Cat. No.: HY-B1773A

Sodium propionate

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease.

For research use only. We do not sell to patients.

Purity: 99.0%
CAS No.: 137-40-6
Formula: C₃H₅NaO₂
Molecular Weight:96.06

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Sodium propionate Chemical Structure

CAS No.: 137-40-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Publications Citing Use of MedChemExpress (MCE) Sodium propionate

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In Vivo Efficacy StudyWBCell Imaging/StainingIHC

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Cell Imaging/Staining
IHC
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In Vivo Efficacy Study

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]^[2]^[3]^[4]^[5]^[6]

PPAR-γ

HSV-1

COX-2

All PPAR Isoforms :

All NO Synthase Isoforms :

All Endogenous Metabolite Isoforms :

All HSV Isoforms :

All COX Isoforms :

All NF-κB Isoforms :

In Vitro

Sodium propionate (10-100 mM; 24 h for viability test) inhibits viability of GBM cell lines (U-87, A-172, U-138) in a concentration-dependent manner, induces apoptosis and autophagy in U-87 cells^[1].
Sodium propionate (1-10 μM) shows potential anti-oxidant effect in J774-A1 cell cultures stimulated with hydrogen peroxide^[2].
Sodium propionate (0.1 μM-10 mM) protects SH-SY5Y neuroblastoma cells from Aβ_1-42-induced neurotoxicity by inhibiting NF-κB activation, reducing iNOS/COX-2 expression and NO production^[3].
Sodium propionate (100 μM-3.2 mM) inhibits differentiation of naive splenocytes into Th1/Th17 cells and promotes Treg differentiation^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

U-87
Concentration:

50 mM, 100 mM
Incubation Time:
Result:

Induced apoptosis.
Upregulated p53, Bax, and caspase-3 protein levels.
Downregulated Bcl-2 protein level.

Cell Autophagy Assay^[1]

Cell Line:

U-87
Concentration:

50 mM, 100 mM
Incubation Time:
Result:

Activated autophagy.
Upregulated LC3II/I, Beclin-1, and Atg5 protein levels.
Downregulated p62 protein level.

In Vivo

Sodium propionate (30-100 mg/kg; p.o.; 2 weeks) reduces tumor growth, improves pathological features, and inhibits proliferation in BALB/c nude mice bearing U-87 GBM xenografts^[1].
Sodium propionate (10-100 mg/kg; p.o.; 30 min before CAR subplantar injection) reduces Carrageenan (HY-125474)-induced paw edema and KO₂-induced pain/inflammation in Sprague-Dawley rats by inhibiting iNOS/COX-2 and enhancing antioxidant enzymes^[2].
Sodium propionate (10-100 mg/kg; p.o.; 1 h and 6 h after injury) alleviates spinal cord trauma (SCI) in CD1 mice by reducing neuroinflammation, lipid peroxidation, and improving motor function ^[3].
Sodium propionate (500 mM; p.o. via drinking water; 3 weeks before infection to experiment end) reduces HSV-1-induced ocular stromal keratitis (SK) in C57BL/6 mice by regulating T cell balance (increasing Treg/Th1/Th17 ratio) and reducing inflammation^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude male mice (25-30 g; 6-8 weeks old) bearing U-87 GBM xenografts^[1]
Dosage:

10 mg/kg, 30 mg/kg, 100 mg/kg
Administration:

oral gavage, 2 weeks
Result:

Decreased tumor necrosis and neutrophil infiltration.
Reduced Ki-67 (proliferation marker) expression.
Induced apoptosis and autophagy.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 137-40-6
Appearance Solid
Molecular Weight 96.06
Formula C₃H₅NaO₂
Color White to off-white
SMILES

O=C(CC)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (2)

All In Vivo Efficacy StudyWBCell Imaging/StainingIHC

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Life Metab

2025 Oct 8.

Sodium propionate purchased from MedChemExpress. Usage Cited in: Life Metab. 2025 Oct 8.

Sodium propionate (2-8 nM; 24 h). Fibrosis-related markers such as TIMP-1, α-SMA, and Col1α1 and TGF-β1 protein expression assayed by western blotting.

Sodium propionate purchased from MedChemExpress. Usage Cited in: Life Metab. 2025 Oct 8.

