1257-08-5
1257-08-5
Chemical Structure
(-)-Epicatechin gallate
Synonym(s): Epicatechin gallate; ECG;(-)-Epicatechin 3-O-gallate
- CAS No.: 1257-08-5
- Formula:C22H18O10
- Molecular Weight:442.37
IUPAC Name: (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate
InChIKey: LSHVYAFMTMFKBA-TZIWHRDSSA-N
SMILES: O=C(O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1)C4=CC(O)=C(O)C(O)=C4
Biological Activity: (-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM[1][2]. (-)-Epicatechin gallate is a GLUT1 and GLUT5 inhibitor. (-)-Epicatechin gallate decreases cell growth of GLUT5-expressing hxt0 yeast cells[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(-)-Epicatechin gallate | 99.96% | (-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM. (-)-Epicatechin gallate is a GLUT1 and GLUT5 inhibitor. (-)-Epicatechin gallate decreases cell growth of GLUT5-expressing hxt0 yeast cells. | ||||||||||||||||||||
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(-)-Epicatechin gallate (Standard) | 97.68% | (-)-Epicatechin gallate (Standard) is the analytical standard of (-)-Epicatechin gallate. This product is intended for research and analytical applications. (-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM. (-)-Epicatechin gallate is a GLUT1 and GLUT5 inhibitor. (-)-Epicatechin gallate decreases cell growth of GLUT5-expressing hxt0 yeast cells. | ||||||||||||||||||||
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References
- [1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9. [Content Brief]
- [2]. Takizawa Y, et al. Pharmacokinetics of (-)-epicatechin-3-O-gallate, an active component of Onpi-to, in rats. Biol Pharm Bull. 2003 May;26(5):608-12. [Content Brief]
- [3]. Tripp J, et al. Establishing a yeast-based screening system for discovery of human GLUT5 inhibitors and activators. Sci Rep. 2017 Jul 24;7(1):6197. [Content Brief]
