1. Signaling Pathways
  2. Immunology/Inflammation
  3. COX
  4. COX-2 Inhibitors

COX-2 Inhibitors

COX

COX-1

COX-2

COX-3

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Sorry. There is currently no product that acts on isoform COX-2 together.

Please try each isoform separately.

COX-2 Specific Inhibitors
Product Name COX-2 COX-1 COX-2 Selectivity Purity
Celecoxib
COX-2, IC50: 40 nM
COX-1, IC50: 15 μM
Selective Inhibitor 99.50%
Imrecoxib
Human COX-2, IC50: 18 nM
Human COX-1, IC50: 115 nM
Selective Inhibitor >99.0%
Paradol
COX-2
  Selective Inhibitor 98.84%
NS-398
COX-2, IC50: 3.8 μM
  Selective Inhibitor 99.86%
Rofecoxib
Human COX-2, IC50: 18 nM (in Chinese hamster ovary cells)
Human COX-2, IC50: 26 nM (in human osteosarcoma cells)
  Selective Inhibitor 99.95%
Meloxicam
COX-2, IC50: 0.49 μM
COX-1, IC50: 36.6 μM
Selective Inhibitor 98.07%
Salicylic acid
COX-2
  Selective Inhibitor >98.0%
Sodium Salicylate
COX-2
  Selective Inhibitor 99.93%
Gallic acid
COX-2
  Selective Inhibitor 99.97%
Parecoxib Sodium
COX-2
  Selective Inhibitor 99.99%
Nabumetone
COX-2
  Selective Inhibitor 99.86%
Rutaecarpine
COX-2, IC50: 0.28 μM (in BMMC)
COX-1, IC50: 8.7 μM (in BMMC)
Selective Inhibitor 99.11%
Nimesulide
COX-2, IC50: 0.07-70 μM
  Selective Inhibitor 99.91%
Isoorientin
COX-2, IC50: 39 μM
  Selective Inhibitor 99.24%
Prim-O-glucosylcimifugin
COX-2
  Selective Inhibitor 99.76%
Valdecoxib
COX-2, IC50: 5 nM
COX-1, IC50: 140 μM
Selective Inhibitor 99.91%
Fenofibric acid
COX-2, IC50: 48 μM
  Selective Inhibitor 99.38%
Tolfenamic Acid
COX-2, IC50: 13.49 μM (in cell)
  Selective Inhibitor 99.93%
Etoricoxib
COX-2, IC50: 1.1 μM (in human whole blood)
COX-1, IC50: 116 μM (in human whole blood)
Selective Inhibitor 99.92%
Adelmidrol
COX-2
  Selective Inhibitor >98.0%
S-(+)-Marmesin
COX-2
  Selective Inhibitor 99.04%
Triflusal
COX-2, IC50: 280 μM
COX-2, IC50: 160 μM (in human blood)
  Selective Inhibitor 99.66%
Guaiacol
COX-2
  Selective Inhibitor 99.29%
Iguratimod
COX-2, IC50: 20 μM
  Selective Inhibitor 99.85%
Firocoxib
COX-2, IC50: 0.13 μM
COX-1, IC50: 7.5 μM
Selective Inhibitor 99.50%
Syringaldehyde
COX-2, IC50: 19.2 μM
  Selective Inhibitor 99.96%
Etodolac
COX-2, IC50: 41 nM (in CHO cells)
COX-1, IC50: ∼50000 nM (in CHO cells)
Selective Inhibitor 99.10%
Deracoxib
COX-2
  Selective Inhibitor 99.82%
SC57666
COX-2, IC50: 26 nM
  Selective Inhibitor
FR-188582
COX-2, IC50: 17 nM
  Selective Inhibitor 99.21%
Parecoxib
COX-2
  Selective Inhibitor 99.32%
Ginsenoside Rb3
COX-2
  Selective Inhibitor >99.0%
Inulicin
COX-2
  Selective Inhibitor 99.38%
FK 3311
COX-2
  Selective Inhibitor 98.06%
Amfenac Sodium Hydrate
COX-2
  Selective Inhibitor 98.65%
Tenidap
COX-2, IC50: 1.2 μM
COX-1, IC50: 0.03 μM
Selective Inhibitor
[10]-Shogaol
COX-2, IC50: 7.5 μM
  Selective Inhibitor
α-Humulene
COX-2
  Selective Inhibitor
GW-406381
COX-2
  Selective Inhibitor 99.59%
α-Spinasterol
COX-2, IC50: 7.76 μM
COX-1, IC50: 16.17 μM
Selective Inhibitor
[8]-Shogaol
COX-2, IC50: 17.5 μM
  Selective Inhibitor
