1. Immunology/Inflammation
  2. COX
  3. (-)-Catechin gallate

(-)-Catechin gallate (Synonyms: (-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate)

Cat. No.: HY-N0356 Purity: 99.98%
Handling Instructions

(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.

For research use only. We do not sell to patients.

(-)-Catechin gallate Chemical Structure

(-)-Catechin gallate Chemical Structure

CAS No. : 130405-40-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 337 In-stock
Estimated Time of Arrival: December 31
5 mg USD 306 In-stock
Estimated Time of Arrival: December 31
10 mg USD 492 In-stock
Estimated Time of Arrival: December 31
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Description

(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.

IC50 & Target[1]

COX-1

 

COX-2

 

In Vitro

(-)-Catechin gallate (CG) directly interacts with DNA oligomers and inhibits the activity of COX-1 and COX-2 enzymes, the gene expression of matrix metalloproteinase-9 in macrophage-differentiated HL-60 myeloid leukemia cells, the adipocyte uptake of glucose by the transporter, GLUT4, and the activities of various proteasomes, i.e., the multicatalytic proteases responsible for the degradation of most cellular proteins. The relative cytotoxicities of a 3-day exposure to (-)-Catechin gallate are determined for cancerous CAL27 and HSG cells, immortalized epithelioid S-G cells, and normal HGF-1 gingival fibroblasts. The concentration at which toxicity (P≤0.01) initially occur is 25 μM (-)-Catechin gallate for S-G cells, 50 μM (-)-Catechin gallate for CAL27 cells, 62.5 μM (-)-Catechin gallate for HSG cells and 75 μM (-)-Catechin gallate for HGF-1 fibroblasts. The calculated neutral red (NR50) values for a 3-day exposure to (-)-Catechin gallate are 58 μM for S-G cells, 62 μM for CAL27 cells, 90 μM for HSG cells and 132 μM for HGF-1 fibroblasts[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Cell Assay
[1]

Human tongue squamous carcinoma (CAL27) cells and human salivary gland carcinoma (HSG) cells are used. Individual wells of a 96-well microtiter tissue culture plate are inoculated with 0.2 mL of the growth medium containing 2×104 cells/well for a 1-day exposure, 1.5×104 cells/ well for a 2-day exposure and 1×104 cells/well for a 3-day exposure to the test agents. After 1 day of incubation, the growth medium is removed and replaced with exposure medium, with or without varied concentrations of the test agents. In some studies the cells are coexposed to (-)-Catechin gallate (100, 200, 300, 400, and 500 μM) and 100 Units/mL catalase. After 1-3 days of exposure to the test agents, viability is assessed with the neutral red (NR) assay, which is based on the uptake and accumulation of the supravital dye, neutral red (NR)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

442.37

Formula

C₂₂H₁₈O₁₀

CAS No.

130405-40-2

SMILES

O=C(O[[email protected]]1[[email protected]](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1)C4=CC(O)=C(O)C(O)=C4

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
(-)-Catechin gallate
Cat. No.:
HY-N0356
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(-)-Catechin gallate

Cat. No.: HY-N0356