Sodium propionate (2-8 nM; 24 h). ROS visualized by microscopy using the 2’,7’-dichlorodihydrofluorescein diacetate (DCFH-DA) probe at a final concentration of 10 μmol/L.

Sodium propionate purchased from MedChemExpress. Usage Cited in: Life Metab. 2025 Oct 8.

Sodium propionate (400 mM; drinking water). Representative images of H&E, Masson, and Sirius Red staining (Scale bar = 25 μm) in the liver.

Sodium propionate purchased from MedChemExpress. Usage Cited in: Life Metab. 2025 Oct 8.

Sodium propionate (400 mM; drinking water). Oxidative stress-related Keap1/Nrf2 pathway protein expression assayed by western blotting.
iScience

Biglycan regulated colorectal cancer progress by modulating enteric neuron-derived IL-10 and abundance of Bacteroides thetaiotaomicron. [Abstract]

2023 Aug 2;26(9):107515. PMID: 37664615

Sodium propionate purchased from MedChemExpress. Usage Cited in: iScience. 2023 Aug 2;26(9):107515. [Abstract]

Sodium propionate (SP; 100 mM; 100 μL; intratumoral injection). Sodium propionate reduced the growth of MC38 allograft tumors.

Solvent & Solubility

In Vitro:

H₂O : ≥ 200 mg/mL (2082.03 mM)

DMSO : 2 mg/mL (20.82 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

10.4102 mL

52.0508 mL

104.1016 mL

5 mM

2.0820 mL

10.4102 mL

20.8203 mL

10 mM

1.0410 mL

5.2051 mL

10.4102 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Filippone A, et al. Sodium Propionate Contributes to Tumor Cell Growth Inhibition through PPAR-γ Signaling. Cancers (Basel). 2022 Dec 29;15(1):217. [Content Brief]

[2]. Filippone A, et al. The anti-inflammatory and antioxidant effects of sodium propionate. International journal of molecular sciences, 2020, 21(8): 3026.

[3]. Filippone A, et al. Protective effect of sodium propionate in Aβ1-42-induced neurotoxicity and spinal cord trauma. Neuropharmacology. 2020 Apr;166:107977. [Content Brief]

[4]. Park HS, et al. Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling. Acta Pharmacol Sin. 2021 Aug;42(8):1311-1323. [Content Brief]

[5]. Sumbria D, et al. Supplementing the Diet with Sodium Propionate Suppresses the Severity of Viral Immuno-inflammatory Lesions. J Virol. 2021 Jan 28;95(4):e02056-20. [Content Brief]

[6]. Lang W, et al. Sodium propionate improves cognitive and memory function in mouse models of Alzheimer's disease. Neurosci Lett. 2022 Nov 20;791:136887. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	10.4102 mL	52.0508 mL	104.1016 mL	260.2540 mL
	5 mM	2.0820 mL	10.4102 mL	20.8203 mL	52.0508 mL
	10 mM	1.0410 mL	5.2051 mL	10.4102 mL	26.0254 mL
	15 mM	0.6940 mL	3.4701 mL	6.9401 mL	17.3503 mL
	20 mM	0.5205 mL	2.6025 mL	5.2051 mL	13.0127 mL
H₂O	25 mM	0.4164 mL	2.0820 mL	4.1641 mL	10.4102 mL
	30 mM	0.3470 mL	1.7350 mL	3.4701 mL	8.6751 mL
	40 mM	0.2603 mL	1.3013 mL	2.6025 mL	6.5064 mL
	50 mM	0.2082 mL	1.0410 mL	2.0820 mL	5.2051 mL
	60 mM	0.1735 mL	0.8675 mL	1.7350 mL	4.3376 mL
	80 mM	0.1301 mL	0.6506 mL	1.3013 mL	3.2532 mL
	100 mM	0.1041 mL	0.5205 mL	1.0410 mL	2.6025 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Sodium propionate

2 Cited Publications

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Sodium propionate

Anti-Infection Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Antiviral Compound Library

Autophagy Compound Library

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Differentiation Inducing Compound Library

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Antibacterial Compound Library

Ferroptosis Compound Library

Pyroptosis Compound Library

Orally Active Compound Library

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Publications Citing Use of MedChemExpress (MCE) Sodium propionate

All PPAR Isoforms

All NO Synthase Isoforms

All Endogenous Metabolite Isoforms

All HSV Isoforms

All COX Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References