2. NF-κB Immunology/Inflammation
  3. NF-κB Interleukin Related COX NO Synthase
  4. Anti-inflammatory agent 109

Anti-inflammatory agent 109 (Compound 2m) is an anti-inflammatory agent. Anti-inflammatory agent 109 directly interacts with p65, attenuates aberrant activation of the NF-κB pathway. Anti-inflammatory agent 109 significantly suppresses the release of key pro-inflammatory mediators, including IL-1β, COX-2, and iNOS. Anti-inflammatory agent 109 conferres robust protection against LPS-induced acute liver injury in septic mice.

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Anti-inflammatory agent 109

Anti-inflammatory agent 109 Chemical Structure

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Anti-inflammatory agent 109 Related Antibodies

Top Publications Citing Use of Products

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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COX COX-1 COX-2 COX-3

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nNOS iNOS eNOS

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Description

Anti-inflammatory agent 109 (Compound 2m) is an anti-inflammatory agent. Anti-inflammatory agent 109 directly interacts with p65, attenuates aberrant activation of the NF-κB pathway. Anti-inflammatory agent 109 significantly suppresses the release of key pro-inflammatory mediators, including IL-1β, COX-2, and iNOS. Anti-inflammatory agent 109 conferres robust protection against LPS-induced acute liver injury in septic mice[1].

IC50 & Target[1]

COX-2

 

IL-1β

 

iNOS

 

Molecular Weight

640.89

Formula

C39H60O7
SMILES

CC(C)(O)[C@H]1CC[C@]([C@]2([H])[C@]([C@H](O)C[C@@]3([H])[C@@]4(C)CC[C@]5([H])[C@]3(C)CC[C@H](OC(COC6=C(OC)C=CC=C6)=O)C5(C)C)([H])[C@@]4(C)CC2)(C)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 109 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 109NF-κBInterleukin RelatedCOXNO SynthaseNuclear factor-κBNuclear factor-kappaBILCyclooxygenaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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Anti-inflammatory agent 109
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