1. Signaling Pathways
  2. Immunology/Inflammation
  3. COX
  4. COX-2 Inhibitors

COX-2 Inhibitors

COX

COX-1

COX-2

COX-3

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Sorry. There is currently no product that acts on isoform COX-2 together.

Please try each isoform separately.

COX-2 Specific Inhibitors, Activators & Modulators
Product Name COX-2 COX COX-1 COX-2 Selectivity Purity
Celecoxib
COX-2, IC50: 40 nM
 
COX-1, IC50: 15 μM
Selective Inhibitor 99.59%
Lumiracoxib
COX-2, Ki: 0.06 μM
 
COX-1, Ki: 3 μM
Selective Inhibitor ≥98.0%
NS-398
COX-2, IC50: 3.8 μM
    Selective Inhibitor 98.70%
20(S)-Ginsenoside Rg3
COX-2
    Selective Inhibitor ≥98.0%
Gallic acid
COX-2
    Selective Inhibitor 99.85%
Salicylic acid
COX-2
    Selective Inhibitor ≥98.0%
Rutaecarpine
COX-2, IC50: 0.28 μM (in BMMC)
 
COX-1, IC50: 8.7 μM (in BMMC)
Selective Inhibitor 98.11%
Meloxicam
COX-2, IC50: 0.49 μM
 
COX-1, IC50: 36.6 μM
Selective Inhibitor 99.88%
Rebamipide
COX-2
    Selective Activator 99.88%
Iguratimod
COX-2, IC50: 20 μM
    Selective Inhibitor 99.97%
Isoorientin
COX-2, IC50: 39 μM
    Selective Inhibitor 99.26%
Rofecoxib
Human COX-2, IC50: 18 nM (in Chinese hamster ovary cells)
Human COX-2, IC50: 26 nM (in human osteosarcoma cells)
    Selective Inhibitor 99.91%
Fenofibric acid
COX-2, IC50: 48 μM
    Selective Inhibitor ≥98.0%
Sodium Salicylate
COX-2
    Selective Inhibitor ≥99.0%
Nabumetone
COX-2
    Selective Inhibitor 99.98%
Isofraxidin
COX-2
    Selective Inhibitor 98.14%
Nimesulide
COX-2, IC50: 0.07-70 μM
    Selective Inhibitor 99.70%
Ginsenoside Rd
COX-2
    Selective Inhibitor ≥98.0%
Ginsenoside C-K
COX-2
    Selective Inhibitor ≥98.0%
Etoricoxib
COX-2, IC50: 1.1 μM (in human whole blood)
 
COX-1, IC50: 116 μM (in human whole blood)
Selective Inhibitor 99.10%
Ginsenoside Rb3
COX-2
    Selective Inhibitor ≥99.0%
Ginsenoside Rg5
COX-2
    Selective Inhibitor ≥99.0%
Psoralidin
COX-2
    Selective Inhibitor ≥99.0%
Imrecoxib
Human COX-2, IC50: 18 nM
 
Human COX-1, IC50: 115 nM
Selective Inhibitor ≥99.0%
Paradol
COX-2
    Selective Inhibitor 99.88%
Guaiacol
COX-2
    Selective Inhibitor ≥97.0%
Tolfenamic Acid
COX-2, IC50: 13.49 μM (in cell)
    Selective Inhibitor ≥98.0%
SC-236
COX-2, IC50: 10 nM
 
COX-1, IC50: 17.8 μM
Selective Inhibitor 99.24%
Pectolinarigenin
COX-2
    Selective Inhibitor 99.47%
[8]-Shogaol
COX-2, IC50: 17.5 μM
    Selective Inhibitor 99.74%
Parecoxib
COX-2
    Selective Inhibitor 98.34%
Etodolac
COX-2, IC50: 41 nM (in CHO cells)
 
COX-1, IC50: ∼50000 nM (in CHO cells)
Selective Inhibitor 99.11%
Adelmidrol
COX-2
    Selective Inhibitor ≥98.0%
S-(+)-Marmesin
COX-2
    Selective Inhibitor 99.11%
Macelignan
COX-2
    Selective Inhibitor ≥98.0%
Prim-O-glucosylcimifugin
COX-2
    Selective Inhibitor ≥98.0%
Deracoxib
COX-2
    Selective Inhibitor 99.77%
Valdecoxib
COX-2, IC50: 5 nM
 
