1. Signaling Pathways
  2. Immunology/Inflammation
  3. NO Synthase
  4. iNOS Isoform


iNOS, also known as NOS-2, is a 131 kDa mammalian protein composed of 1,153 amino acids, which are assembled into two major domains, a C-terminal reductase—containing a flavin mononucleotide (FMN) binding subdomain—and a N-terminal oxygenase.iNOS adopts a zinc-bridged, homodimeric quaternary structure that allows the enzyme to convert L-Arg to L-citrulline with the concomitant production of NO. This transformation is governed by an elaborate electron transport chain, involving the cofactors nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN), heme, and (6R)-5,6,7,8-tetrahydrobiopterin (H4B), which are essential for this reaction. This process is mediated by CaM, which binds in a hinge region between the oxygenase and reductase domains.

iNOS Related Products (24):

Cat. No. Product Name Effect Purity