RWJ 63556
COX-2
  Selective Inhibitor
Flosulide
COX-2
  Selective Inhibitor
Thioflosulide
COX-2, IC50: 2.3 nM
  Selective Inhibitor
S-2474
COX-2, IC50: 11 nM
COX-1, IC50: 27 μM
Selective Inhibitor
Tilmacoxib
Human COX-2, IC50: 85 nM
  Selective Inhibitor
SC58451
COX-2
  Selective Inhibitor
COX-2-IN-1
COX-2, IC50: 3.9 μM
  Selective Inhibitor
COX-2-IN-2
COX-2, IC50: 240 nM
  Selective Inhibitor
Acetaminophen
COX-2, IC50: 25.8 μM
COX-1, IC50: 113.7 μM
Pan Inhibitor 99.69%
Indomethacin
Human COX-2, IC50: 26 nM (in CHO cells)
Human COX-1, IC50: 18 nM (in CHO cells)
Pan Inhibitor >98.0%
Aspirin
COX-2, IC50: 1.17 mM
COX-1, IC50: 27.75 μM
Pan Inhibitor >99.0%
Ibuprofen
COX-2, IC50: 370 μM
COX-1, IC50: 13 μM
Pan Inhibitor 99.99%
Diclofenac
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Pan Inhibitor 99.98%
Carprofen
COX-2, IC50: 3.9 μM
COX-1, IC50: 22.3 μM
Pan Inhibitor 99.76%
SC-560
COX-2, IC50: 6.3 μM
COX-1, IC50: 9 nM
Pan Inhibitor 99.58%
Ketoprofen
COX-2, IC50: 26 nM (in human blood monocytes)
COX-1, IC50: 2 nM (in human blood monocytes)
Pan Inhibitor 99.80%
Sulindac
COX-2
  Pan Inhibitor 99.46%
Naproxen
COX-2, IC50: 5.65 μM
COX-1, IC50: 9.55 μM
Pan Inhibitor 99.66%
Piroxicam
COX-2, IC50: 25 μM (in human monocytes)
COX-1, IC50: 47 μM (in human monocytes)
Pan Inhibitor 99.73%
Diclofenac Sodium
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Pan Inhibitor >98.0%
Ketorolac tromethamine salt
COX-2, IC50: 120 nM
COX-1, IC50: 20 nM
Pan Inhibitor 99.94%
S-(+)-Ketoprofen
COX-2, IC50: 370 μM
COX-1, IC50: 13 μM
Pan Inhibitor 99.95%
Oxaprozin
COX-2, IC50: 36 μM
COX-1, IC50: 2.2 μM
Pan Inhibitor 99.63%
Naproxen sodium
COX-2, IC50: 5.65 μM (in intact cells )
COX-1, IC50: 9.55 μM (in intact cells )
Pan Inhibitor 99.98%
Aceclofenac
COX-2, IC50: 3 μM
COX-1, IC50: 7.3 μM
Pan Inhibitor 99.80%
Mefenamic acid
hCOX-2, IC50: 3 μM
hCOX-1, IC50: 40 nM
Pan Inhibitor 99.99%
Tenoxicam
COX-2
COX-1
Pan Inhibitor 99.83%
Jaceosidin
COX-2
  Pan Inhibitor 99.99%
(-)-Catechin gallate
COX-2
COX-1
Pan Inhibitor 99.98%
Phenylbutazone
COX-2, IC50: 1.1 μM
COX-1, IC50: 3.7 μM
Pan Inhibitor 98.86%
Loxoprofen
COX-2, IC50: 13.5 μM (in human whole blood)
COX-1, IC50: 6.5 μM (in human whole blood)
Pan Inhibitor 98.82%
Lornoxicam
COX-2, IC50: 45 nM (in cells)
COX-1, IC50: 5 nM (in cells)
Pan Inhibitor 98.31%
Flunixin meglumine
COX-2, IC50: 0.4 nM
COX-1, IC50: 17 nM
Pan Inhibitor 99.65%
Asaraldehyde
COX-2
  Pan Inhibitor 99.68%
Diclofenac diethylamine
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Pan Inhibitor 99.93%
Roburic acid
COX-2, IC50: 9 μM
COX-1, IC50: 5 μM
Pan Inhibitor
(E)-Ethyl p-methoxycinnamate
COX-2, IC50: 0.83 μM
COX-1, IC50: 1.12 μM
Pan Inhibitor
Anemarsaponin B
COX-2
  Pan Inhibitor
Cafestol
COX-2
  Pan Inhibitor
N-trans-Feruloyltyramine
COX-2
COX-1
Pan Inhibitor
Byakangelicol
COX-2
  Pan Inhibitor
Ethyl Caffeate
COX-2
  Pan Inhibitor
Zaltoprofen
COX-2, IC50: 111 μM
COX-1, IC50: 149 μM
Pan Inhibitor 99.09%
Ketorolac
COX-2, IC50: 120 nM
COX-1, IC50: 20 nM
Pan Inhibitor