COX-1, IC50: 140 μM
Selective Inhibitor 99.96%
N-tert-Butyl-α-phenylnitrone
COX-2
    Selective Inhibitor ≥98.0%
Syringaldehyde
COX-2, IC50: 19.2 μM
    Selective Inhibitor ≥98.0%
Hexahydrocurcumin
COX-2
    Selective Inhibitor 99.70%
Triflusal
COX-2, IC50: 280 μM
COX-2, IC50: 160 μM (in human blood)
    Selective Inhibitor 99.64%
FK 3311
COX-2
    Selective Inhibitor 98.38%
Columbin
COX-2, EC50: 53.1 μM
 
COX-1, EC50: 327 μM
Selective Inhibitor 98.86%
Firocoxib
COX-2, IC50: 0.13 μM
 
COX-1, IC50: 7.5 μM
Selective Inhibitor 98.42%
2,5-Di-tert-butylhydroquinone
COX-2, IC50: 14.1 μM
    Selective Modulator ≥98.0%
Amfenac Sodium Hydrate
COX-2
    Selective Inhibitor 98.65%
Mavacoxib
COX-2
    Selective Inhibitor 99.83%
Tenidap
COX-2, IC50: 1.2 μM
 
COX-1, IC50: 0.03 μM
Selective Inhibitor ≥99.0%
CAY10404
COX-2, IC50: 1 nM
 
COX-1, IC50: >500 μM
Selective Inhibitor ≥99.0%
GW-406381
COX-2
    Selective Inhibitor ≥99.0%
Parecoxib Sodium
COX-2
    Selective Inhibitor 99.99%
Alminoprofen
COX-2
    Selective Inhibitor 99.35%
[10]-Shogaol
COX-2, IC50: 7.5 μM
    Selective Inhibitor 99.78%
α-Spinasterol
COX-2, IC50: 7.76 μM
 
COX-1, IC50: 16.17 μM
Selective Inhibitor 99.15%
SC57666
COX-2, IC50: 26 nM
    Selective Inhibitor 98.94%
FR-188582
COX-2, IC50: 17 nM
    Selective Inhibitor 99.21%
Inulicin
COX-2
    Selective Inhibitor 99.42%
DuP-697
hCOX-2, IC50: 10 nM
 
hCOX-1, IC50: 800 nM
Selective Inhibitor
Desmethyl Celecoxib
COX-2, IC50: 32 nM
    Selective Inhibitor 99.09%
α-​Chaconine
COX-2
    Selective Inhibitor
Ermanin
COX-2
    Selective Inhibitor
α-Humulene
COX-2
    Selective Inhibitor
Sphondin
COX-2
    Selective Inhibitor
Mefenamic acid D4
hCOX-2, IC50: 3 nM
 
hCOX-1, IC50: 40 nM
Selective Inhibitor
SC-58125
hCOX-2, IC50: 0.04 μM
 
hCOX-1, IC50: >100 μM
Selective Inhibitor
Salicylic acid-D6
COX-2
    Selective Inhibitor
Nimesulide D5
COX-2, IC50: 0.07-70 μM
    Selective Inhibitor
RWJ 63556
COX-2
    Selective Inhibitor
Flosulide
COX-2
    Selective Inhibitor
Thioflosulide
COX-2, IC50: 2.3 nM
    Selective Inhibitor
S-2474
COX-2, IC50: 11 nM
 
COX-1, IC50: 27 μM
Selective Inhibitor
Tilmacoxib
Human COX-2, IC50: 85 nM
    Selective Inhibitor ≥99.0%
SC58451
COX-2
    Selective Inhibitor
COX-2-IN-1
COX-2, IC50: 3.9 μM
    Selective Inhibitor
COX-2-IN-2
COX-2, IC50: 240 nM
    Selective Inhibitor
Acetaminophen
COX-2, IC50: 25.8 μM
 
