, IC50: 0.48 μM
 
COX-2, IC50: 0.47 μM
Pan Inhibitor 99.83%
Bromfenac sodium hydrate
COX-1, IC50: 5.56 nM
 
COX-2, IC50: 7.45 nM
Pan Inhibitor 99.91%
Otenaproxesul
COX-1
 
COX-2
Pan Inhibitor 98.35%
Fenbufen
COX-1, IC50: 3.9 μM
 
COX-2, IC50: 8.1 μM
Pan Inhibitor 98.99%
(-)-Catechin gallate
COX-1
 
COX-2
Pan Inhibitor 99.98%
Etodolac
COX-1, IC50: ∼50000 nM (in CHO cells)
 
COX-2, IC50: 41 nM (in CHO cells)
Pan Inhibitor 99.11%
Diclofenac diethylamine
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
 
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
Pan Inhibitor 99.93%
SC-236
COX-1, IC50: 17.8 μM
 
COX-2, IC50: 10 nM
Pan Inhibitor 99.24%
Lornoxicam
COX-1, IC50: 5 nM (in cells)
 
COX-2, IC50: 45 nM (in cells)
Pan Inhibitor 99.84%
Valdecoxib
COX-1, IC50: 140 μM
 
COX-2, IC50: 5 nM
Pan Inhibitor 99.96%
Harpagoside
COX-1
 
COX-2
Pan Inhibitor 98.35%
Tolmetin
Human COX-1, IC50: 0.35 μM
 
Human COX-2, IC50: 0.82 μM
Pan Inhibitor ≥98.0%
Pranoprofen
COX-1
 
COX-2
Pan Inhibitor 99.37%
Naproxen sodium
COX-1, IC50: 9.55 μM (in intact cells )
 
COX-2, IC50: 5.65 μM (in intact cells )
Pan Inhibitor ≥98.0%
Tenoxicam
COX-1
 
COX-2
Pan Inhibitor 99.94%
Zaltoprofen
COX-1, IC50: 1.3 μM
 
COX-2, IC50: 0.34 μM
Pan Inhibitor ≥98.0%
CAY10404
COX-1, IC50: >500 μM
 
COX-2, IC50: 1 nM
Pan Inhibitor ≥99.0%
Columbin
COX-1, EC50: 327 μM
 
COX-2, EC50: 53.1 μM
Pan Inhibitor 98.86%
Nepafenac
COX-1, IC50: 64.3 μM
    Pan Inhibitor 99.51%
Firocoxib
COX-1, IC50: 7.5 μM
 
COX-2, IC50: 0.13 μM
Pan Inhibitor 98.42%
(S)-(+)-Ibuprofen
COX-1, IC50: 2.1 μM
 
COX-2, IC50: 1.6 μM
Pan Inhibitor 99.98%
Flunixin meglumine
COX-1, IC50: 17 nM
 
COX-2, IC50: 0.4 nM
Pan Inhibitor 99.65%
Bromfenac sodium
COX-1, IC50: 5.56 nM
 
COX-2, IC50: 7.45 nM
Pan Inhibitor
Isoxicam
COX-1
 
COX-2
Pan Inhibitor 99.11%
Aceclofenac
COX-1, IC50: 7.3 μM
 
COX-2, IC50: 3 μM
Pan Inhibitor 99.75%
Diclofenac potassium
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 nM
 
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 nM
Pan Inhibitor ≥98.0%
Ketorolac D5
COX-1, IC50: 20 nM
 
COX-2, IC50: 120 nM
Pan Inhibitor ≥98.0%
AG-024322
COX-1, Ki: 2.3 nM
 
COX-2, Ki: 3 nM
Pan Inhibitor 98.69%
(E)-Ethyl p-methoxycinnamate
COX-1, IC50: 1.12 μM
 
COX-2, IC50: 0.83 μM
Pan Inhibitor 99.39%
N-trans-Feruloyltyramine
COX-1
 
COX-2
Pan Inhibitor 98.64%
Loxoprofen
COX-1, IC50: 6.5 μM (in human whole blood)
 
COX-2, IC50: 13.5 μM (in human whole blood)
Pan Inhibitor 99.76%
Tolmetin sodium dihydrate
Human COX-1, IC50: 0.35 μM
 
Human COX-2, IC50: 0.82 μM
Pan Inhibitor 99.77%
Loxoprofen sodium
COX-1, IC50: 6.5 μM
 
COX-2, IC50: 13.5 μM
Pan Inhibitor ≥98.0%
DuP-697
hCOX-1, IC50: 800 nM
 
hCOX-2, IC50: 10 nM
Pan Inhibitor
Roburic acid
COX-1, IC50: 5 μM
 
COX-2, IC50: 9 μM
Pan Inhibitor
Indomethacin-D4
Human COX-1, IC50: 18 nM (in CHO cells)
 
Human COX-2, IC50: 26 nM (in CHO cells)
Pan Inhibitor
(S)-(+)-Ibuprofen D3
COX-1, IC50: 2.1 μM
 
COX-2, IC50: 1.6 μM
Pan Inhibitor
Taraxerol acetate
COX-1, IC50: 116.3 μM
 
COX-2, IC50: 94.7 μM
Pan Inhibitor
Plantanone B
Ovine COX-1, IC50: 21.78±0.2 μM
 
Ovine COX-2, IC50: 44.01±0.42 μM
Pan Inhibitor
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone
COX-1
 
COX-2
Pan Inhibitor
Mefenamic acid D4
hCOX-1, IC50: 40 nM
 
hCOX-2, IC50: 3 nM
Pan Inhibitor
Hamaudol
COX-1, IC50: 0.3 mM
 
COX-2, IC50: 0.57 mM
Pan Inhibitor
SC-58125
hCOX-1, IC50: >100 μM
 
hCOX-2, IC50: 0.04 μM
Pan Inhibitor
Eltenac
COX-1, IC50: 0.03 μM
 
COX-2, IC50: 0.03 μM
Pan Inhibitor
Ketorolac
COX-1, IC50: 20 nM
 
COX-2, IC50: 120 nM
Pan Inhibitor
S-2474
COX-1, IC50: 27 μM
 
COX-2, IC50: 11 nM
Pan Inhibitor
Xanthohumol
COX-1
 
COX-2
Inhibitor 99.84%