COX-1, IC50: 113.7 μM
Pan Inhibitor 99.96%
Indomethacin
Human COX-2, IC50: 26 nM (in CHO cells)
 
Human COX-1, IC50: 18 nM (in CHO cells)
Pan Inhibitor 99.97%
Aspirin
COX-2, IC50: 1.17 mM
 
COX-1, IC50: 27.75 μM
Pan Inhibitor ≥99.0%
Ibuprofen
COX-2, IC50: 370 μM
 
COX-1, IC50: 13 μM
Pan Inhibitor 99.97%
Mofezolac
COX-2, IC50: 447 nM
 
COX-1, IC50: 1.44 nM
Pan Inhibitor 98.83%
Diclofenac
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Pan Inhibitor 99.97%
Diclofenac Sodium
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Pan Inhibitor 99.93%
Naproxen
COX-2, IC50: 5.65 μM
 
COX-1, IC50: 9.55 μM
Pan Inhibitor ≥98.0%
Sulindac
COX-2
    Pan Inhibitor 99.81%
Carprofen
COX-2, IC50: 3.9 μM
 
COX-1, IC50: 22.3 μM
Pan Inhibitor 99.96%
SC-560
COX-2, IC50: 6.3 μM
 
COX-1, IC50: 9 nM
Pan Inhibitor 99.77%
Piroxicam
COX-2, IC50: 25 μM (in human monocytes)
 
COX-1, IC50: 47 μM (in human monocytes)
Pan Inhibitor 99.61%
Flurbiprofen
COX-2
COX
COX-1
Pan Inhibitor 99.92%
Neochlorogenic acid
COX-2
    Pan Inhibitor 99.07%
Ketoprofen
COX-2, IC50: 26 nM (in human blood monocytes)
 
COX-1, IC50: 2 nM (in human blood monocytes)
Pan Inhibitor 99.93%
ATB-346
COX-2
 
COX-1
Pan Inhibitor 98.35%
Ketorolac tromethamine salt
COX-2, IC50: 120 nM
 
COX-1, IC50: 20 nM
Pan Inhibitor 99.94%
Fenbufen
COX-2, IC50: 8.1 μM
 
COX-1, IC50: 3.9 μM
Pan Inhibitor 98.99%
Bromfenac sodium hydrate
COX-2, IC50: 7.45 nM
 
COX-1, IC50: 5.56 nM
Pan Inhibitor 99.91%
Madecassic acid
COX-2
    Pan Inhibitor 98.34%
Mefenamic acid
hCOX-2, IC50: 3 μM
 
hCOX-1, IC50: 40 nM
Pan Inhibitor 99.97%
(S)-Flurbiprofen
COX-2, IC50: 0.47 μM
 
COX-1, IC50: 0.48 μM
Pan Inhibitor 99.83%
(-)-Catechin gallate
COX-2
 
COX-1
Pan Inhibitor 99.98%
Diclofenac diethylamine
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Pan Inhibitor 99.93%
S-(+)-Ketoprofen
COX-2, IC50: 370 μM
 
COX-1, IC50: 13 μM
Pan Inhibitor 99.93%
Jaceosidin
COX-2
    Pan Inhibitor 99.99%
Oxaprozin
COX-2, IC50: 36 μM
 
COX-1, IC50: 2.2 μM
Pan Inhibitor 99.76%
Pranoprofen
COX-2
 
COX-1
Pan Inhibitor 99.37%
Naproxen sodium
COX-2, IC50: 5.65 μM (in intact cells )
 
COX-1, IC50: 9.55 μM (in intact cells )
Pan Inhibitor ≥98.0%
Tenoxicam
COX-2
 
COX-1
Pan Inhibitor 99.94%
Harpagoside
COX-2
 
COX-1
Pan Inhibitor 98.35%
Byakangelicol
COX-2
    Pan Inhibitor 99.51%
Lornoxicam
COX-2, IC50: 45 nM (in cells)
 
COX-1, IC50: 5 nM (in cells)
Pan Inhibitor 98.31%
β-Elemonic acid
COX-2
    Pan Activator ≥99.0%
Tolmetin
Human COX-2, IC50: 0.82 μM
 
Human COX-1, IC50: 0.35 μM
Pan Inhibitor ≥98.0%
Ethyl Caffeate
COX-2
    Pan Inhibitor 98.91%
Asaraldehyde
COX-2
    Pan Inhibitor ≥98.0%
Zaltoprofen
COX-2, IC50: 0.34 μM
 
COX-1, IC50: 1.3 μM
Pan Inhibitor ≥98.0%
(S)-(+)-Ibuprofen
COX-2, IC50: 1.6 μM
 
COX-1, IC50: 2.1 μM
Pan Inhibitor 99.98%
Flunixin meglumine
COX-2, IC50: 0.4 nM
 
COX-1, IC50: 17 nM
Pan Inhibitor 99.65%
Bromfenac sodium
COX-2, IC50: 7.45 nM
 
COX-1, IC50: 5.56 nM
Pan Inhibitor
Gallic acid hydrate
COX-2
    Pan Inhibitor ≥98.0%
Aceclofenac
COX-2, IC50: 3 μM
 
COX-1, IC50: 7.3 μM
Pan Inhibitor 99.75%
Ketorolac D5
COX-2, IC50: 120 nM
 
COX-1, IC50: 20 nM
Pan Inhibitor ≥98.0%
(E)-Ethyl p-methoxycinnamate
COX-2, IC50: 0.83 μM
 
COX-1, IC50: 1.12 μM
Pan Inhibitor 99.39%
Isoxicam
COX-2
 
COX-1
Pan Inhibitor 99.11%
Cafestol
COX-2
    Pan Inhibitor 99.91%
N-trans-Feruloyltyramine
COX-2
 
COX-1
Pan Inhibitor 98.64%
Loxoprofen
COX-2, IC50: 13.5 μM (in human whole blood)
 
COX-1, IC50: 6.5 μM (in human whole blood)
Pan Inhibitor 99.76%
Tolmetin sodium dihydrate
Human COX-2, IC50: 0.82 μM
 
Human COX-1, IC50: 0.35 μM
Pan Inhibitor 99.77%
Diclofenac potassium
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 nM
 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 nM
Pan Inhibitor ≥98.0%
Loxoprofen sodium
COX-2, IC50: 13.5 μM
 
COX-1, IC50: 6.5 μM
Pan Inhibitor ≥98.0%
7,3',4'-Tri-O-methylluteolin
COX-2
    Pan Inhibitor
AG-024322
COX-2, Ki: 3 nM
 
COX-1, Ki: 2.3 nM
Pan Inhibitor
Roburic acid
COX-2, IC50: 9 μM
 
COX-1, IC50: 5 μM
Pan Inhibitor
Humulone
COX-2
    Pan Inhibitor
Indomethacin-D4
Human COX-2, IC50: 26 nM (in CHO cells)
 
Human COX-1, IC50: 18 nM (in CHO cells)
Pan Inhibitor
(S)-(+)-Ibuprofen D3
COX-2, IC50: 1.6 μM
 
COX-1, IC50: 2.1 μM
Pan Inhibitor
Taraxerol acetate
COX-2, IC50: 94.7 μM
 
COX-1, IC50: 116.3 μM
Pan Inhibitor
Plantanone B
Ovine COX-2, IC50: 44.01±0.42 μM
 
Ovine COX-1, IC50: 21.78±0.2 μM
Pan Inhibitor
Floctafenine
COX-2
 
COX-1
Pan Inhibitor
Anemarsaponin B
COX-2
    Pan Inhibitor
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone
COX-2
 
COX-1
Pan Inhibitor
Pelubiprofen
COX-2
    Pan Inhibitor
Hamaudol
COX-2, IC50: 0.57 mM
 
COX-1, IC50: 0.3 mM
Pan Inhibitor
Ketorolac
COX-2, IC50: 120 nM
 
COX-1, IC50: 20 nM
Pan Inhibitor
Xanthohumol
COX-2
 
COX-1
Inhibitor 99.84%
Peonidin chloride
COX-2
    Inhibitor